Notes

Pan-Cancer Investigation Shows Frequent and Specific Connections among Intragenic miRNAs and Their Number Family genes.
005 µg cm-2 versus Group B = 0.033 µg cm-2) (P = 0.018). Significantly lower skin exposure was measured on the palm (P = 0.017), wrist (P = 0.017), forehead (P = 0.027) of Group A workers compared with Group B. No significant difference was found for the urinary platinum excretion of the two groups (Group A GM = 0.208 µg g-1 creatinine versus Group B GM = 0.361 µg g-1 creatinine) (P = 0.273).

The use of disposable coveralls and long-sleeved rubber gloves, along with strict usage procedures, proved effective in reducing precious metals refinery workers' skin exposure to soluble platinum.
The use of disposable coveralls and long-sleeved rubber gloves, along with strict usage procedures, proved effective in reducing precious metals refinery workers' skin exposure to soluble platinum.
Remote ischaemic preconditioning (RIPC) has been shown to have a protective role on vital organs exposed to reperfusion injury. The aim of this systematic review was to evaluate the effects of non-invasive RIPC on clinical and biochemical outcomes in patients undergoing non-cardiac surgery.

A systematic literature search of PubMed, EMBASE, Scopus, and Cochrane databases was carried out in February 2020. RCTs investigating the effect of non-invasive RIPC in adults undergoing non-cardiac surgery were included. Meta-analyses and trial sequential analyses (TSAs) were performed on cardiovascular events, acute kidney injury, and short- and long-term mortality.

Some 43 RCTs including 3660 patients were included. The surgical areas comprised orthopaedic, vascular, abdominal, pulmonary, neurological, and urological surgery. Meta-analysis showed RIPC to be associated with fewer cardiovascular events in non-cardiac surgery (13 trials, 1968 patients, 421 events; odds ratio (OR) 0.68, 95 per cent c.i. 0.47 to 0.96; fect.While conjugate vaccines against typhoid fever have recently been recommended by the World Health Organization for deployment, the lack of a vaccine against paratyphoid, multidrug resistance and chronic carriage all present challenges for the elimination of enteric fever. In the past decade, the development of in vitro and human challenge models has resulted in major advances in our understanding of enteric fever pathogenesis. In this review, we summarise these advances, outlining mechanisms of host restriction, intestinal invasion, interactions with innate immunity and chronic carriage, and discuss how this knowledge may progress future vaccines and antimicrobials.
The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (226n-3) before the onset of AD symptoms, particularly in APOE-ε4 carriers. Selleck SR18662 Brain alterations in the preclinical stage can be detected by structural MRI.

We aimed, in middle-aged cognitively unimpaired individuals at increased risk of AD, to cross-sectionally investigate whether dietary DHA intake relates to cognitive performance and to MRI-based markers of cerebral small vessel disease and AD-related neurodegeneration, exploring the effect modification by APOE-ε4 status.

In 340 participants of the ALFA (ALzheimer and FAmilies) study, which is enriched for APOE-ε4 carriership (n=122, noncarriers; n=157, 1 allele; n=61, 2 alleles), we assessed self-reported DHA intake through an FFQ. We measured cognitive performance by administering episodic memory and executive function tests. We performed high-resolution structural MRI to assess cerebral smrom DHA supplementation in the preclinical stage.This trial was registered at clinicaltrials.gov as NCT01835717.
In cognitively unimpaired APOE-ε4 homozygotes, dietary DHA intake related to structural patterns that may result in greater resilience to AD pathology. This is consistent with the current hypothesis that those subjects at highest risk would obtain the largest benefits from DHA supplementation in the preclinical stage.This trial was registered at clinicaltrials.gov as NCT01835717.Many diseases that affect modern humans fall in the category of complex diseases, thus called because they result from a combination of multiple aetiological and pathogenic factors. Regardless of the organ or system affected, complex diseases present major challenges in diagnosis, classification, and management. Current forms of therapy are usually applied in an indiscriminate fashion based on clinical information, but even the most advanced drugs only benefit a limited number of patients and to a variable and unpredictable degree. This 'one measure does not fit all' situation has spurred the notion that therapy for complex disease should be tailored to individual patients or groups of patients, giving rise to the notion of 'precision medicine' [PM]. Inflammatory bowel disease [IBD] is a prototypical complex disease where the need for PM has become increasingly clear. This prompted the European Crohn's and Colitis Organisation to focus the 7 th Scientific Workshop on this emerging theme. The articles in this special issue of the Journal address the various complementary aspects of PM in IBD, including what is PM; why it is needed and how it can be used; how PM can contribute to prediction and prevention of IBD; how IBD PM can aid in prognosis and improve response to therapy; and the challenges and future directions of PM in IBD. This first article of this series is structured on three simple concepts [what, why, and how] and addresses the definition of PM, discusses the rationale for the need of PM in IBD, and outlines the methodology required to implement PM in IBD in a correct and clinically meaningful way.
The current study explores whether personal social network characteristics are associated with older adults' memory and/or social cognitive function (e.g., ability to infer other's mental states - theory of mind).

120 older adults completed a social network interview, a memory measure, and two core measures of social cognitive functions emotion recognition and theory of mind.

Variation in memory and social cognitive abilities predicted distinct aspects of older adults' social networks. Having better memory predicted having larger, less dense social networks, but better theory of mind was associated with having at least one acquaintance in the network, and having more heterogeneous social relationships within the network.

Together our findings suggest that disparate social cognitive abilities may serve unique functions, facilitating maintenance of beneficial social connections.
Together our findings suggest that disparate social cognitive abilities may serve unique functions, facilitating maintenance of beneficial social connections.
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