Notes

Exosomal MiR-1290 Stimulates Angiogenesis associated with Hepatocellular Carcinoma by way of Concentrating on SMEK1.
Nineteen authors received at least one industry payment relevant to the CPG recommendations for a median amount of $748 and a total of $1,961,362 in relevant payments. Of the total relevant payments received, a significant portion was undisclosed ($699,561, 35.7%). CONCLUSIONS Less than half the US-based physician CPG authors received relevant payments. Nonetheless, a substantial proportion of money received was not disclosed. Conflict of interest disclosure is a bare minimum requirement, and more permanent solutions may include divestiture or inclusion of more non-conflicted authors. This article is protected by copyright. All rights reserved.m6A modification is the most prevalent RNA modification in eukaryotes. As the critical N6-methyladenosine (m6A) methyltransferase, the roles of methyltransferase like 3 (METTL3) in colorectal cancer (CRC) are controversial. Here, we confirmed that METTL3, a critical m6A methyltransferase, could facilitate CRC progression in vitro and in vivo. Further, we found METTL3 promoted CRC cell proliferation by methylating the m6A site in 3'-untranslated region (UTR) of CCNE1 mRNA to stabilize it. Moreover, we found butyrate, a classical intestinal microbial metabolite, could down-regulate the expression of METTL3 and related cyclin E1 to inhibit CRC development. METTL3 promotes CRC proliferation by stabilizing CCNE1 mRNA in an m6A-dependent manner, representing a promising therapeutic strategy for the treatment of CRC. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.In recent years, Lynn Margulis has been credited in various articles as the person who introduced the concept of holobiont into biology in the early 1990s. Today, the origin of evolutionary studies on holobionts is closely linked to her name. However, Margulis was not the first person to use this concept in its current context. That honor goes to the German theoretical biologist Adolf Meyer-Abich, who introduced the holobiont concept nearly 50 years before her (in 1943). Although nearly completely forgotten today, in the 1940-60s he developed a comprehensive theory of evolutionary change through "holobiosis." It had a surprisingly modern outlook, as it not only addressed tenets of today's evolutionary developmental biology (evo-devo), like the origin of form and production of variation, but also anticipated key elements of Margulis' later endosymbiotic theory. As the holobiont concept has become an important guiding concept for organizing research, labeling conferences, and publishing articles on host-microbiota collectives and hologenomes, the field should become aware of the independent origin of this concept in the context of holistic biology of the 1940s. © 2020 The Authors. Journal of Experimental Zoology Part B Molecular and Developmental Evolution published by Wiley Periodicals, Inc.BACKGROUND Administrative data provide a unique opportunity to examine whole-of-state colorectal cancer (CRC) data. The purpose of this study was to compare types of CRC resection across Victorian geographical zones, using hospital volume and accredited training-post status. METHODS All CRC resections in Victorian public hospitals between 2008 and 2013 were analysed using validated algorithms of administrative data from the Victorian Admitted Episodes Dataset. Hospitals were grouped according to Colorectal Surgical Society of Australia and New Zealand (CSSANZ) training-post status, case-volume (high >200 in 5 years) and remoteness of location. Resection frequency and type were compared. RESULTS In 44 public hospitals over 6 years, 7596 CRC resections were performed. Patient age, American Society of Anesthesiologists Physical Status Classification System score and tumour stage were similar among groups. CSSANZ accounted for nearly 50% of cases but the lowest percentage of emergencies (16.8%). The ratio of right-sided to left-sided plus rectal resections was greater for low-volume than high-volume centres (56.8% versus 40.4%), while left colon and rectal resections comprised a larger proportion of high-volume workload. High- compared with low-volume favoured ultra-low anterior resections (62% versus 33%) over abdominoperineal resections (38% versus 67%). Work patterns among high-volume hospitals were similar regardless of remoteness or CSSANZ status. CONCLUSION This study demonstrated that administrative data can provide granular, clinically relevant information with population-wide coverage. Most public CRC resections in Victoria were performed in metropolitan hospitals. The majority of rectal cancer resections were performed in high-volume metropolitan centres but 15% were performed by low-volume regional hospitals. © 2020 Royal Australasian College of Surgeons.OBJECTIVES Osteoarthritis (OA) and pain are both made more severe by low-grade inflammation. We examined whether visceral fat, a major source of inflammatory cytokines and adipokines, was associated with an increased risk of knee OA or of musculoskeletal pain. METHODS Member of the Multicenter Osteoarthritis Study cohort, age 50-79 with or at high risk of knee osteoarthritis had whole body DEXA scans at baseline. Epacadostat At baseline, 30, and 60 months they obtained knee radiographs and MRIs, were asked to score the severity of their knee pain and using a body homunculus, to identify sites of joint pain. We used DEXA scans to measure total body fat and in the torso, visceral fat and subcutaneous fat. We assessed the association of fat depot size with structural outcomes (incident radiographic OA, MRI cartilage loss and synovitis) and with pain outcomes (worsening knee pain, the number of painful joints and widespread pain). Regression analyses were adjusted for age, sex, race, education, smoking, physical activity, BMI and depressive symptoms. RESULTS At baseline, of 2,961 participants, 60.7% were women; mean age was 62.5 years and BMI 30.5 kg/m2 . After adjustment for covariates, no fat measures were associated with any structural outcomes. However, total and visceral but not subcutaneous fat were positively associated with worsening knee pain and widespread pain and the amount of visceral fat was associated with the number of painful joints. CONCLUSION Visceral fat was associated with an increased risk of musculoskeletal and widespread pain. This article is protected by copyright. All rights reserved.
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