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Nephrological knowledge of the complications of hypoalbuminemia and "resistance" to diuretics must lead to an early implementation of renal replacement procedures in order to be able to prevent mechanical ventilation in COVID-19 intensive care patients with increased extracellular lung fluid. The kidneys can be used as a seismograph for severe courses of COVID-19 and nephrological knowledge can be brought to use to optimize the intensive medical care for critically ill patients. Both together have the potential to considerably reduce morbidity and mortality further.Between 15 August and 7 December 2020, 561highly pathogenic avian influenza (HPAI) virus detections were reported in 15EU/EEA countries and UK in wild birds, poultry andcaptive birds, with Germany (n=370), Denmark (n=65), the Netherlands (n=57) being the most affected countries.The majority of the detections have been reported in wild birds(n=510), primarily in barnacle goose, greylag goose, andEurasian wigeon. Raptors have also been detected infected, particularly common buzzard. The majority of the birds had been found dead or moribund,however, there are also reports ofHPAI virus infection in apparently healthy ducks or geese.A total of 43 HPAI outbreaks were notified in poultry;with signs of avian influenza infection being observed in at least 33 outbreaks;the most likely source of infection was indirect contact with wild birds. Three HPAI virus subtypes, A(H5N8) (n=518), A(H5N5) (n=17) and A(H5N1) (n=6),and four different genotypes were identified, suggesting the occurrence of multiple virus introductions1) and A(H9N2) avian influenza virus infection were reportedduring the reporting period. The risk for the general population as well as travel-related imported human cases are assessed as very low.Context. Avian influenza (AI) is an infectious viral disease that affects all species of domestic and wild birds. The viruses causing this disease can be of high (HPAI) or low (LPAI) pathogenicity and represent a continuous threat to poultry in Europe. Council Directive 2005/94/EC requires EU Member States (MSs) to carry out surveillance in poultry and wild birds and notify the results to the responsible authority. Therefore, MSs, Iceland, Norway, Switzerland and the United Kingdom have implemented ongoing surveillance programmes to monitor incursions of AI viruses in poultry and wild birds. EFSA received a mandate from the European Commission to collate, validate, analyse and summarise the data resulting from the avian influenza surveillance programmes in an annual report. Poultry. Overall 24,419 poultry establishments (PEs) were sampled, of which 87 were seropositive for H5 virus strains and 22 for H7 strains. Seropositive PEs were found in eight MSs (Belgium, Bulgaria, Denmark, France, Germany, the Netherls for poultry and wild birds for 2019 are discussed in relation to findings from previous years and current knowledge of the epidemiology of AI in Europe.Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of potassium diformate as a feed additive for sows (brand name Formi™ LHS). The additive was re-evaluated by the Panel in 2009. In its assessment on the renewal of the additive adopted by the FEEDAP Panel in 2020, the Panel concluded that the information provided by the applicant did not fulfil the minimum requirements to support that Formi™ LHS remained safe under the approved conditions for target species, consumers and users. In the same opinion, the Panel concluded that the use of Formi™ LHS under the approved conditions remained safe for the environment. In the present assessment, the applicant conducted a literature search to fulfil the data requirements for the renewal application and no relevant information regarding adverse effects in target animals (pigs, piglets and sows), consumers and users were identified. Based on this, and the fact that the manufacturing and composition of the additive have not been modified, the FEEDAP Panel considers that there is no evidence to reconsider the conclusions reached in the previous re-evaluation opinion adopted by the FEEDAP Panel in 2009. find more Therefore, the Panel concludes that the additive remains safe for sows and the consumer under the authorised conditions of use. Regarding user safety, the Panel reiterates that for the additive, 'except for ocular irritation potential, no effects requiring specific user protection measures were found'.Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety of 31 compounds belonging to different chemical groups, when used as sensory additives in feed for all animal species. Twenty-two out of the 31 compounds were tested in tolerance studies in chickens for fattening, piglets and cattle for fattening. For the remaining nine compounds, read across from structurally similar compounds was proposed. No adverse effects were observed in the tolerance studies at 10-fold the intended level. The FEEDAP Panel concluded that the 22 compounds are safe for these species at the proposed use level and conclusions were extrapolated to all animal species for all the compounds except for α-damascone [07.134]. In the absence of data that would allow the FEEDAP Panel to rule out the genotoxicity concern, the FEEDAP Panel cannot extend the conclusions for α-damascone [07.134] to all animal species and cannot conclude on the safety for the consumer, the user and the environment. No safety concern would arise for the consumer from the use of the remaining 30 compounds up to the highest levels considered safe for target animals. The revised maximum safe levels for the 30 compounds are not expected to further impact on the previous conclusions on user safety. The concentrations considered safe for the target species are unlikely to have detrimental effects on the environment for all the compounds except β-damascone [07.083] and (E)-β-damascone [07.224], for which in the absence of ecotoxicity data, the FEEDAP Panel cannot conclude on the safety for the terrestrial compartments. For the marine environment, the safe use level for 2-methyl-1-phenylpropan-2-ol [02.035], α-irone [07.011], β-damascone [07.083] and (E)-β-damascone [07.224], phenethyl isovalerate [09.466], 4-(p-hydroxyphenyl) butan-2-one [07.055] and 2-isopropyl-4-methylthiazole [15.026] is confirmed to be 0.05 mg/kg.
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