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Greater maximum output may possibly increase talk acknowledgement using bone fragments conduction listening to gadgets.
In the present work, a wireless microfluidic sensor based on low-temperature cofired ceramic (LTCC) technology for real-time detection of metal ions in water is proposed. The wireless sensor is composed of a planar spiral inductor and parallel plate capacitor (LC) resonant antenna, which integrates with the microchannel in the LTCC substrate between the capacitor plates. Aqueous solutions of Pb(NO3)2, Cd(NO3)2, Mg(NO3)2, Ca(NO3)2, NaNO3, and KNO3 with concentrations of 0-100 mM were tested with the sensors. The metal ion and its concentration in water can be tested by the amplitude of the reflection coefficient (S 11) and the resonance frequency (f r) of the wireless microfluidic sensor. The metal ion species can be distinguished from the wireless response behavior of the sensor. The detection limit of the sensor for the selected metal ionic solutions could reach as low as 5 μM. The normalized sensitivity of the sensor is 0.47%, which is higher than that of the reported liquid microfluidic sensors based on microwave resonators. The wireless microfluidic sensor of this study is promising for rapid and convenient detection of heavy metal ion pollutants in the industrial wastewater.Organic light-emitting diodes (OLEDs) suffer from poor light outcoupling efficiency (ηout less then 20%) due to large internal waveguiding in the high-index layers/substrate, and plasmonic losses at the metal cathode interface. A promising approach to enhance light outcoupling is to utilize internal periodic corrugations that can diffract waveguided and plasmonic modes back to the air cone. Although corrugations can strongly diffract trapped modes, the optimal geometry of corrugations and limits to ηout are not well-established. We develop a general rigorous scattering matrix theory for light emission from corrugated OLEDs, by solving Maxwell's equations in Fourier space, incorporating the environment-induced modification of the optical emission rate (Purcell effect). We computationally obtain the spectrally emissive power inside and outside the OLED. We find conformally corrugated OLEDs, where all OLED interfaces are conformal with a photonic crystal substrate, having triangular lattice symmetry, exhibit high light outcoupling ηout ∼60-65%, and an enhancement factor exceeding 3 for optimal pitch values between 1 and 2.5 μm. Waveguided and surface plasmon modes are strongly diffracted to the air cone through first-order diffraction. ηout is insensitive to corrugation heights larger than 100 nm. There is a gradual roll-off in ηout for a larger pitch and sharper decreases for small pitch values. Plasmonic losses remain below 10% for all corrugation pitch values. Our predicted OLED designs provide a pathway for achieving very high light outcoupling over the full optical spectrum that can advance organic optoelectronic science and solid-state lighting.Antibacterial photodynamic therapy (aPDT) utilizes reactive oxygen species such as singlet oxygen (1O2) and free radicals via photosensitizers, which are light and light-sensitive agents, to reduce bacterial infections. It has been utilized as a treatment for dental diseases in place of antibiotic therapies. However, aPDT does not always cause the desired therapeutic effect due to the instability of organic photosensitizers and the formation of bacterial biofilms. To promote the antibacterial and antibiofilm effects of aPDT, we have proposed a lysozyme (Lys)-gold nanoclusters (Au NCs)/rose bengal (Lys-Au NCs/RB) conjugate as a novel photosensitizer. This conjugate was found to effectively impede the growth of both gram-positive and gram-negative bacteria when exposed to white light-emitting diode (LED) irradiation. The photoexcited Lys-Au NCs/RB showed significantly higher antibacterial activity than photoexcited Lys-Au NCs or RB alone. The synergistic effect is a result of the combination of Lys (an antibacterial protein) and enhanced 1O2 generation related to resonance energy transfer (RET) in the Au NCs/RB conjugate. Photoexcited Lys-Au NCs/RB increased the effects of aPDT in a dose- and time-dependent manner. Furthermore, the photoexcited Lys-Au NCs/RB successfully decreased Streptococcus mutans biofilm formation. However, in contrast, it did not have a negative effect on the proliferation, adhesion, or spread of mammalian cells, indicating low cytotoxicity. Lys-Au NCs/RB is a novel photosensitizer with low cytotoxicity that is capable of bacterial inactivation and the suppression of biofilm formation, and could help to improve dental treatments in the future.Hydroxyapatite nanoparticle-complexed collagen (HAP/Col) hydrogels have been widely used in biomedical applications as a scaffold for controlled drug release (DR). The time-variant mechanical properties (Young's modulus, E) of HAP/Col hydrogels are highly relevant to the precise and efficient control of DR. However, the correlation between the DR and the E of hydrogels remains unclear because of the lack of a nondestructive and continuous measuring system. To reveal the correlations, herein, we investigate the time-variant behavior of E for HAP/Col hydrogels during 28 days using the atomic force microscopy (AFM) nanoindentation technique. The initial E of hydrogels was controlled from 200 to 9000 Pa by the addition of HAPs. Subsequently, we analyzed the relationship between the DR of the hydrogels and the changes in their mechanical properties (ΔE) during hydrogel degradation. iJMJD6 concentration Interestingly, the higher the initial E value of HAP/Col hydrogels is, the higher is the rate of hydrogel degradation over time. However, the DR of hydrogels with higher initial E appeared to be significantly delayed by up to 40% at a maximum. The results indicate that adding an appropriate amount of HAPs into hydrogels plays a crucial role in determining the initial E and their degradation rate, which can contribute to the properties that prolong DR. Our findings may provide insights into designing hydrogels for biomedical applications such as bone regeneration and drug-delivery systems.Employing π-conjugated anionic groups in molecular construction has been proven to be an effective strategy to find superior ultraviolet (UV) nonlinear optical (NLO) crystals over the decades. Herein, unlike the traditional π-conjugated anionic groups, we identify that a π-conjugated cationic group, viz., [C(NH2)3]+, is also an excellent UV NLO-active functional group in theory. Furthermore, we identify a [C(NH2)3]+-containing compound, C(NH2)3ClO4, as a promising UV NLO candidate due to its short UV cutoff edge (200 nm), remarkable second-harmonic generation effect (∼3 × KDP), and moderate birefringence of 0.076@1064 nm. Additionally, C(NH2)3ClO4 has excellent ferroelectric properties and reversal of domains, which also enables it to produce ultraviolet coherent light as short as 200 nm by a quasi-phase matching technique with a periodically poling method. Our study may provide not only a promising UV NLO crystal but also a new π-conjugated functional unit, [C(NH2)3]+, which will open a path to finding new classes of high-performance UV NLO crystals.
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