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Submillimetre structures of lung tissue are not represented in CT images used for radiotherapeutic dose calculation. In order to study the effect experimentally, lung substitutes with properties similar to lung tissue were chosen, namely two types of commercial lung tissue equivalent plates (LTEP) (CIRS, USA), two types of cork, balsawood, floral foam and konjac sponge. Laterally integrated dose profiles were measured as a function of depth (IDD) for proton pencil beams (PB) with an initial nominal energy of 97.4 and 148.2 MeV, respectively. The obtained dose profiles were investigated for their shifting and degradation of the Bragg peak (BP) caused by the materials, expressed as water equivalent thickness (WET) and full width half maximum (FWHM). The setup was simulated in the treatment planning system (TPS) RayStation using the Monte Carlo dose calculation algorithm. While the WET between experiment and dose calculation agreed within 0.5 mm, except for floral foam, the FWHM was underestimated in the TPS by up to 2.3 mm. Normalisation to the same mass thickness of the lung substitutes allowed to classify LTEPs and balsawood as homogeneous and cork, floral foam and konjac sponge as heterogeneous materials. The material specific BP degradation was up to 3.4 times higher for the heterogeneous samples. The modulation power as a measure for the heterogeneity was compared to the spectrum of Hounsfield units (HU) of the materials. A clear correlation was not found, but with further improvements the HU spectrum may serve as an indicator for the material heterogeneity. Further, MC simulations of binary voxel models using GATE/Geant4 were performed to investigate the influence of grain size and mass density. For mass densities similar to lung tissue the BP degradation had a maximum at 3 and 7 mm grain size.Atomic vacancies usually exist in the Cu-Ga-S ternary system, except for chalcopyrite CuGaS2 as a promising light-harvesting material for solar cells, and are expected to have decisive effects on the structure stability and electronic structure. We demonstrate that ordered arrangements of the straight lines locally formed by atomic vacancies prefer a stable structure through lowering the formation energy. Accidentally, we confirm that a metastable van der Waals P21/c-Cu2S phase shares better optical properties than newly-found ground-state P42-Cu2S, and possesses the photovoltaic-potentially direct band gap of 1.09 eV. Veliparib in vivo We find anomalous changes in band gap induced by varying chemical composition and applying pressure, according to the variation in p-d coupling between S and Cu atoms. Our Monte Carlo simulations together with the special quasirandom structures further suggest that the band gap of CuGaS2 can be tuned continuously from 2.51 eV for the chalcopyrite phase to 0.13 eV for the fully disordered configuration by controlling the degree of ordering, which determined by the synthesis temperature and annealing time experimentally.Brain signals refer to the biometric information collected from the human brain. The research on brain signals aims to discover the underlying neurological or physical status of the individuals by signal decoding. The emerging deep learning techniques have improved the study of brain signals significantly in recent years. In this work, we first present a taxonomy of non-invasive brain signals and the basics of deep learning algorithms. Then, we provide a comprehensive survey of the frontiers of applying deep learning for non-invasive brain signals analysis, by summarizing a large number of recent publications. Moreover, upon the deep learning-powered brain signal studies, we report the potential real-world applications which benefit not only disabled people but also normal individuals. Finally, we discuss the opening challenges and future directions.Metachronal paddling is a common method of drag-based aquatic propulsion, in which a series of swimming appendages are oscillated, with the motion of each appendage phase-shifted relative to the neighboring appendages. Ecologically and economically important Euphausiid species such as Antarctic krill (E. superba) swim constantly in the pelagic zone by stroking their paddling appendages (pleopods), with locomotion accounting for the bulk of their metabolic expenditure. They tailor their metachronal swimming gaits for behavioral and energetic needs by changing pleopod kinematics. The functional importance of inter-pleopod phase lag (ϕ) to metachronal swimming performance and wake structure is unknown. To examine this relation, we developed a geometrically and dynamically scaled robot ('krillbot') capable of self-propulsion. Krillbot pleopods were prescribed to mimic published kinematics of fast-forward swimming (FFW) and hovering (HOV) gaits of E. superba, and the Reynolds number and Strouhal number of the krillbot matched well with those calculated for freely-swimming E. superba. In addition to examining published kinematics with uneven ϕ between pleopod pairs, we modified E. superba kinematics to uniformly vary ϕ from 0% to 50% of the cycle. Swimming speed and thrust were largest for FFW with ϕ between 15%-25%, coincident with ϕ range observed in FFW gait of E. superba. In contrast to synchronous rowing (ϕ=0%) where distances between hinged joints of adjacent pleopods were nearly constant throughout the cycle, metachronal rowing (ϕ>0%) brought adjacent pleopods closer together and moved them farther apart. This factor minimized body position fluctuation and augmented metachronal swimming speed. Though swimming speed was lowest for HOV, a ventrally angled downward jet was generated that can assist with weight support during feeding. In summary, our findings show that inter-appendage phase lag can drastically alter both metachronal swimming speed and the large-scale wake structure.In this paper we propose a dual stream neural network (DSNN) for classifying arbitrary collections of functional neuroimaging signals for the purpose of brain computer interfaces (BCIs). In the DSNN the first stream is an end-to-end classifier taking raw time-dependent signals as input and generating feature identification signatures from them. The second stream enhances the identified features from the first stream by adjoining a dynamic functional connectivity matrix (DFCM) aimed at incorporating nuanced multi-channel information during specified BCI tasks. The network is tuned only once, so that fixed hyperparameters are determined for all subsequent data sets at the outset. The resulting DSNN is a subject-independent classifier that works for any collection of 1D functional neuroimaging signals, with the option of integrating domain specific information in the design. The DSNN classifier is benchmarked against three publicly available datasets, where the classifier demonstrates performance comparable to, or better than the state-of-art in each instance.
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