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001, respectively), while endocrine had no change and gastrointestinal oncology had a slight increase (p = 0.823) in the number of cases performed.

The effects of the COVID-19 pandemic are wide-ranging within surgical oncology subspecialties. see more The addition of telehealth is a viable avenue for cancer patient care and should be considered in surgical oncology practice.
The effects of the COVID-19 pandemic are wide-ranging within surgical oncology subspecialties. The addition of telehealth is a viable avenue for cancer patient care and should be considered in surgical oncology practice.
Although impulsiveness has been recognized as a risk factor for suicide, few studies have explored how to protect offenders with impulsiveness from the risk of suicide. This study aims to examine the relationships among impulsiveness, suicide risk, regulatory emotional self-efficacy (RESE), and flourishing, focusing on the moderating effects of RESE and flourishing in the relationship between impulsiveness and suicide risk.

This is a cross-sectional study of 941 male offenders. All participants were requested to provide some items of demographic information and to complete a package of self-reported questionnaires measuring impulsiveness, suicide risk, RESE, and flourishing.

The results indicate that impulsiveness is positively correlated with suicide risk, while RESE and flourishing are negatively correlated with impulsiveness and suicide risk. Most importantly, both RESE and its dimension managing negative affect (NEG) negatively moderate the relationship between impulsiveness and suicide risk. Flourishing and the RESE dimension expressing positive affect (POS) show no significant moderating effect on impulsiveness-suicide risk link.

Regulatory emotional self-efficacy, especially its NEG dimension, can buffer the impact of impulsiveness on suicide risk in male offenders, indicating that these factors might be useful supplements in suicide prevention.

Offender with higher level of RESE and flourishing show lower level of impulsiveness and suicide risk. High level of RESE and its NEG dimension can buffer the effect of impulsiveness on suicide risk. RESE, especially its NEG dimension might be a useful supplement for suicide prevention in offenders with high impulsiveness.
Offender with higher level of RESE and flourishing show lower level of impulsiveness and suicide risk. High level of RESE and its NEG dimension can buffer the effect of impulsiveness on suicide risk. RESE, especially its NEG dimension might be a useful supplement for suicide prevention in offenders with high impulsiveness.
Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are increasingly well-characterized, but their impact on outcome and prognosis remain unknown.

This bi-institutional study of patients with confirmed iCCA (n=412) used targeted next-generation sequencing of primary tumors to define associations among genetic alterations, clinicopathological variables, and outcome. The most common oncogenic alterations were IDH1 (20%), ARID1A (20%), TP53 (17%), CDKN2A (15%), BAP1 (15%), FGFR2 (15%), PBRM1 (12%), and KRAS (10%). IDH1/2 mutations (mut) were mutually exclusive with FGFR2 fusions (fus), but neither was associated with outcome. For all patients, TP53 (p<0.0001), KRAS (p=0.0001), and CDKN2A (p<0.0001) alterations predicted worse overall survival (OS). These high-risk alterations were enriched in advanced disease but adversely impacted survival across all stages, even when controlling for known correlates of outcome (multifocal disease, lymph node involvement, bile duct type, periductal infiltratprognostic factors in iCCA when controlling for clinical and pathologic variables, disease stage, and treatment. Since genetic profiling can be integrated into pre-treatment therapeutic decision-making, combining clinical variables with targeted tumor sequencing may identify patient subgroups with poor outcome irrespective of treatment strategy.
TP53, KRAS, and CDKN2A alterations were independent prognostic factors in iCCA when controlling for clinical and pathologic variables, disease stage, and treatment. Since genetic profiling can be integrated into pre-treatment therapeutic decision-making, combining clinical variables with targeted tumor sequencing may identify patient subgroups with poor outcome irrespective of treatment strategy.
Systemic therapy (ST) can be deferred in patients who have metastatic renal cell carcinoma (mRCC) and slow-growing metastases. Currently, this subset of patients managed with active surveillance (AS) is not well described in the literature.

This was a prospective observational study of patients with mRCC across 46 US community and academic centers. The objective was to describe baseline characteristics and demographics of patients with mRCC initially managed by AS, reasons for AS, and patient outcomes. Descriptive statistics were used to characterize demographics, baseline characteristics, and patient-related outcomes. Wilcoxon 2-sample rank-sum tests and χ
tests were used to assess differences between ST and AS cohorts in continuous and categorical variables, respectively. Kaplan-Meier survival curves were used to assess survival.

Of 504 patients, mRCC was initially managed by AS (n = 143) or ST (n = 305); 56 patients were excluded from the analysis. Disease was present in 69% of patients who received AS, whereas the remaining 31% had no evidence of disease. At data cutoff, 72 of 143 patients (50%) in the AS cohort had not received ST. The median overall survival was not reached (95% CI, 122 months to not estimable) in patients who received AS versus 30 months (95% CI, 25-44 months) in those who received ST. Quality of life at baseline was significantly better in patients who were managed with AS versus ST.

AS occurs frequently (32%) in real-world clinical practice and appears to be a safe and appropriate alternative to immediate ST in selected patients.
AS occurs frequently (32%) in real-world clinical practice and appears to be a safe and appropriate alternative to immediate ST in selected patients.
To evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC).

Stathmin is a phosphoprotein involved in the regulation of microtubule dynamics and integration of intracellular signaling pathways. Stathmin has been implicated in the tumorigenesis of several cancers and is a potential therapeutic target.

Stathmin expression was evaluated in 25 metastatic CRC (mCRC) patients by immunohistochemistry (IHC). Ki67 IHC and TUNEL assay were also evaluated in mCRC for cell proliferation and apoptosis.

High expression of stathmin was correlated with CRC metastasis (p = .0084), and significantly worse overall survival (OS) in CRC patients (p = .036). There was a significant increase in cell proliferation and a decrease in apoptosis in liver metastasis compared with CRC primary tumors as determined by Ki67 IHC and TUNEL assay (p < .0001). We also observed a significant positive correlation between stathmin level and cell proliferation in both CRC primary tumor and liver metastasis (p = .
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