Notes

Disturbed Functional Rich-Club Firm with the Brain Systems in Children using Attention-Deficit/Hyperactivity Problem, any Resting-State EEG Examine.
Cancer is often treated with broad-spectrum cytotoxic drugs that not only eradicate cancerous cells, but also have detrimental side effects. One of these side-effects, disruption of the olfactory system, impedes a patient's ability to smell, perceive flavor, and ultimately may interfere with their nutritional intake and recovery from cancer. Recent studies reported that the chemotherapy drug, cyclophosphamide (CYP), can damage gustatory epithelia and disrupt cell proliferation in olfactory epithelia. In this study, we asked if CYP altered globose and horizontal basal cell proliferation in the murine main olfactory epithelium (MOE) and vomeronasal organ (VNO). We used antibodies for Ki67, a marker strictly associated with cell proliferation, and Keratin 5, a marker for the cytoskeleton of horizontal basal cells. Our results revealed a significant CYP-induced decrease in the number of proliferative cells in both epithelia, especially globose basal cells in the MOE, within the first 1-2 days post injection. Recovery of cell renewal was apparent 6 days after injection. The immunohistochemical markers showed significantly higher levels of globose and horizontal basal cell proliferation in CYP-injected mice at 14- and 30-days post-injection compared to control mice. The prolonged proliferative activation of globose and horizontal basal cells suggests that, besides altering proliferation of olfactory epithelia, the epithelial substrate needed for successful cell renewal may be adversely affected by CYP.Axial gradients in wall elasticity may have significant implications in the deformation and flow characteristics of a narrow fluidic conduit, bearing far-reaching consequences in physiology and bio-engineering. Here, we present a theoretical and experimental framework for fluid-structure interactions in microfluidic channels with axial gradients in wall elasticity, in an effort to arrive at a potential conceptual foundation for in vitro study of mirovascular physiology. Towards this, we bring out the static deformation and steady flow characteristics of a circular microchannel made of polydimethylsiloxane (PDMS) bulk, considering imposed gradients in the substrate elasticity. In particular, we study two kinds of elasticity variations - a uniformly soft (or hard) channel with a central strip that is hard (or soft), and, increasing elasticity along the length of the channel. The former kind yields a centrally constricted (or expanded) deformed profile in response to the flow. The latter kind leads to increasingly bulged channel radius from inlet to outlet in response to flow. We also formulate an analytical model capturing the essential physics of the underlying elastohydrodynamic interactions. The theoretical predictions match favourably with the experimental observations and are also in line with reported results on stenosis in mice. The present framework, thus, holds the potential for acting as a fundamental design basis towards developing in vitro models for micro-circulation, capable of capturing exclusive artefacts of healthy and diseased conditions.Late oxidation of hexose based building blocks or the use of uronic acid containing building blocks are two complementary strategies in the synthesis of glycosaminoglycans, the latter simplifiying the later stages of the process. Here we report the synthesis and evaluation of various disaccharide donors-uronic acids and their pyranose equivalents-for the synthesis of heparan sulfate, using an established protective group strategy. Hexose based "imidate" type donors perform well in the studied glycosylations, while their corresponding uronate esters fall short; a uronate ester thioglycoside performs equal to, if not better than, a hexose thioglycoside equivalent.A Pyrene-based amphiphile with C4-alkanoyl spacer and lactose (PyLac) self-assembles in the aqueous media to form an injectable hydrogel. It shows preferential binding with Cholera Toxin (CT) via its terminal galactose residue, and hence can be employed for the selective detection of CT via color-changing response.Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N-Cbz-protected l-ornithinol and l-lysinol to l-3-N-Cbz-aminopiperidine and l-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity.A nanocomposite anode material consisting of metal-organic framework (MOF)-derived hollow SiOx nanoparticles wrapped in three dimensional (3D) nitrogen-doped graphene aerogel (N-GA) has been fabricated through a facile three-step approach, involving MOF-template inducting, self-assembly and nitrogen-doping, freeze-drying and thermal treatment process. The hollow SiOx nanoparticles with an average size of 100-160 nm are distributed on 3D N-GA. Such nanocomposites possess a 3D porous structure with a BET surface area as high as 426.3 m2 g-1. In this nanostructure, the N-GA's property of interconnected porous network enables it to provide pathways for rapid electron transfer and Li+ transport, while the MOF-derived hollow SiOx nanoparticles with void space can accommodate the volume change during a lithiation/delithiation process. As a result, high rate capability (675 mA h g-1 under 50 C) as well as long-life cycling stability (1233.2 mA h g-1 under 10 C, 86% capacity retention over 500 cycles) is achieved.Two-photon active mitochondriotropic lanthanide nanorods for high resolution fluorescence imaging. The presence of Gd in the nanorods also enabled us to utilize this material as a T1-T2 dual-mode contrast reagent for recording magnetic resonance images of the mouse brain.The development of a hemostatic sponge that can be used for treating both arterial hemorrhage and non-compressible bleeding remains a challenge. In this work, we propose the fabrication of a robust hemostatic sponge by a hydrogen bond strengthening and in situ bubble expanding strategy in thermo-initiation polymerization. A thickening agent, carboxymethyl cellulose (CMC), is incorporated into a hydrogen bonding N-acryloyl-2-glycine (ACG) monomer and an initiator, and vortexing generates air bubbles in the viscous liquid. check details Heating initiates fast polymerization, and meanwhile aids in expanding of bubbles, which results in the fixation of bubbles throughout the network, and the formation of porous hydrogels. Further lyophilization of the foaming hydrogels leads to the final generation of PACG/CMC sponges with robust compressive strengths due to the hydrogen bonding interactions of PACG. PACG/CMC sponges are shown to demonstrate a tunable liquid absorption ability, in vitro hemostatic ability, better hemocompatibility and cytocompatibility.
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