Notes

Transcardiac Perfusion of a mouse button regarding Human brain Tissue Dissection and Fixation.
Ripples are common in both biological systems and human clothes. Knitters have long exploited the ability of fabric to curl out of plane, by either removing or adding stitches to the material as it is created. Here, we present two knitting patterns for scarves to illustrate how ripples can arise through such additive processes.Based on keynote at the 4th International Conference on Administrative Data, Cardiff, UK, December 10, 2019.This article is a personal reflection on a professional journey from ethnographer to keen analyst of administrative data. Using a knitter's analogy, I describe using the thread of administrative information, armed with one stick (social science methods) and the second stick, practice-relevant, theory-informed research.This opinion piece provides insight on the creation of artistic visuals using artificial intelligence. It describes how 3 artists evolving in this field decided to use technology in a derived way, with the help of researchers and enthusiasts working open source, to talk about how our society is developing with regards to technology adoption.Class-prediction accuracy provides a quick but superficial way of determining classifier performance. selleck inhibitor It does not inform on the reproducibility of the findings or whether the selected or constructed features used are meaningful and specific. Furthermore, the class-prediction accuracy oversummarizes and does not inform on how training and learning have been accomplished two classifiers providing the same performance in one validation can disagree on many future validations. It does not provide explainability in its decision-making process and is not objective, as its value is also affected by class proportions in the validation set. Despite these issues, this does not mean we should omit the class-prediction accuracy. Instead, it needs to be enriched with accompanying evidence and tests that supplement and contextualize the reported accuracy. This additional evidence serves as augmentations and can help us perform machine learning better while avoiding naive reliance on oversimplified metrics.In multi-criteria recommender systems, matrix factorization characterizes users and items via latent factor vectors inferred from user-item rating patterns. However, two-dimensional matrix factorization models may not be able to cope with the recommendation problem that involves additional criterion-specific rating data. This study introduces a tensor factorization method to handle three-dimensional user-item-criterion rating data. Moreover, we observe that using single global tensor factorization alone may not be sufficient to characterize diverse preferences among different groups of users, and a combined global and local tensor factorization method (GLTF) for multi-criteria recommendation is thus proposed. One key benefit of the GLTF is that it can leverage global user-item-criterion rating patterns while also exploiting local user-subset specific rating behaviors to jointly infer the latent factor representations for users, items, and specific item criteria. Experimental results, which used real-life data available to the public, demonstrated that the GLTF is superior to well-established baseline methods.AI must understand human limitations to provide good service and safe interactions. Standardized data on human limits would be valuable in many domains but is not available. The data science community has to work on collecting and aggregating such data in a common and widely available format, so that any AI researcher can easily look up the applicable limit measurements for their latest project.The intersection of medicine and machine learning (ML) has the potential to transform healthcare. We describe how physiology, a foundational discipline of medical training and practice with a rich quantitative history, could serve as a starting point for the development of a common language between clinicians and ML experts, thereby accelerating real-world impact.Data provenance is a machine-readable summary of the collection and computational history of a dataset. Data provenance confers or adds value to a dataset, helps reproduce computational analyses, or validates scientific conclusions. The people of the End-to-End Provenance Project are a community of professionals who have developed software tools to collect and use data provenance.DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide "snapshot" of >450,000 observations (probe measurements) per assay. However, the reliability of each of these measurements is not equal, and little consideration is paid to consequences for research. We correlated repeat measurements of the same DNA samples using the Illumina HumanMethylation450K and the Infinium MethylationEPIC BeadChips in 350 blood DNA samples. Probes that were reliably measured were more heritable and showed consistent associations with environmental exposures, gene expression, and greater cross-tissue concordance. Unreliable probes were less replicable and generated an unknown volume of false negatives. This serves as a lesson for working with DNA methylation data, but the lessons are equally applicable to working with other data as we advance toward generating increasingly greater volumes of data, failure to document reliability risks harming reproducibility.Analyzing coordination environments using X-ray absorption spectroscopy has broad applications in solid-state physics and material chemistry. Here, we show that random forest models trained on 190,000 K-edge X-ray absorption near-edge structure (XANES) spectra can identify the main atomic coordination environment with a high accuracy of 85.4% and all associated coordination environments with a high Jaccard score of 81.8% for 33 cation elements in oxides, significantly outperforming other machine-learning models. In a departure from prior works, the coordination environment is described as a distribution over 25 distinct coordination motifs with coordination numbers ranging from 1 to 12. More importantly, we show that the random forest models can be used to predict coordination environments from experimental K-edge XANES with minimal loss in accuracy. A drop-variable feature importance analysis highlights the key roles that the pre-edge and main-peak regions play in coordination environment identification.
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