Notes

Biocementation mediated simply by ancient microorganisms through Brahmaputra riverbank regarding mitigation of soil erodibility.
ith primary treatment failure, and 8.3 months (±2.5) in those with secondary treatment failure.

Our data show slightly higher persistence levels in patientswith psoriasis and lower discontinuation rates in those without previousexposure to biological therapy. Long-term studies are needed to confirmthese findings and to gain a better understanding of the factors that caninfluence persistence of secukinumab.
Our data show slightly higher persistence levels in patients with psoriasis and lower discontinuation rates in those without previous exposure to biological therapy. Long-term studies are needed to confirm these findings and to gain a better understanding of the factors that can influence persistence of secukinumab.
To assess the general healthcare impact of a Biological TherapiesCommitee (immune-mediated inflammatory diseases) through prescriptionhabits, pre-biological studies and immunization.

A quasi-experimental study was conducted on all naïvepatients of legal age who started treatment with a biological agent for animmune- mediated inflammatory disease the year before and the year afterthe creation of the Biological Therapies Committee.

A total of 31 patients treated in 2016 and 40 patients treated in2018 were included. Prescriptions of tumor necrosis factor alpha inhibitordrugs decreased in 2018 (from 80.6% to 45.0%, p < 0.05), while prescriptionsof interleukin 12/23 inhibitors increased (from 12.9% to 35.0%,p < 0.05). Tuberculosis screening was statistically different between thetwo periods the number of interferon gamma release assays performedwas higher in 2018 (from 9.7% to 80.0%, p < 0.01) and the proportionof patients who successfully underwent chemoprophylaxis was higher in2018 (from 36.4% to 81.8%, p < 0.05). The proportion of tests requestedfor the study of viral pathologies and the number of vaccines administeredwere also higher in 2018.

The development of a specific Biological Therapies Committeeallows healthcare improvements, contributing to a deeper understandingof the medications and to preventing the infection-related adverseevents. It would therefore seem advisable to develop specialized committeesakin to the Biological Therapies Committee in other domains.
The development of a specific Biological Therapies Committee allows healthcare improvements, contributing to a deeper understanding of the medications and to preventing the infection-related adverse events. It would therefore seem advisable to develop specialized committees akin to the Biological Therapies Committee in other domains.
The objective of this study was to assess the results ofapplying Lean Methodology in the design of a standardized medicationstorage model in hospitalization departments.

Descriptive and retrospective study conducted between September2017 and January 2019 in a tertiary level hospital. The PharmacyService led the creation of a multidisciplinary team. Lean Methodologywas used to establish the components and organization and identificationcriteria that made up the standardized medication storage model. Thestocks of each hospitalization department were reviewed and quantified,the final amount of stock needed was agreed with the supervisor of eachdepartment, and the economic impact of the implementation of the standardizedmedication model was assessed. A questionnaire was designedand sent to nursing staff to determine their level of satisfaction with thenew model.

The standardized medication storage model was scaled up to20 nursing departments, leading to an overall reduction of 56.72% in thenumber of pharmacs to economic savings and a marked reduction in the number of active ingredients and high-risk medications. The nursing staff were satisfied with the implementation of the model, suggesting that we should continue to pursue this effective line of action.Drug attrition rate is the calculation or measure of the clinical efficacy of a candidate drug on a screen platform for a specific period. Determining the attrition rate of a prospective cancer drug is a reliable way of testing the clinical efficacy. A low attrition rate in the last phase of a preclinical trial increases the success of a drug discovery process. It has been reported that the attrition rates of antineoplastic drugs are much higher than for other therapeutic drugs. Among the factors identified for the high attrition rates in antineoplastic drugs are the nature of the screen-based platforms involving human-derived xenografts, extracellular matrix-derived scaffold systems, and the synthetic scaffolds, which all have propensity to proliferate tumor cells at faster rates than in vivo primary tumors. Other factors that affect the high attrition rates are induced scaffold toxicity and the use of assays that are irrelevant, yet affect data processing. These factors contribute to the wide variation in dctively.
To determine circulating levels of antibodies (IgA, IgM, IgG1-4) in individuals with SCI as compared to uninjured individuals.

Prospective, observational study.

Outpatient clinic of a Department of Physical Medicine and Rehabilitation and research institute in an academic medical center.

Individuals with chronic (≥ 1 year from injury) SCI and uninjured individuals.

Serum antibody titers were determined by commercial multiplex ELISA.

Blood samples were collected from individuals with chronic SCI (
 = 29, 83% males) and uninjured individuals (
 = 25, 64% males). Among participants with SCI, the distribution of American Spinal Injury Association Impairment Scale (AIS) grades was A (
 = 15), B (
 = 2), C (
 = 4), D (
 = 8). Neurological levels of injury were cervical (
 = 17), thoracic (
 = 10), and lumbar (
 = 2). Daurisoline supplier IgA levels were significantly elevated in participants with SCI compared to uninjured participants (median 1.98 vs. 1.21 mg/ml, P < 0.0001), with levels most elevated in individfurther investigations of IgA and other antibody types in individuals with chronic SCI, which may be increasingly important in the context of emerging novel infectious diseases such as SARS-CoV-2.
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