Notes

Phytochemical Portrayal and also Look at Bioactive Components associated with Tisanes Prepared coming from Promising Medical along with Fragrant Plant life.
Triple-negative breast cancer (TNBC) is the subtype of breast cancer with more aggressive growth and metastasis and without efficient therapies. Hence, it is worthwhile to search for potential effective drug candidates. According to our previous study, isoliquiritigenin (ISL) exerted a potent anticancer effect on breast cancer proliferation. Its effect on TNBC growth, metastasis and mechanism deserves further investigation. In this study, PCR array screened a significant increase of miR-200c in BT-549 and MDA-MB-231 cells after ISL treatment, and ISH exerted that miR-200c was expressed at a low level in breast cancer tissue of patients. We also found that ISL could up-regulate miR-200c, resulting in the inhibition of epithelial-mesenchymal transition. Meanwhile, ISL could inhibit metastasis and tumor growth in nude mice models through the increase of miR-200c. Further study displayed that ISL decreased c-Jun expression through the increase of miR-200c. Interestingly, we also detected that ISL might increase miR-200c expression through the demethylation of miR-200c promoter region. These findings indicated that ISL could be potentially developed as a novel drug candidate for TNBC in microRNA-based cancer therapies.How do Adolescents see their Parents? Prevalences, Predictors and Relationships in Longitudinal and Cross-Section Research The parent-child relationship has a significant influence on the psychological and social development of a young person in adolescence. The parental image from the perspective of the adolescent has rarely been examined. The aim of this study is to examine the parental images of adolescents in terms of family cohesion, conflicts and overprotection for differences between the paternal and the maternal images and between girls and boys. Furthermore, a cross-section examines the relationship between the parental images and psychological disorders, and, in a longitudinal 10-year study, whether the parental images can be predicted through risk factors in childhood. The sample includes 343 young people with an average age of 14 years, 46 % are girls. The parental images were recorded with the "Elternbildfragebogen" (Parental Image Questionnaire; EBF-KJ; Titze u. Lehmkuhl, 2010). Compared to fathers, mothers are assessed more positively in terms of their cohesion, but at the same time they also show more conflictual and higher overprotection behavior. Very few differences were found between girls and boys. There were consistently significant correlations between the parental images and internalizing and externalizing symptomatology, such that cohesion is a protective factor and conflicts and overprotection are risk factors for the development of psychological disorders. Some aspects of the images of the mother and father can be significantly predicted by the parents' education and by psychological disorders in childhood. Future research should examine the influence of possible mediators and moderators.Overweight/Obesity of Children and Adolescents and its Association with Internalising and Externalising Disorders Research in child and adolescent psychiatry increasingly deals with the association between mental disorder and weight. This paper provides an overview of national and international studies on the relationship between body composition and mental illness in children and adolescents, with a focus on the representation of individual internalizing and externalizing disturbance patterns. The majority of studies in this area are based on the so-called one-compartment model of body composition in terms of the Body Mass Index (BMI) or on the classification as "overweight" or "obese". Associations between mental disorders and body composition were described in two directions On one hand, both externalising and internalising symptoms are associated with obesity, and on the other hand there are also more psychopathological symptoms among overweight children and adolescents. Longitudinal studies suggest effects in both directions. selleck screening library While externalising symptoms and weight are thought to be related from infancy on, this connection seems to be evident for internalising disorders not earlier than for early school age. It is also known from the literature that psychopharmacological medication affects weight and body growth - especially with psychostimulants, but also with neuroleptics and antidepressants. We found only a few studies describing the relationship between body composition and psyche in more complex models with two or more compartments.Leisure Opportunities for Autistic Children and Adolescents How Satisfied are Parents and what do they Think their Children Would Like? Like all children and youth, autistic children and adolescents have the right to participate in cultural life including recreational, leisure and sporting activities. Therefore, arrangements have to be made to ensure access to these areas for these particular population (Art. 30 UN-BRK, §§76, 78 BTHG). Thus far, no research has been conducted that examines the need for leisure time facilities for autistic children and/or adolescents in Germany. Therefore, it is unclear if an equal participation in leisure time opportunities is provided. This study presents a first assessment of this topic based on an online-survey of parents of autistic children and adolescents (N = 327). The results indicate, that there is a substantial need for leisure opportunities. Parents of children with infantile and atypical autism show a greater need for more leisure opportunities than parents of children with Asperger Syndrome. In general, the findings show that an equal participation has not been achieved yet. Overall, there is a need for (small) group and sporting activities and especially younger parents asked for specific experiential environments. Possible approaches to a need-oriented organization of leisure facilities for autistic children and adolescents and for an enhancement of leisure opportunities are discussed. The paper further outlines the need for more research in order to provide an empirical basis for equal participation possibilities in public life for autistic children and adolescents.
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