Notes

An organized review of euthyroid Graves' disease (Review).
Studies on individual unicondylar endoprosthetics and robotics are reporting promising results. However, long-term results of high-quality randomized studies must be awaited in order to make ascientifically sound statement.
The use of robotics in endoprosthetics makes it easier to correctly perform bone resections and align components. This ensures high and reproducible precision even for surgeons with lower case numbers. Studies on individual unicondylar endoprosthetics and robotics are reporting promising results. However, long-term results of high-quality randomized studies must be awaited in order to make a scientifically sound statement.
Ahigher patient satisfaction stands in contrast to higher revision rates of unicondylar knee joint endoprosthetics (UKE) compared to total knee joint endoprosthetics (TKE). Furthermore, old "dogmas" regarding indications and contraindications persist, which is still reflected in the significantly different case numbers.

The aim of this article is to provide an overview of the current literature regarding 1.indication and contraindication (BMI, age, sport, arthrosis of other compartments, ligament status) and 2.the "eternal rival" fixed or mobile bearing for UKE.

The choice of the right patient remains essential, even if all the old "dogmas" of contraindications have been relativized or even outdated. Arthroses of the contralateral (in medial UKE correspondingly lateral) compartment and advanced arthroses of the lateral patella facet remain the only persistent contraindications. In contrast, ahigh BMI, age, chondrocalcinosis, medial patella facet and adefective (but particularly functionally stable) ACL are not contraindications; however, severe obesity is responsible for asignificantly higher complication rate and probably ahigher rate of loosening. Rather, the experience and thus the number of UKEs of the individual surgeon is decisive for the outcome, to which the discussion about mobile or fixed inlays must also be completely subordinated.

The indications for UKE can, therefore, be extended with aclear conscience on the basis of literature, and the current 110UKETKE ratio in Germany can be shifted significantly.
The indications for UKE can, therefore, be extended with a clear conscience on the basis of literature, and the current 110 UKETKE ratio in Germany can be shifted significantly.
Localized cartilage lesions or osteochondral defect areas of the hip joint often affect young patients with an active professional and personal live. There are multiple causes of these defect zones, but they determine the therapeutic options to some extent.

In addition to the domain of joint-preserving, implant-free hip surgery, so-called mini-prostheses or partial implants represent another treatment strategy prior to the application of a total hip arthroplasty (THA). In the following, partial joint resurfacing implants (e.g., HemiCAP®, Arthrosurface, Franklin, MA, USA) are presented and results from the literature are cited. The described procedure is not widely offered, especially in Germany, because most indications are congruent with those for implantation of a THA, which is an established technique. Consequently, the results from the literature are based on case series with inferior validity compared to the studies and registry data of the THA and accordingly have to be scrutinized in a more critica an established technique. Consequently, the results from the literature are based on case series with inferior validity compared to the studies and registry data of the THA and accordingly have to be scrutinized in a more critical way. Total surface replacement (hip resurfacing, e.g., Birmingham hip replacement, BHR, Smith and Nephew, Memphis, TN, USA) distinguish from partial surface replacement. On the one hand the BHR shows parallels with regard to the femoral surface reconstruction, but on the other hand due to the obligatory replacement of the acetabular side of the joint it meets conditions of THA, which can therefore play at best an intermediate role between a stem-anchored THA and a partial replacement.In recent years process modelling has become an established method which generates digital twins of manufacturing plant operation with the aid of numerically solved process models. This article discusses the benefits of establishing process modelling, in-house or by cooperation, in order to support the workflow from process development, piloting and engineering up to manufacturing. The examples are chosen from the variety of botanicals and biologics manufacturing thus proving the broad applicability from variable feedstock of natural plant extracts of secondary metabolites to fermentation of complex molecules like mAbs, fragments, proteins and peptides.Consistent models and methods to simulate whole processes are available. To determine the physical properties used as model parameters, efficient laboratory-scale experiments are implemented. These parameters are case specific since there is no database for complex molecules of biologics and botanicals in pharmaceutical industry, yet.Moreover, Quality-by-Design approaches, demanded by regulatory authorities, are integrated within those predictive modelling procedures. The models could be proven to be valid and predictive under regulatory aspects. Process modelling does earn its money from the first day of application. Process modelling is a key-enabling tool towards cost-efficient digitalization in chemical-pharmaceutical industries.Digital methods for process design, monitoring, and control can convert classical trial-and-error bioprocess development to a quantitative engineering approach. Ruxotemitide manufacturer By interconnecting hardware, software, data, and humans currently untapped process optimization potential can be accessed. The key component within such a framework is a digital twin interacting with its physical process counterpart. In this chapter, we show how digital twin guided process development can be applied on an exemplary microbial cultivation process. The usage of digital twins is described along a typical process development cycle, ranging from early strain characterization to real-time control applications. Along an illustrative case study on microbial upstream bioprocessing, we emphasize that digital twins can integrate entire process development cycles if the digital twin itself and the underlying models are continuously adapted to newly available data. Therefore, the digital twin can be regarded as a powerful knowledge management tool and a decision support system for efficient process development.
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