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Topological Studies of Protein-Ligand Binding: a Community Method.
Finally, the angles between the above-mentioned lines computed were analysed to check the parallelism. One sample t-test was utilized using SPSS. Results Mean angles value on right side of subjects between FxP to three reference points ATs, ATm, ATi were 3.261, 2.720 and 2.245 and on the left they were 2.347, 2.558 and 2.029 respectively showing no parallelism (angle value zero). Conclusions Major findings revealed no parallelism among these planes.Background Medicolegal data is very important for administrators, health officials, philanthropists, social workers, law enforcement agencies. Because it is used for planning and implementation of strategies in order to reduce further incidents. This study is conducted with the aim to determine different types of medicolegal cases and patterns of weapons used. Methods A total of 246 cases were studied from 1st September 2017 to 31st January 2018. All information was collected on a pro forma. Statistical analysis was done by MS Excel. Results Out of 246 cases, 219 were male and 27 were female with age ranging from 3 to 72 years. Among total, 162(65.85%) patients were injured due to blunt weapon, 17 (6.91%) cases of firearms, 23 (9.34%) in road traffic accidents, 15 (6.09%) sharp-edged weapons, 7 (2.84%) cases were of sexual violence, 11 (4.47%) were of poisoning. Conclusions Injuries of blunt weapons followed by sharp edge and accidental cases occurred more frequently.Background Commonest surgical emergency presenting to emergency departments with abdominal pain is acute appendicitis. Thus, to enable quick and accurate diagnosis of the condition various scoring systems have been developed. Among these, Alvarado and its modified version (Modified Alvarado) are the commonest. Whereas Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) score showed promising results in Asian population. Similarly, Lintula score, which was initially developed for paediatric population, has now been validated for elderly too. This study is aimed to compare these in our regional population. Methods Project included consecutive 125 clinically suspected acute appendicitis patients. All were scored using Modified Alvarado, RIPASA and Lintula systems. Final diagnosis was based on histopathologic evaluation of excised specimen. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were computed for all these systems by using SPSS statistical software and ROC curves were plotted. Results With cut-off of 7, Modified Alvarado was 62% specific, 83% sensitive and 65% accurate. While PPV and NPV were 94% and 33%, respectively. Whereas RIPASA yielded better results, i.e., sensitivity of 98.4%, specificity of 87%, PPV of 97%, NPV of 77% and diagnostic accuracy of 92%. Whereas Lintula showed sensitivity of 71%, specificity of 87%, PPV of 96%, NPV of 40 and accuracy of 73%. Conclusions RIPASA demonstrated higher sensitivity, PPV, NPV and diagnostic accuracy than Modified Alvarado and Lintula scores. Hence this study approves use of RIPASA score in the region. However further research on the subject is required to back this inference.Background This study is aimed to assess the efficacy of intralesional Bleomycin sclerotherapy in macrocystic lymphangioma in children. Methods This prospective observational study included 40 children diagnosed with macrocystic lymphangioma and treated with intralesional injection of Bleomycin from March 2016 to Dec 2018. We excluded all the patients above 12 years of age, lesions with size less than 2 cm, and post-surgical recurrent lesions. The response to the treatment was monitored clinically by assessing length, breadth and area of the lesion and ultrasonographically. Mean follow-up period was 2 years. Study variables were analysed by simple descriptive statistics. Mean and standard deviation were calculated for numerical variables (age). Frequency and percentage were calculated for gender, site, size and type of cystic lymphangioma and total number of treatment sessions. Results The mean age of patients was 3.51±2.98 years. Out of 40 patients, there were 26 (65%) male and 14 (35%) females with female to male ratio of 11.8. The commonest site and type of cystic lymphangioma was neck and macrocystic, i.e., 77.5% and 85% respectively. The pre and post procedure size of lesion was 9.71±3.95cm and 3.11±1.02 cm, respectively. Outcome was excellent in 20% patients, good in 72.5% and poor in 7.5% patients. read more Conclusions Intralesional Bleomycin sclerotherapy is effective in the treatment of macrocystic lymphangioma and is found to be harmless as there was no grave complication observed in this study.Background The clinical diagnosis of acute appendicitis remains difficult despite the use of different scoring systems. A high rate of negative appendectomies is no longer acceptable. This study was aimed to compare RIPASA score and Alvarado score in Pakistani population for the diagnosis of acute appendicitis using histopathology as a gold standard. Methods This crosssectional prospective study was carried out from January to September 2018 in the Accident and Emergency Department and Department of Surgery, Khyber Teaching Hospital, Peshawar. Patients clinically suspected as acute appendicitis aided by routine ultrasound were included in the study. RIPASA and Alvarado scoring were done in all patients. After appendectomies, specimen was sent for histopathological examination. A score of 7.5 was considered as optimal cutoff threshold for RIPASA and 7 for Alvarado score. Sensitivity, Specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and accuracies of both scores were calculated. Results A total of 300 patients were included in the study. The mean age of patients was 28±10.0 years and there were 176 males. Sensitivity, Specificity of RIPASA score and Alvarado score was found to be 98.52% and 90%, and 68.15% and 80% respectively. Positive Predictive Value and NPV of RIPASA score was 98.88% and 97.67% as compared to 96.84% and 21.82% for Alvarado score. Diagnostic accuracy of RIPASA and Alvarado score was 97.67% and 69.33% respectively.. Conclusions RIPASA scoring system is a more accurate, sensitive and specific indicator of diagnosing acute appendicitis as compared to Alvarado scoring system.
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