Notes

Trehalose-based neuroprotective autophagy inducers.
This paper introduces a novel technique for the development of custom polydimethylsiloxane (PDMS) vessels for use in phantom technologies. The method involves continuous dip coating of commercial silicone tubes with rapid curation in a single controlled process. The technique accommodates the production of different vessel diameters, wall thicknesses (56 µm-80 µm) and mechanical properties. Clear phantoms were fabricated to compare the commercial silicone tubes against the customs vessels. A pulsatile fluidic pump (BDCLabs, CO, USA) driven by a computer controlled linear motor generated the pulsatile flow through the phantom. The resulting flow profile, using the custom vessels, simulates human blood flow and the detected contact PPG signal from the phantom closely resembles the morphology of in vivo PPG waveforms with signal-to-noise ratios of 38.16 dB and 40.59 dB, compared to the closest commercially-available tubing at 5.38 dB and 10.59 dB for the red and infrared wavelengths respectively. AUY-922 mw The rigidity and thick walls of commercial silicone tubes impede the expansion of the tubing under systolic pressure. This technique eliminates this common limitation in phantom development.This paper introduces a low-cost phantom system that simulates fetal movements (FMVs) for the first time. This vibration system can be used for testing wearable inertial sensors which detect FMVs from the abdominal wall. The system consists of a phantom abdomen, a linear stage with a stepper motor, a tactile transducer, and control circuits. The linear stage is used to generate mechanical vibrations which are transferred to the latex abdomen. A tactile transducer is implemented to add environmental noise to the system. The system is characterized and tested using a wireless sensor. The sensor recordings are analyzed using time-frequency analysis and the results are compared to real FMVs reported in the literature. Experiments are conducted to characterize the vibration range, frequency response, and noise generation of the system. It is shown that the system is effective in simulating the vibration of fetal movements, covering the full frequency and magnitude ranges of real FMV vibrations. The noise generation test shows that the system can effectively create scenarios with different signal-to-noise ratios for FMV detection. The system can facilitate the development of fetal movement monitoring systems and algorithms.Capnometry is a method to measure carbon dioxide (CO2) in exhaled gas and has been used to monitor patient's respiratory status. During moderate or deep sedation, monitoring for the presence of exhaled CO2 is recommended for evaluating the adequacy of ventilation. Oxygen administration is usually given to patients with a nasal cannula to avoid hypoxia during sedation. However, the flow of oxygen administration can interfere with CO2 measurement. We developed a nasal cannula type adapter called cap-ONE nasal adapter system based on the mainstream capnography which is designed to monitor CO2 while supplying oxygen. In this study, we evaluated the basic performance of the system as compared with a conventional device using a spontaneous breathing model. The cap-ONE nasal adapter system could accurately measure PetCO2 without being disturbed by oxygen flow and efficiently supply oxygen.Capnometry is a method to measure carbon dioxide (CO2) in exhaled gas and it has been used to monitor patient respiratory status. CO2 monitoring is also used for patients receiving non-invasive positive pressure ventilation (NPPV) therapy during mechanical ventilation. Ventilators actively dilute exhaled gas during non-invasive ventilation. In order to accurately measure end-tidal CO2, an adequate amount of expired gas needs to be filled in a CO2 measurement cell before expiratory positive airway pressure (EPAP) gas from the ventilator arrives to the cell. This is the reason why it is difficult to measure CO2 stably during non-invasive ventilation using the conventional CO2 measurement method. Therefore, we developed NPPV cap-ONE mask, which accurately measures CO2 in exhaled gas during non-invasive ventilation. In this study, we evaluated the basic performance of the NPPV cap-ONE mask system. The NPPV cap-ONE mask system could accurately measure CO2 in exhaled gas comparing to the conventional device in this study.This work presents a modelling approach to predict the blood pressure (BP) waveform time series during activities of daily living without the use of a traditional pressure cuff. A nonlinear autoregressive model with exogenous inputs (NARX) is implemented using artificial neural networks and trained to predict the BP waveform time series from electrocardiography (ECG) and forehead photoplethysmography (PPG) input signals. To broaden the range of blood pressures present in the training set, a protocol was implemented that included sitting, standing, walking, Valsalva manoeuvers, and static handgrip exercise. A five-minute interval of data in the sitting position at the end of the day was also used for training. The efficacy of the cuffless BP method for continuous BP estimation over 4.67 hours was evaluated on 3 participants for varying training data segments. A mean absolute error of 6.3 and 5.2 mmHg were achieved for systolic BP and diastolic BP estimates, respectively. Including static handgrips and Valsalva manoeuvers in the training dataset leads to better estimation of the higher ranges of BP observed throughout the day. The proposed method shows potential for estimating the range of BP experienced during activities of daily living.Clinical Relevance- Establishes a method for cuffless continuous blood pressure estimation during activities of daily living that can be used for continuous monitoring and acute hypertension detection.The US and European guidelines for the diagnosis and management of hypertension recommend the introduction of systematic home and night Blood Pressure (BP) monitoring. Fully-automated wearable devices can address the needs of patients and clinicians by improving comfort while achieving measurement accuracy. Often located at the wrist and based on indirect BP measurements, these devices must address the challenges of ambulatory scenarios. New validation strategies are needed, but little guidance has been published so far.In this work, we propose an experimental protocol for the validation of cuffless wrist BP monitors that addresses ambulatory environment challenges in a controlled experimental setting. The protocol assesses the robustness of the measurement for different body postures, the ability of the device to track BP changes, and its ability to deal with hydrostatic pressure changes induced by different arm heights.Performance testing using Aktiia Bracelet is provided as an illustration. The results of this pilot study indicate that the Aktiia Bracelet can generate accurate BP estimates for sitting and lying positions and is not affected by hydrostatic pressure perturbations.
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