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Many elite female athletes struggle to maintain performance while transitioning from high school to university-level (senior) sports. This study explores factors of body composition that influenced performance in elite junior female track and field athletes transitioning to the senior division. Forty-two elite female track and field athletes, ranked among the top 100 in Japan, were enrolled in this study. Whole-body mode dual-energy X-ray absorptiometry scans were performed during the post-season of 2016 and 2017. Athletes' performances were assessed using the International Association of Athletics Federation scoring system. Relationships between changes in performance and those in body composition were investigated. There were significant negative correlations between changes in performance and fat mass (FM), and percentage FM (FM%). BI3812 This was seen in total body and lower extremities, and not in the trunk and upper extremities. In addition, there was a positive correlation between changes in performance and percentage lean mass (LM%). However, there were no correlations between changes in performance and LM and total mass. Elite female track and field athletes transitioning to senior division should decrease their FM and FM% and increase LM%, to sustain or improve performance. It is also more important to monitor changes in body composition than body mass.Red clover consists of the overground parts and inflorescence of Trifolium pratense L., a leguminous plant belonging to the genus Trifolium. It is widely distributed worldwide and has long been used in traditional medicine. In this study, a combination approach using UPLC-MS and network pharmacology was applied to explore the quality control markers for the quality assessments of red clover. Firstly, UPLC-MS was used to identify the compounds in different parts of red clover. Twenty-eight compounds were totally identified. According to the traditional clinical efficacy of red clover, a compound-target-function network was constructed by network pharmacology to discover the main active compounds based on the identified compounds. Nine compounds of chlorogenic acid, daidzin, calycosin-7-O-β-d-glucoside, genistin, ononin, daidzein, genistein, formononetin, and biochanin A were filtrated and further confirmed in rat plasma in view of the blood-absorbed components taking effects. Finally, a novel method for simultaneously detecting the nine quality control markers was developed by UPLC-QQQ-MS in an effort to assess the quality of red clover. For all samples, the average contents of the nine compounds measured from high to low consist of formononetin, ononin, biochanin A, genistin, daidzin, calycosin-7-O-β-d-glucoside, genistein, daidzein, and chlorogenic acid. The samples from Gansu province showed the best quality in the three producing areas This study provides new strategies to explore the quality control markers and develops a novel method for the quality assessment of red clover.We assessed the effect of different doses of vitamin D supplementation on microcirculation, signs and symptoms of peripheral neuropathy and inflammatory markers in patients with type 2 diabetes (T2DM). Sixty-seven patients with T2DM and peripheral neuropathy (34 females) were randomized into two treatment groups Cholecalciferol 5000 IU and 40,000 IU once/week orally for 24 weeks. Severity of neuropathy (NSS, NDS scores, visual analogue scale), cutaneous microcirculation (MC) parameters and inflammatory markers (ILs, CRP, TNFα) were assessed before and after treatment. Vitamin D deficiency/insufficiency was detected in 78% of the 62 completed subjects. Following treatment with cholecalciferol 40,000 IU/week, a significant decrease in neuropathy severity (NSS, p = 0.001; NDS, p = 0.001; VAS, p = 0.001) and improvement of cutaneous MC were observed (p less then 0.05). Also, we found a decrease in IL-6 level (2.5 pg/mL vs. 0.6 pg/mL, p less then 0.001) and an increase in IL-10 level (2.5 pg/mL vs. 4.5 pg/mL, p less then 0.001) after 24 weeks of vitamin D supplementation in this group. No changes were detected in the cholecalciferol 5000 IU/week group. High-dose cholecalciferol supplementation of 40,000 IU/week for 24 weeks was associated with improvement in clinical manifestation, cutaneous microcirculation and inflammatory markers in patients with T2DM and peripheral neuropathy.Active vibration control is the most effective method for stochastic multidimensional vibration in wind tunnel tests, in which vibration monitoring is the core foundation. Vibrations are induced by the disturbances of several complex air flow instabilities under extreme test conditions with high attack angles. Here, a decoupled unified observation method is proposed in order to fully monitor stochastic multidimensional vibration. First, stochastic multidimensional vibration is explained using the Cartesian coordinate system. Then, the multidimensional vibration decoupling of the pitch plane and the yaw plane is realized according to the proposed decoupling design principle of the long cantilever sting. A unified observation method is presented, based on inertial force theory, to observe multidimensional vibration due to acceleration in each decoupling plane. Verification experiments were conducted in lab and a transonic wind tunnel, using an established real-time monitoring system. The results of lab experiments indicate that, in the frequency region of 0-120 Hz, three vibration modes of a selected stochastic vibration can be decoupled and observed through the vibration components in pitch plane and yaw plane. In addition, wind tunnel tests were carried out according to the working conditions (α = -4~10° with γ = 45°) at Ma = 0.6 and Ma = 0.7, respectively. The results show that six vibration modes of two selected stochastic vibrations can be decoupled and observed through the vibration components in pitch plane and yaw plane. The experimental results prove that stochastic vibration can be fully monitored in multiple dimensions through the vibration components in pitch plane and yaw plane using the proposed decoupled unified observation method. Therefore, these results lay the foundation for active vibration control.
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