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CircHIPK3 Encourages the particular Tumorigenesis and Development of Stomach Cancers By way of miR-637/AKT1 Pathway.
For biologic scientists, as for the society in general, the year 2020 was one that few will soon forget. However, in the realm of science, it is possible that it won't be remembered purely, or even mainly, for the advent of the COVID-19 pandemic and the many discoveries related to its causative agent. Even as non-SARS-related research was brought to a near standstill for much of the year, we may in time come to recognize that revolutionary work in other areas of biology was emerging unnoticed under the shadow of the virus.Maps of the nervous system inspire experiments and theories in neuroscience. Advances in molecular biology over the past decades have revolutionized the definition of cell and tissue identity. Spatial transcriptomics has opened up a new era in neuroanatomy, where the unsupervised and unbiased exploration of the molecular signatures of tissue organization will give rise to a new generation of brain maps. We propose that the molecular classification of brain regions on the basis of their gene expression profile can circumvent subjective neuroanatomical definitions and produce common reference frameworks that can incorporate cell types, connectivity, activity, and other modalities. Here we review the technological and conceptual advances made possible by spatial transcriptomics in the context of advancing neuroanatomy and discuss how molecular neuroanatomy can redefine mapping of the nervous system.The mouse, as a model organism to study the brain, gives us unprecedented experimental access to the mammalian cerebral cortex. By determining the cortex's cellular composition, revealing the interaction between its different components, and systematically perturbing these components, we are obtaining mechanistic insight into some of the most basic properties of cortical function. In this review, we describe recent advances in our understanding of how circuits of cortical neurons implement computations, as revealed by the study of mouse primary visual cortex. Further, we discuss how studying the mouse has broadened our understanding of the range of computations performed by visual cortex. Finally, we address how future approaches will fulfill the promise of the mouse in elucidating fundamental operations of cortex.Linguistic polarity is a natural characteristic of judgments Is that situation safe/dangerous? How difficult/easy was the task? Is that politician honest/dishonest? Across six studies (N = 1599), we tested how the qualitative frame of the question eliciting a risk judgment influenced risk perception and behavior intention. Using a series of hypothetical scenarios of skiing in avalanche terrain, experienced backcountry skiers judged either how safe or how dangerous each scenario was and indicated whether they would ski the scenario. Phrasing risk judgments in terms of safety elicited lower judged safety values, which in turn resulted in a lower likelihood of intending to ski the slope. The frame "safe" did not evoke a more positive assessment than the frame "danger" as might be expected under a valence-consistent or communication-driven framing effect. This seemingly paradoxical direction of the effect suggests that the question frame directed attention in a way that guided selective information sampling. Uncertainty was not required for this effect as it was observed when judging objectively safe, uncertain, and dangerous scenarios. These findings advance our theoretical understanding of framing effects and can inform the development of practices that harness question framing for applied risk perception and communication. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Although time pressure can decisively shape employees' behavior, little remains known about the consequences associated with differing perceptions of time pressure between cooperating individuals. Hence, this investigation uses two experimental studies (across different cultural contexts) to examine the joint role of a focal individual's (i.e., an actor's) and a dyadic interaction partner's time pressure perceptions for the actor's behavior toward the partner. Results demonstrated that actors' time pressure perceptions were positively related to their time-oriented behavior (i.e., pacing and synchronizing joint activities). In Study 1 (but not Study 2), the partner's time pressure moderated this association, such that the linkage between an actor's time pressure and time-oriented behavior was more pronounced when the partner experienced lower (rather than higher) time pressure. Furthermore, across both studies, the partner's time pressure perceptions moderated the linkage between an actor's time pressure and relationship-oriented behavior (i.e., being friendly and considerate). This linkage was positive when the partner experienced high time pressure, but nonsignificant (Study 1) or even negative (Study 2) when the partner experienced low time pressure. Together, these findings advance new insights into the consequences of time pressure in cooperating dyads, illustrating that conflicting time pressure perceptions may critically influence individuals' interpersonal behavior. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Pain affects the lives of many individuals by creating physical, psychological, and economic burdens. A critical psychological factor negatively affected by pain is one's ability to sustain attention. PFI-6 molecular weight In order to better understand the effect of pain on sustained attention we conducted three experiments utilizing the psychomotor vigilance task, thought probes, and pupillometry. In Experiment 1, participants in acute pain exhibited overall poorer task performance. However, this effect was localized to the relative frequency and duration of the participants' slowest responses with their faster responses being equivalent to a no-pain control group. In Experiment 2, we replicated the procedure and included periodic thought probes to overtly measure subjective experiences during the task. Participants in pain reported fewer "on-task" thoughts and more thoughts directed toward the source of their pain. In Experiment 3, we replicated the procedure while simultaneously tracking pupillary dynamics using an eye-tracker.
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