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Impact from the Belgian Seacoast about Well-Being Through the COVID-19 Pandemic.
98; and the Bland-Altman plots also revealed the validity of our method. Moreover, the concept of cervical motion curve was put forward to describe the movement track of neck in order to reflect the cervical health status. The proposed approach is feasible, automatic and convenient for the measurement of CROM and the generated cervical motion curve can intuitively exhibit the trajectory of neck. This technique that can easily acquire the biomedical information of cervical spine has tremendous potential in the diagnosis, healthcare and wellness management of neck.Studying the deep learning-based molecular representation has great significance on predicting molecular property, promoted the development of drug screening and new drug discovery, and improving human well-being for avoiding illnesses. It is essential to learn the characterization of drug for various downstream tasks, such as molecular property prediction. In particular, the 3D structure features of molecules play an important role in biochemical function and activity prediction. The 3D characteristics of molecules largely determine the properties of the drug and the binding characteristics of the target. However, most current methods merely rely on 1D or 2D properties while ignoring the 3D topological structure, thereby degrading the performance of molecular inferring. In this paper, we propose 3DMol-Net to enhance the molecular representation, considering both the topology and rotation invariance (RI) of the 3D molecular structure. Specifically, we construct a molecular graph with soft relations related to the spatial arrangement of the 3D coordinates to learn 3D topology of arbitrary graph structure and employ an adaptive graph convolutional network to predict molecular properties and biochemical activities. Comparing with current graph-based methods, 3DMol-Net demonstrates superior performance in terms of both regression and classification tasks. Further verification of RI and visualization also show better robustness and representation capacity of our model.Multi-modal magnetic resonance imaging (MRI) plays a critical role in clinical diagnosis and treatment nowadays. Each modality of MRI presents its own specific anatomical features which serve as complementary information to other modalities and can provide rich diagnostic information. However, due to the limitations of time consuming and expensive cost, some image sequences of patients may be lost or corrupted, posing an obstacle for accurate diagnosis. Although current multi-modal image synthesis approaches are able to alleviate the issues to some extent, they are still far short of fusing modalities effectively. In light of this, we propose a multi-scale gate mergence based generative adversarial network model, namely MGM-GAN, to synthesize one modality of MRI from others. Notably, we have multiple down-sampling branches corresponding to input modalities to specifically extract their unique features. In contrast to the generic multi-modal fusion approach of averaging or maximizing operations, we introduce a gate mergence (GM) mechanism to automatically learn the weights of different modalities across locations, enhancing the task-related information while suppressing the irrelative information. As such, the feature maps of all the input modalities at each down-sampling level, i.e., multi-scale levels, are integrated via GM module. In addition, both the adversarial loss and the pixel-wise loss, as well as gradient difference loss (GDL) are applied to train the network to produce the desired modality accurately. Extensive experiments demonstrate that the proposed method outperforms the state-of-the-art multi-modal image synthesis methods.Spiking neural networks (SNNs) contain more biologically realistic structures and biologically inspired learning principles than those in standard artificial neural networks (ANNs). SNNs are considered the third generation of ANNs, powerful on the robust computation with a low computational cost. The neurons in SNNs are nondifferential, containing decayed historical states and generating event-based spikes after their states reaching the firing threshold. These dynamic characteristics of SNNs make it difficult to be directly trained with the standard backpropagation (BP), which is also considered not biologically plausible. In this article, a biologically plausible reward propagation (BRP) algorithm is proposed and applied to the SNN architecture with both spiking-convolution (with both 1-D and 2-D convolutional kernels) and full-connection layers. Unlike the standard BP that propagates error signals from postsynaptic to presynaptic neurons layer by layer, the BRP propagates target labels instead of errors directly from the output layer to all prehidden layers. This effort is more consistent with the top-down reward-guiding learning in cortical columns of the neocortex. Synaptic modifications with only local gradient differences are induced with pseudo-BP that might also be replaced with the spike-timing-dependent plasticity (STDP). ETC-159 clinical trial The performance of the proposed BRP-SNN is further verified on the spatial (including MNIST and Cifar-10) and temporal (including TIDigits and DvsGesture) tasks, where the SNN using BRP has reached a similar accuracy compared to other state-of-the-art (SOTA) BP-based SNNs and saved 50% more computational cost than ANNs. We think that the introduction of biologically plausible learning rules to the training procedure of biologically realistic SNNs will give us more hints and inspiration toward a better understanding of the biological system's intelligent nature.This article presents a novel adaptive controller for a small-size unmanned helicopter using the reinforcement learning (RL) control methodology. The helicopter is subject to system uncertainties and unknown external disturbances. The dynamic unmodeling uncertainties of the system are estimated online by the actor network, and the tracking performance function is optimized via the critic network. The estimation error of the actor-critic network and the external unknown disturbances are compensated via the nonlinear robust component based on the sliding mode control method. The stability of the closed-loop system and the asymptotic convergence of the attitude tracking error are proved via the Lyapunov-based stability analysis. Finally, real-time experiments are performed on a helicopter control testbed. The experimental results show that the proposed controller achieves good control performance.
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