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Utilization of place growth-promoting bacterias to boost salinity strain inside soy bean (Glycine max L.) crops.
Pharmacists agreed that the health authorities should take the lead for improving trust and confidence in the system for a better future in the era of genomics and pharmacogenomics.Human exposure to air pollution is a major public health concern. Environmental policymakers have been implementing various strategies to reduce exposure, including the 10th-day-no-driving system. To assess exposure of an entire population of a community in a highly polluted area, pollutant concentrations in microenvironments and population time-activity patterns are required. To date, population exposure to air pollutants has been assessed using air monitoring data from fixed atmospheric monitoring stations, atmospheric dispersion modeling, or spatial interpolation techniques for pollutant concentrations. This is coupled with census data, administrative registers, and data on the patterns of the time-based activities at the individual scale. Recent technologies such as sensors, the Internet of Things (IoT), communications technology, and artificial intelligence enable the accurate evaluation of air pollution exposure for a population in an environmental health context. In this study, the latest trends in published papers on the assessment of population exposure to air pollution were reviewed. Subsequently, this study proposes a methodology that will enable policymakers to develop an environmental health surveillance system that evaluates the distribution of air pollution exposure for a population within a target area and establish countermeasures based on advanced exposure assessment.We report the fatigue behavior of a novel multiscale fiberglass/epoxy composite modified with reduced-graphene oxide (rGO) and graphene nanoplatelets (GNP). A novel and cost-effective fabrication method based on vacuum assisted resin transfer molding (VARTM) method was used for manufacturing the composite laminates. Morphological and mechanical analysis of composites showed a successful dispersion of nano-fillers and a remarkable improvement in fatigue life of the nanocomposites. The experimental results revealed that all rGO concentrations resulted in a significant increase in fatigue life of the nanocomposites. These enhancements can be explained by the creation of stronger links between the nanoparticles fiberglass and epoxy. The experimental results also showed that lower concentrations of GNPs lead to an increase in fatigue life of nanocomposites; however, a decrease in their fatigue life can be seen at higher loadings.Hepatoblastoma is the most common childhood liver cancer. Although survival has improved significantly over the past few decades, there remains a group of children with aggressive disease who do not respond to current treatment regimens. There is a critical need for novel models to study aggressive hepatoblastoma as research to find new treatments is hampered by the small number of laboratory models of the disease. Organoids have emerged as robust models for many diseases, including cancer. We have generated and characterized a novel organoid model of aggressive hepatoblastoma directly from freshly resected patient tumors as a proof of concept for this approach. AZD9291 Hepatoblastoma tumor organoids recapitulate the key elements of patient tumors, including tumor architecture, mutational profile, gene expression patterns, and features of Wnt/β-catenin signaling that are hallmarks of hepatoblastoma pathophysiology. Tumor organoids were successfully used alongside non-tumor liver organoids from the same patient to perform a drug screen using twelve candidate compounds. One drug, JQ1, demonstrated increased destruction of liver organoids from hepatoblastoma tumor tissue relative to organoids from the adjacent non-tumor liver. Our findings suggest that hepatoblastoma organoids could be used for a variety of applications and have the potential to improve treatment options for the subset of hepatoblastoma patients who do not respond to existing treatments.
Wastewater treatment plants (WWTPs) are microbial factories aimed to reduce the amount of nutrients and pathogenic microorganisms in the treated wastewater before its discharge into the environment. We studied the impact of urban WWTP effluents on the abundance of antibiotic resistance genes (ARGs) and antibiotic-resistant
(AR-
) in the last stretch of two rivers (Arrone and Tiber) in Central Italy that differ in size and flow volume.

Water samples were collected in three seasons upstream and downstream of the WWTP, at the WWTP outlet, and at sea sites near the river mouth, and analyzed for the abundance of ARGs by qPCR and AR-
using cultivation followed by disk diffusion assays.

For all studied genes (
,
,
,
,
,
and
), absolute concentrations were significantly higher in the Tiber than in the Arrone at all sampling sites, despite their collection date, but the prevalence of target ARGs within bacterial communities in both rivers was similar. The absolute concentrations of most ARGs were also generally higher in the WWTP effluent with median levels between log 4 and log 6 copies per ml but did not show differences along the studied stretches of rivers. Statistically significant site effect was found for
phenotypic resistance to tetracycline and ciprofloxacin in the Arrone but not in the Tiber.

In both rivers, diffuse or point pollution sources other than the studied WWTP effluents may account for the observed resistance pattern, although the Arrone appears as more sensitive to the wastewater impact considering its lower flow volume.
In both rivers, diffuse or point pollution sources other than the studied WWTP effluents may account for the observed resistance pattern, although the Arrone appears as more sensitive to the wastewater impact considering its lower flow volume.Despite increasing research on the concept of addictive eating, there is currently no published evidence on the views of health professionals who potentially consult with patients presenting with addictive eating behaviours, or of students training to become health professionals. This study aimed to explore the views and understanding of addictive eating behaviours among health professionals and health professionals in training and to identify potential gaps in professional development training. An international online cross-sectional survey was conducted in February-April 2020. The survey (70 questions, 6 key areas) assessed participants' opinions and clinical experience of addictive eating; opinions on control, responsibility, and stigma relating to addictive eating; and knowledge of addictive eating and opinions on professional development training. In total, 142 health professionals and 33 health professionals in training completed the survey (mean age 38.1 ± 12.5 years, 65% from Australia/16% from the U.
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