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Affected individual encounters associated with alcohol consumption expert health care worker treatments inside a common clinic, and also onwards attention pathways.
As gauged by the Drummond checklist, the quality of CTN published economic evaluations were found to improve over time, and recent published articles were identified as guides to cutting-edge economic research. As the CTN continues to grow and mature, it is imperative that high-quality economic evaluations are incorporated alongside trials in order to maximize the public health impact of the CTN. INTRODUCTION The "Women and Trauma" Study (WTS) conducted in the National Drug Abuse Treatment Clinical Trials Network (CTN-0015) resulted in research publications, presentations, and a train-the-trainer workshop to support dissemination efforts for skills-based trauma treatment in substance use community treatment. Twelve years after its completion, this paper aims to examine whether and how the WTS contributed to knowledge in the field of trauma and addictions and inspired community treatment programs (CTPs) to train staff to identify and provide trauma-related services. METHOD We present findings from two different analyses that explored longer term study impacts on treatment and dissemination (1) a post-study site survey covering 4 domains from 4/7 programs that participated in delivering the WTS to evaluate their perceptions of study impact on their treatment community; and (2) an analysis of citations of its publications to determine impact on the scientific community. RESULTS Surveys from responding sites indicated that participation in the study significantly increased their agencies'' awareness of the need to take a focused approach to treating trauma issues in this population. Specifically, these sites increased their commitment to using skills-based trauma treatment with the study's target population of female patients with SUD and trauma histories, as well as expanding it to other groups affected by trauma. Citation analysis revealed that according to the Web of Science, as of August 2019, the number of citations of 24 CTN-0015 articles, ranged from 1 to 135 (Mean = 20, SD = 33; Median = 6). Four of the most influential are discussed. read more CONCLUSIONS This manuscript provides original information about the contributions of the WTS study, demonstrating how the study contributed to serving women with trauma in community substance use treatment. Jim Carrey, comedian and actor, succinctly explains much of this month's Book Forum in his metaphorical children's book How Roland Rolls. On the surface, this bedtime story is about a wave who fears his end once he meets the shore. Carrey presents a reassuring afterlife for the anxious little wave, by explaining that once Roland and the other waves crash into many pieces, rather than disappear, they become part of something even better. Results of randomized controlled trials (RCTs) and, ideally, the synthesis of RCT results into meta-analyses, drive both clinical and policy decision making about health care interventions and inform new avenues for research. Selection of the right health outcomes to measure, analyze, and report on when designing a trial therefore is key in ensuring that the research will be useful and will have maximum impact.1-3 As in many areas of medicine, wide variability exists in pediatric mental health research as to which outcomes are selected, how they are measured, and how they are reported. Variability in outcome selection and measurement may stem from various factors, including a tendency to select what is feasible or historical to measure rather than a focus on what is important to measure and how best to measure it. The resulting variability limits comparing and combining the results from different trials addressing a similar question in meta-analyses, hindering the translation of research to practice.1,2 The objective of this article is to highlight the importance of outcome selection, measurement, and reporting in the translation of research to clinical practice. We thank Aristodemou and Fried1 for their thoughtful comments on our article about changes in the psychopathology bifactor dimensions over a psychosocial intervention.2 Aristodemou and Fried expressed concerns over our interpretation of the p factor and our selection of the bifactor model over alternative models. We will address each concern and highlight the issues they raise for the field more broadly. Crown All rights reserved.One of the most discussed recent topics in psychopathology research is the p factor of mental illness. This single dimension is understood to measure "a person's liability to mental disorder, comorbidity among disorders, persistence of disorders over time, and severity of symptoms."1 A recent paper by Constantinou et al.2 published in the Journal investigated the external validity of the p factor. We commend the authors for the contribution to the literature and want to highlight two points (1) the interpretation of p as a causal entity, and (2) selection of bifactor models over alternative models for reasons of superior fit. STATEMENT OF PROBLEM If the components in the acrylic resins used to fabricate interim crows are cytotoxic, they can interfere with the integrity of the adjacent periodontal tissue and the dentin-pulp complex. PURPOSE The purpose of this in vitro study was to assess the cytotoxicity of resin-based materials used to prepare interim crowns. MATERIAL AND METHODS The following materials were used in this study CAR, conventional acrylic resin powder and liquid; BR, bis-acrylic resin; and PAR, pressed acrylic resin of the CAD-CAM type. Glass disks were used as the control (Co). Oral epithelial cells (NOK) were seeded on glass disks and standardized disks prepared with the resins under study. After incubation for 24 hours, the cells were analyzed for viability (Alamar Blue and Live or Dead), adhesion, and morphology (SEM and fluorescence), as well as epidermal growth factor synthesis (EGF-ELISA). The surface roughness (Ra) of test specimens was evaluated under a confocal microscope. The data were submitted to ANOVA and the Tukey HSD statistical tests (α=.05). RESULTS The highest Ra value was observed in BR in comparison with CAR, PAR, and Co (P less then .05). The highest viability, adhesion, and EGF synthesis values were determined for the cells in contact with PAR (P less then .001). CONCLUSIONS The computer-aided design and computer-aided manufacturing (CAD-CAM)-type resin favored adhesion, metabolism, and epithelial cell proliferation, and it was therefore considered cytocompatible.
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