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Fast Id regarding Potential Drug Individuals from Multi-Million Compounds' Repositories. Blend of 2nd Similarity Look for along with 3 dimensional Ligand/Structure Based Methods plus Vitro Testing.
A multidisciplinary approach to the treatment of adult rhabdomyosarcoma has been recommended. The combined use of chemoradiotherapy and surgery has improved treatment in the recent past but RMS in adults is still a rare head and neck tumour that carries a poor prognosis despite aggressive therapy.Introduction One of the most common complications following total laryngectomy is pharyngocutaneous fistula (PCF). Various methods have been proposed to treat this disorder in recent studies, including a range of simple and conservative treatments to more aggressive therapies, such as various surgical procedures. One of the most innovative and least developed methods is the use of plasma-rich compounds, such as fibrin glue. Case Report The patient was a 55-year-old woman with a transglottic squamous cell carcinoma of the T3N0M0 stage and PCF development following total laryngectomy surgery with total thyroidectomy and bilateral elective cervical lymph node dissection level I-IV. In spite of conservative treatment, the fistula was not recovered after 3 weeks. It was decided to perform fibrin glue injection into the fistula tract via the endoscopic approach. One month after the fibrin glue injection, no evidence of contrast extravasation was observed on barium swallow test, and the fistula was completely closed. Conclusion No PCF has been treated with fibrin glue using only the endoscopic technique. The present study showed that fibrin glue can be used as an effective way to treat chronic fistulas in head and neck surgeries.Introduction Thyroid gland fibrosarcomas are extremely rare tumors, and only very few cases have been described in the literature. There are no set recommendations along with follow-ups regarding the treatment of these tumors. Moreover, the prognosis is poor with a very short life expectancy. Case Report We present an 81-year-old patient who was suffering from increasing dysphagia and dysphonia related to a painless giant cervical mass, which presented with progressive growth for the preceding months. After a core needle biopsy with a suspicion of a solitary fibrous tumor, total excision of the tumor was successfully performed, and the pathology examination revealed a fibrosarcoma. Following surgery, radiotherapy was decided in the oncological multidisciplinary meeting; however, the patient refused it. There were neither new clinical symptoms nor tumor recurrence after an 18-month follow-up. Conclusion Although it is a very rare tumor, primary fibrosarcoma of the thyroid gland should be kept in mind in the differential diagnosis of neck tumors.Introduction Isolated sphenoid sinus inflammatory diseases (ISSIDs) are responsible for about 75% of isolated sphenoid sinus opacifications. Computer tomography (CT) and magnetic resonance imaging (MRI) should be used in a complementary manner for the assessment of ISSIDs. This evaluation sheds some light on the extent of disease and intracranial and intra-orbital involvement. Materials and Methods The current study aimed to evaluate the medication histories of 14 patients who underwent endoscopic sinus surgery (ESS) for ISSIDs within 2015-2018. This assessment was carried out to analyze the presenting symptoms, diagnostic work-up, additional therapies, and complications. Moreover, it can help us compare our data with pertinent literature. Results As evidenced by the obtained results, ISSID lesions included bacterial sphenoiditis (42.9%), fungus ball (21.4%), invasive fungal sphenoiditis (14.3%), mucocele (14.3%), and retention cysts (7.1%). In addition, headache was found to be the major complaint, followed by nasal symptoms. Diplopia, and signs and symptoms of the involvement of other cranial nerves were less frequent. All patients underwent endoscopic transnasal sphenoidectomy. The overall survival rate was reported as 92.9% (13/14), and all patients with cranial nerve palsies demonstrated complete clinical remission. Conclusion Both the review of related literature and our clinical cases were indicative of the dangerous consequences of ISSIDs. Their varied and unspecific presentation and the limited reliability of nasal endoscopy required the cooperation of ENT (ear, nose, and throat) team with other specialists to make an accurate diagnosis and decide on the most appropriate therapeutic choices. If the signs of intracranial complications were detected, surgery should be promptly performed to maximize the chances of recovery.Introduction Cervicofacial cellulitis can be rapidly complicated with a difficult airway when prompt management is not instituted. It may have some serious consequences for developing baby when a pregnant woman is involved. This study presented the experiences gained from the management of cervicofacial cellulitis in pregnant women. Materials and Methods The present study was conducted on 18 pregnant women with cervicofacial cellulitis affecting more than one facial space at the presentation in a regional tertiary hospital within a five-year period (January 2013 to December 2017). The collected information included patient age, clinical diagnosis, number of involved facial spaces, gestational periods, and duration of hospital stay. The collected data were analyzed using SPSS software (version 15.0). Results A total of 131 patients with cervicofacial cellulitis were admitted during the study period, out of which 18 patients met the inclusion criteria and were investigated in the present study. These 18 patients were within the age range of 20-43 years with the mean age of 29±7.1 years. There was a statistically significant relationship between the number of fascial spaces involved and duration of hospital stay (P=0.04). All the patients had incision and drainage of the affected facial spaces under local anesthesia with good outcomes. Conclusion The prompt management of pregnant women with cervicofacial cellulitis in a multidisciplinary manner is important to ensure uneventful outcomes in the lives of both the pregnant woman and unborn child.Introduction The present study aimed to investigate the audiological profiles of elementary school-age children in Rasht, Iran, and estimate the prevalence of hearing impairments in this population. Materials and Methods In this cross-sectional descriptive-analytical study, the hearing threshold was screened using pure tone audiometry (PTA). Hearing impairment was defined as equal to or higher than 20 dB HL. see more Results of the hearing thresholds were separately reported in the left or right ears and better or worse ears. Logistic regression tests were used to investigate the association between hearing loss and possible risk factors. In this study, all the analyses were conducted using SPSS software (version 21). Results The present study was carried out on a total of 2019 children. Mean age of the participants was reported as 9.66±1.66 years. Based on low-frequency pure-tone average, the prevalence rates of hearing loss > 15 dB in the right and left ears were reported as 1.94% and 1.68%, respectively. The high-frequency hearing loss > 15 dB in the right and left ears was obtained at 1.
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