Notes

Social Support as well as Longevity: Meta-Analysis-Based Proof as well as Psychobiological Mechanisms.
To assess the effect of extraoral polishing of the crown-abutment interface on the marginal fit of implant-supported screw- and cement-retained prostheses (SCRPs).

In 31 patients, the marginal gap of an SCRP was measured using a stereomicroscope before and after polishing of the crown-abutment interface, and the paired data were compared.

The marginal gap was significantly decreased after surface polishing regardless of the prosthesis material (P < .001).

Extraoral polishing of the crown-abutment interface could improve the marginal fit of SCRPs.
Extraoral polishing of the crown-abutment interface could improve the marginal fit of SCRPs.
To evaluate the effectiveness of liquid disinfectant soaps for the reduction of microorganisms present on maxillary complete dentures.

The selected patients (N = 28) were randomly divided into four groups (n = 7), and each group underwent all four disinfection treatments in a different order. The disinfection treatments evaluated were 0.5% sodium hypochlorite (positive control); Dettol liquid soap; Lifebuoy liquid soap; and phosphate-buffered saline solution (negative control). The patients were instructed to immerse their maxillary dentures in the disinfectant solution for 8 hours (overnight) for 7 days, with the solutions in a randomized sequence with a washout period of 1 week between solutions. Biofilm samples of the dental prostheses were obtained before and after each treatment with a sterile swab, and the microbiologic material was diluted and plated in selective media for Candida spp. Colony-forming unit count (CFU/mL) was performed in each group. One-way ANOVA with Welch correction was used for analysis, with Games-Howell post hoc test with a significance level of .05.

A 3-log reduction in microorganisms was considered effective compared to baseline. IGF-1R inhibitor The highest incidence observed was for Candida albicans, which presented with a frequency between 66% and 92%, followed by C tropicalis, with a frequency between 7% and 33%, in all experimental groups. Sodium hypochlorite was able to reduce more than 3 log
of microorganisms for all patients, showing high antifungal effectiveness for both C albicans and C tropicalis species. Regarding the experimental groups, both liquid soaps (Dettol and Lifebuoy) were effective in reducing the two types of microorganisms.

Liquid soaps were effective at reducing biofilm and may be an alternative for disinfection of removable partial dentures or complete dentures.
Liquid soaps were effective at reducing biofilm and may be an alternative for disinfection of removable partial dentures or complete dentures.
To test the applicability of coded healing abutments, intraoral scanners, and monolithic zirconia for the fabrication of three-unit fixed dental prostheses (FDPs) on two dental implants.

Patients with three missing teeth in the posterior region of either the maxilla or mandible received two dental implants. After healing, coded healing abutments were placed. Full-arch intraoral scans were made to produce individual titanium abutments and a three-unit FDP. Peri-implant tissues were assessed 2 weeks after placement of the FDP and again after 1 year. Patient-reported outcome measures were registered prior to treatment and after 1 year. The quality of the FDPs was assessed using modified United States Public Health Service criteria after 1 year of service.

A total of 54 patients were treated with 60 restorations, and 51 patients with 56 restorations were available at the 1-year follow-up. Implant survival was 99.1%, and prosthesis survival was 100%. The peri-implant tissues remained healthy, and patient satisfaction was high. However, the USPHS evaluation showed that some prostheses exhibited fit or color issues that needed to be addressed, although most were rated as successful (80.4%).

The use of coded healing abutments and intraoral scanners to produce full-zirconia three-unit FDPs on two dental implants proved to be a feasible technique, with promising objective and subjective results. However, technical challenges still impacted the treatment results, resulting in a number of restorations having clinical or radiographic marginal gaps or reduced color match.
The use of coded healing abutments and intraoral scanners to produce full-zirconia three-unit FDPs on two dental implants proved to be a feasible technique, with promising objective and subjective results. However, technical challenges still impacted the treatment results, resulting in a number of restorations having clinical or radiographic marginal gaps or reduced color match.We retrospectively analyzed preoperative serum CA153, carcinoembryonic antigen (CEA) and white blood cells (WBC) in 121 breast cancer patients who underwent breast-conserving therapy and sentinel lymph node biopsy (SLNB) between June 2017 and April 2019 in our institution. The receiver operating characteristic curve (ROC curve) was used to determine the optional cut-offs of these biomarkers for predicting SLN metastasis. The relationship between the parameters to SLN metastasis of breast cancer was assessed by univariate analysis and multivariate logistic regression models. We finally enrolled 121 breast cancer patients who all underwent SLNB, of whom 56 were confirmed as positive SLN by histopathology. ROC curve analysis calculated an ideal CA153 cutoff value of 7.85 U/ml in prediction of SLN metastasis, with a sensitivity of 73.2%, and specificity of 67.7%. The ideal cutoff value for CEA to predict SLN metastasis was 1.66 ng/ml (sensitivity 67.9%, specificity 73.8%). CA153 combined with CEA showed specificity 78.6% and specificity 76.9%. CA153 and CEA combined with WBC presented sensitivity 80.4% and specificity 78.5%. In the multivariate logistic regression analysis, CA153 (odds ratio (OR) 1.165, 95% confidence interval (CI) 1.061-1.279, P less then 0.001) and CEA (OR 3.440, 95% CI 1.859-6.366, P less then 0.001) were independent predictive factors of SLN metastasis in patients with breast cancer.[This retracts the article on p. 2082 in vol. 13, PMID 32922604.].
Ischemic tolerance is an endogenous protective mechanism in organs or tissues undergoing one or more short-term sublethal ischemias. Intermittent hypobaric hypoxia preconditioning (IHHP) can induce tolerance and thus protect brain tissues from cerebral ischemic injury (CIR). The current study evaluated the neuroprotective effect of IHHP.

The established xenograft model was divided into the ischemia/reperfusion (I/R), IHHP, IHHP+I/R, and sham groups. Transmission electron microscopy was used to observe alterations in neuron ultrastructure. Neuron damage was detected using Nissl staining. Western blot and qRT-PCR were used to evaluate the relative expression of genes and proteins related to apoptosis. Immunohistochemistry was used to determine the expression of proteins involved in the processes of neuroprotection and repair.

Our results indicated that the damage to the neurons, organelles, and axons was significantly less following ischemia/reperfusion and intermittent hypobaric hypoxia reconditioning treatment than that in the ischemia/reperfusion group.
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