Notes

Using Innovative Strategies to Predictive Management within Tasks Regarding Intelligent Metallic Processing Generation Systems.
531, p =  0.008) and Glx (r = 0.511, p =  0.018) in PFC. Physical fatigue was negatively correlated with GABA+ in SMC and PFC (r = -0.428 and -0.472 respectively, p ≤  0.04) and positively with PFC Glx (r = 0.480, p =  0.028).

The associations between fatigue and GABA + and Glx suggest that there might be dysregulation of GABAergic/glutamatergic neurotransmission in the pathophysiological mechanism of central fatigue in MS.
The associations between fatigue and GABA + and Glx suggest that there might be dysregulation of GABAergic/glutamatergic neurotransmission in the pathophysiological mechanism of central fatigue in MS.The toughening mechanism of cortical bone is closely related to its hierarchical microstructure. Osteon is the most important microstructure of cortical bone. Therefore, it is very important to study the toughening mechanism of the microstructure of osteon. There are three main kinds of cracks in cortical bone external crack of osteon, internal radial cracks of osteon and microporous damage cracks. ALK assay Numerical models for these three kinds of cracks are established by XFEM and the progressive damage approach, respectively. The multi-toughening mechanisms of microstructure of osteon are found. The cement line on the outside of osteon is its first toughening mechanism, which can make the crack deflection and improve the fracture resistance of osteon. The resistance of cement line to fracture increases with the decrease of the strength and the increase of the thickness. The second toughening mechanism is elliptical osteocyte lacunae, which can attract the crack into the elliptical lacunae and cause stress redistribution to prevent the crack propagation. The annularly elliptical lacuna structure is an optimized arrangement and shape of microstructure, which is the third toughening mechanism of osteon. This microstructure can determine the location of the crack initiation and make the microcracks propagate along the annular direction rather than penetrating into the haversian cannal to protect the integrity of the osteon. The study of these toughening mechanisms provides new ideas for the research and design of synthetic composite structures.An Eye Tracking System (ETS) is used at CNAO for providing a stable and reproducible ocular proton therapy (OPT) set-up, featuring a fixation light (FL) and monitoring stereo-cameras embedded in a rigid case. The aim of this work is to propose an ETS set-up simulation algorithm, that automatically provides the FL positioning in space, according to patient-specific gaze direction and avoiding interferences with patient, beam and collimator. Two configurations are provided one in the CT room for acquiring images required for treatment planning with the patient lying on a couch, and one related to the treatment room with the patient sitting in front of the beam. Algorithm validation was performed reproducing ETS simulation (CT) and treatment (room) set-up for 30 patients previously treated at CNAO. The positioning accuracy of the device was quantified through a set of 14 control points applied to the ETS case and localizable both in the CT volume and in room X-ray images. Differences between the position of ETS reference points estimated by the algorithm and those measured by imaging systems are reported. The corresponding gaze direction deviation is on average 0.2° polar and 0.3° azimuth for positioning in CT room and 0.1° polar and 0.4° azimuth in the treatment room. The simulation algorithm was embedded in a clinically usable software application, which we assessed as capable of ensuring ETS positioning with an average accuracy of 2 mm in CT room and 1.5 mm in treatment room, corresponding to gaze direction deviations consistently lower than 1°.
To simulate radiofrequency (RF) burns that frequently occur at skin-skin and skin-bore wall contact points.

RF burn injuries (thumb-thigh and elbow-bore wall contacts) that typically occur on the lateral side of the body during 1.5T magnetic resonance imaging (MRI) scans were simulated using a computational human model. The model was shifted to investigate the influence of the position of the patient in an MRI scanner. The specific absorption rate (SAR), electric field, and temperature were mapped.

Regarding the contact points located near the edge of the birdcage transmission coil, under the allowable maximum RF power exposure i.e., the average whole-body SAR at the safety limit value (2W/kg), the 10-g-tissue-averaged SAR (SAR
) at those points significantly increased for both the thumb-thigh (180W/kg) and elbow-bore wall (48W/kg) cases. Both values significantly exceeded the highest safety limit of the partial-body SAR (10W/kg). The electric field, the square of which is proportional to SAR, was remarkably high near the edge of the birdcage transmission coil. The peak SAR
for each injury case was associated with contact-point peak temperatures that reached 52°C at approximately 1min following RF exposure onset; a 1-min period of exposure to this temperature causes a first-degree burn.

We demonstrated high heat generation in RF burn injury cases in silico. The RF heating occurring on the lateral side of the body was strongly dependent on the electric field distribution, which is dominantly determined by an RF transmission coil.
We demonstrated high heat generation in RF burn injury cases in silico. The RF heating occurring on the lateral side of the body was strongly dependent on the electric field distribution, which is dominantly determined by an RF transmission coil.Uranium (U) geochemistry and its isotopic compositions of reservoir sediments in U mine area were poorly understood. Herein, U and Th isotopic compositions were employed to investigate source apportionment and geochemical behavior of U in 41 reservoir sediments from a U mining area, Guangdong, China. The remarkably high contents of both total U (207.3-1117.7 mg/kg) and acid-leachable U (90.3-638.5 mg/kg) in the sediments exhibit a severe U contamination and mobilization-release risk. The U/Th activity ratios (ARs) indicate that all sediments have been contaminated apparently by U as a result of discharge of U containing wastewater, especially uranium mill tailings (UMT) leachate, while the variations of U/Th ARs are dominated by U geochemical behaviors (mainly redox process and adsorption). The U isotopic compositions (δ238U) showed a large variance through the sediment profile, varying from - 0.62 to - 0.04‰. The relation between δ238U and acid-leachable U fraction demonstrates that the U isotopic fractionation in sediments can be controlled by bedrock weathering (natural activity), UMT leachate (anthropogenic activity) and subsequent biogeochemical processes.
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