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Porous Pt electrocatalysts have been developed as an example of carbon-free porous metal catalysts in anticipation of polymer electrolyte membrane (PEM) fuel cells and PEM water electrolyzers through the assembly of the metal precursor and surfactant. In this study, porous Pt was structurally evaluated and found to have a porous structure composed of connected Pt particles. The resulting specific electrochemical surface area (ECSA) of porous Pt was 12.4 m2 g-1, which was higher than that of commercially available Pt black. Accordingly, porous Pt showed higher oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) activity than Pt black. When the activity was compared to that of a common carbon-supported electrocatalyst, Pt/ketjen black (KB), porous Pt showed a comparable ORR current density (2.5 mA cm-2 at 0.9 V for Pt/KB and 2.1 mA cm-2 at 0.9 V for porous Pt), and OER current density (6.8 mA cm-2 at 1.8 V for Pt/KB and 7.0 mA cm-1 at 1.8 V), even though the ECSA of porous Pt was only one-sixth that of Pt/KB. Moreover, it exhibited a higher durability against 1.8 V. In addition, when catalyst layers were spray-printed on the Nafion® membrane, porous Pt displayed more uniform layers in comparison to Pt black, showing an advantage in its usage as a thin layer.Purpose To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma. Methods Records of 615 patients treated for choroidal melanoma between January 2017 and December 2019 were reviewed. Patients were excluded if iris and/or ciliary body involvement (106 patients), inadequate fundus photography (26 patients), no images available for review (21 patients) and/or treatment was not primary (11 patients). Demographic data and AJCC TNM Stage were collected. Color fundus and autofluorescence photographs (FAF), optical coherence tomography (OCT) and B-scan ultrasounds were prospectively reviewed. MOLES scores were assigned according to five criteria mushroom shape, orange pigment, large size, enlarging tumor and subretinal fluid. Results A total of 451 patients (mean age, 63.9 ± 13.9 years) were included. At treatment, mean largest basal tumor diameter (LBD) and thickness were10.3 ± 2.8 mm (range, 3.0-23.0) and 4.3 mm (range, 1.0-17.0). All but one (0.2%) had MOLES scores of ≥3. Eighty-two patients were treated after surveillance lasting a mean of 1.5 years. Initially, most (63/82; 76.8%) had a MOLES score ≥ 3. Importantly, none of the 451 tumors had a score of less then 2, and as such, the MOLES protocol would have indicated referral to an ocular oncologist for 100% of patients. Conclusion The MOLES scoring system is a sensitive (99.8%) tool for indicating malignancy in melanocytic choroidal tumors (MOLES ≥ 3). If the examining practitioner can recognize the five features suggestive of malignancy, MOLES is a safe tool to optimize referral of melanocytic choroidal tumors for specialist care.This article examines autonomous reconnaissance in a complex urban environment using unmanned aerial vehicles (UAVs). Environments with many buildings and other types of obstacles and/or an uneven terrain are harder to be explored as occlusion of objects of interest may often occur. First, in this article, the problem of autonomous reconnaissance in a complex urban environment via a swarm of UAVs is formulated. Then, the algorithm based on the metaheuristic approach is proposed for a solution. This solution lies in deploying a number of waypoints in the area of interest to be explored, from which the monitoring is performed, and planning the routes for available UAVs among these waypoints so that the monitored area is as large as possible and the operation as short as possible. CCT245737 chemical structure In the last part of this article, two types of main experiments based on computer simulations are designed to verify the proposed algorithms. The first type focuses on comparing the results achieved on the benchmark instances with the optimal solutions. The second one presents and discusses the results obtained from a number of scenarios, which are based on typical reconnaissance operations in real environments.In this work, the microstructure and mechanical properties of an additively manufactured X3NiCoMoTi18-9-5 maraging steel were determined. Optical and electron microscopies revealed the formation of melt pool boundaries and epitaxial grain growth with cellular dendritic structures after the laser powder bed fusion (LPBF) process. The cooling rate is estimated to be around 106 °C/s during solidification, which eliminates the nucleation of any precipitates. However, it allows the formation of austenite with a volume fraction of about 5% and dendritic structures with primary arm spacing of 0.41 ± 0.23 µm. The electron backscatter diffraction analysis showed the formation of elongated grains with significant low-angle grain boundaries (LAGBs). Then, a solutionizing treatment was applied to the as-printed samples to dissolve all the secondary phases, followed by aging treatment. The reverted austenite was evident after heat treatment, which transformed into martensite after tensile testing. The critical plastic stresses for this transformation were determined using the double differentiation method. The tensile strength of the alloy increased from 1214 MPa to 2106 MPa after the aging process due to the formation of eta phase. The experimental data were complemented with thermodynamic and mechanical properties simulations, which showed a discrepancy of less than 3%.Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.
My Website: https://www.selleckchem.com/products/cct245737.html
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