Notes

Bulk spectrometry-based top-down along with bottom-up systems for proteomic analysis of the Moroccan Buthus occitanus scorpion venom.
These categories shed light, through bivariate and Poisson regression analyses, on the potential risk factors relative to court decisions. Results demonstrate that reverse burden of proof and insufficient evidence as the basis for judgment were, respectively, risk factors for conviction and acquittal of veterinary practitioners, and the number of lawsuits increased by 533 % over eight years. Soils are crucial trace evidence that can establish or exclude the relationship between a suspect, victim, or an object at a particular scene, which could contribute to building a case. Laser-induced breakdown spectroscopy (LIBS) and Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy have been demonstrated to be effective techniques for soil characterization owing to its being rapid, non-destructive, and convenient analysis with little sample preparation requirements. Therefore, the principles of LIBS and FTIR-ATR techniques for soil forensic analysis in typical soil samples were investigated and their practical feasibility was tested by applying the techniques to forensic soil samples in two criminal cases. Principal component analysis (PCA) of a typical soil sample indicated that five typical soil types were clearly distinguished by LIBS and FTIR-ATR spectra. Variations in the soil elements (i.e., Si, Mg, Al, Ca, K, O, and N) and functional groups (i.e., OH/NH, CC/CO, SiO, CO32-, AlOH, and NH2) are crucial indicators for soil identification. The casework results demonstrated that both LIBS and FTIR-ATR show great potential for forensic soil analysis in future cases. OBJECTIVES To assess knowledge and practice of birth preparedness among antenatal care (ANC) clients attending maternal and child health center in Assiut Governorate in Upper Egypt and to identify factors affecting BP/CR knowledge and practice. METHODS A cross sectional study was conducted in three randomly selected health centers providing ANC services in Assiut city, Upper Egypt. 300 pregnant women in their third trimester were interviewed using an Arabic version of the BP/CR questionnaire. Bivariate and logistic regression analyses were performed to identify the predictors of BP/CR knowledge and practice of pregnant women. RESULTS Only 26.7% of the study participants were considered "well prepared" for birth and its complications. The most frequently mentioned practice was the preparation of essential items for delivery and newborn care (40%) followed by saving money (34.7%). Identifying a skilled provider for delivery, a blood donor and a transport method was practiced only by 7.3%, 2.3% and 1% of the participants respectively. Women who lived in rural regions were 1.9 times likely to be well prepared for childbirth than those who lived in urban regions and women who attended ≥4 ANC visits were 3.2 times more likely to be well prepared as compared to those who attended less than four visits. CONCLUSION Efforts should focus not only on frequency but also on the contents of health education given during ANC follow ups with giving special emphasis to knowledge of key danger signs and BP/ CR. Since the advent of biologics in human welfare various bio-molecules have been explored. Different bacterial exopolysaccharides have proved their worth in many industrial and commercial applications. In this perspective, while exploring a surfactant exopolysaccharide of Ochrobactrum pseudintermedium C1, it is strikingly observed that it possesses a potent antibacterial property which encourages its bio-medical applications. Following isolation and purification of the said exopolysaccharide, its structural configuration and functional attributes are studied by several analytical procedures involving FTIR, 13C- NMR, CHN-analysis, estimation of zeta potential, XRD-study and digital tensiometry. When treated with pathological samples in vitro, it distinctly elicits its antibacterial property by exhibiting a characteristic zone of inhibition. Combined with a standard antibiotic (like ciprofloxacin), it enhances the action of antibiotic also. Mechanism of its antibacterial action is evaluated by crystal violet entrapment assay with UV-vis spectrophotometry, bacterial cell viability assay by trypan blue staining and SEM study. Results show that its basic surfactant property, anionic character, crystalline nature and scaffolding architecture are supposed to facilitate its antibacterial property which is manifested by its capability of disrupting bacterial cell envelope causing eventual cell death. In the current global scenario, an increasing threat of antibiotic resistance is prevailing due to their indiscriminate use. BGT226 in vivo If used as an adjuvant with a judicious dose of antibiotic, this bio-molecule might play a significant role in bio-medicine to combat such threat. BACKGROUND Low level of fibrinogen is a risk factor of perioperative bleeding, which is a major complication in surgical patients. However, the safety and efficacy of fibrinogen supplementation with fibrinogen concentrate to minimize postoperative bleeding remains unclear. OBJECTIVES The primary aim of this review was to investigate the effect of fibrinogen concentrate in postoperative blood loss in adult surgical patients. DESIGN Systematic review and meta-analysis. DATA SOURCES Databases of MEDLINE, EMBASE and CENTRAL were searched from their start date until July 2019. ELIGIBILITY CRITERIA All randomized clinical trials comparing intravenous fibrinogen concentrate and placebo in adult surgical patients were included, regardless of type of surgery. Observational studies, case reports, case series and non-systematic reviews were excluded. RESULTS Thirteen trials (n = 900) were included in this review. In comparison to placebo, fibrinogen concentrate significantly reduced the first 12-hour postoperative blood loss, with a mean difference of -134.6 ml (95% CI -181.9 to -87.4). It also significantly increased clot firmness in thromboelastometry (FIBTEM) with a mean difference of 2.5 mm (95%CI 1.1 to 3.8). No significant differences were demonstrated in the adverse events associated with fibrinogen concentrate use, namely incidence of thromboembolism, myocardial infarction and acute kidney injury. CONCLUSIONS In this meta-analysis of 13 randomized trials, low level of evidence and substantial heterogeneity with small sample size limit strong recommendation on the use of fibrinogen concentrate in adult surgical patients. However, its use is tolerable without any notable adverse events. TRIAL REGISTRATION CRD42019149164.
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