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Useful censoring on account of missing info inside total well being ended up being insufficiently considered generally in most oncology randomized manipulated tests.
2 accompanied by low-expression of p21 was observed in lung cancer tissues and associated with lower overall survival. CONCLUSION Taken together, our study find a new regulatory pathway of p21, in which miR-509-3-5p functionally interacts with NONHSAT112228.2 to release p21 expression. MiR-509-3-5p-NONHSAT112228.2 regulatory axis can inhibit proliferation and migration of lung cancer cells. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] sclerosis (MS) is the most common autoimmune demyelinating disease of the central nervous system (CNS). learn more It is a multifactorial disease which develops in an immune-mediated way under the influences of both genetic and environmental factors. Demyelination is observed in the brain and spinal cord leading to neuro-axonal damage in patients with MS. Due to the infiltration of different immune cells such as T-cells, B-cells, monocytes and macrophages, focal lesions are observed in MS. Currently available medications treating MS are mainly based on two strategies; i) to ease specific symptoms or ii) to reduce disease progression. However, these often tend to induce different adverse effects with limited therapeutic efficacy due to the protective function of the blood-brain barrier. Therefore, researchers have been working for last four-decades to discover better solutions by introducing gene therapy approaches in treating MS generally by following three strategies, i) prevention of specific symptoms, ii) halt or reverse disease progression and iii) heal CNS damage by promoting remyelination and axonal repair. In last two decades, there have been some remarkable successes of gene therapy approaches on the experimental mice model of MS - experimental autoimmune encephalomyelitis (EAE) which suggests that it's not far that the gene therapy approaches would start in human subjects ensuring the highest levels of safety and efficacy. In this review, we summarised the gene therapy approaches attempted in different animal models towards treating MS. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Evidences have increasingly indicated that human disease, cell metabolism are deeply associated with proteins. Structural mutations and dysregulations of these proteins would contribute to the development of complex disease. Free radicals are unstable molecules that they look for electrons from surrounding atoms for stability, Once a free radical binds to an atom in the body, a chain reaction occurs, which causes damage to cells and DNA. Antioxidant protein is a substance that protects cells from free radical damage. Accurate identification of antioxidant proteins is important for understanding their role in delaying aging and preventing and treating related diseases.Therefore, computational methods to identify pantioxidant proteins have become an effective prior-pinpointing approach to the experimental verification. METHODS In this study, we use support vector machines to identify antioxidant proteins, using amino acid compositions and 9-gap dipeptide compositions as feature extraction, and featurmpared with the existing classification model, it is further explained that the SVM recognition model constructed in this paper is helpful for the recognition of antioxidized proteins. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] is a chronic inflammatory vascular disease. Atherosclerotic cardiovascular diseases are the main reason of death in both developed and developing countries. Many pathophysiological factors, such as abnormal cholesterol metabolism, vascular inflammatory response and endothelial dysfunction, vascular smooth muscle cell proliferation and apoptosis, contribute to the development of atherosclerosis; whereas the molecular mechanisms underlying the development of atherosclerosis remains to be fully understood. Ubiquitination is a multi-step post-translational protein modification process, participating in many important cellular processes. Emerging evidence suggests that ubiquitination plays important roles in the pathogenesis of atherosclerosis through many aspects including a regulation of vascular inflammation, endothelial cell and vascular smooth muscle cell function, lipid metabolism and atherosclerotic plaque stability. This review summarizes important contributions of various E3 ligases to the development of atherosclerosis. Targeting ubiquitin E3 ligases may provide us a newly strategy to prevent the progression of atherosclerosis. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] To conduct a systematic review and meta-analysis of prospective studies investigating the improvement effects of natto on bone mineral density in perimenopausal women. Design Systematic review and meta-analysis.Data sources PubMed, EMBASE and Cochrane database searched up to February 2019. REVIEW METHODS This study was carried out according to the PRISMA guidelines10 for systematic reviews. The protocol of the review was registered in the PROSPERO registry (CRD42019133183). RESULTS The review identified 3 unique prospective studies comprising 1658 non-overlapping participants. Meta-analysis showed that natto could significantly improve lumbar bone mineral density (BMD) (P=0.002, WMD=0.26). 95% CI0.09-0.43) in cohort studies. However, the randomized controlled study showed no statistical difference between the two (P=0.31, WMD=0.05; 95% CI-0.05-0.15). In addition natto significantly improve the BMD of femoral neck in cohort study and randomized control study (P=0.03, WMD=0.42). 95% CI0.05-0.79, I2= 7large-sample and high-quality RCT studies are needed to further clarify the improvement effect of natto on osteoporosis. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole derivatives have broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the 2-pyrazoline derivatives possess potent anticancer activities. In present review, it covers the pyrazoline derivatives reported by literatures from 2010 till date (2010-2019). This review aims to establish the relationship between the anticancer activities variation and different substituents introduced into 2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer agents that containing 2-pyrazoline scaffold. Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
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