Notes

Large-Scale Temporary Manufacturing throughout ExpiCHO-S™ along with Improved N-Galactosylation-Sialylation as well as PEI-Based Transfection.
Although a rapid response system (RRS) can reduce the incidence of cardiopulmonary resuscitation (CPR) in general wards, avoidable CPR cases still occur. This study aimed to investigate the incidence and causes of avoidable CPR.

We retrospectively reviewed the medical records of all adult patients who received CPR between April 2013 and March 2016 (35 months) at a tertiary teaching hospital where a part-time RRS was introduced in October 2012. Four experts reviewed all of the CPR cases and determined whether each event was avoidable.

A total of 192 CPR cases were identified, and the incidence of CPR was 0.190 per 1,000 patient admissions. Of these, 56 (29.2%) were considered potentially avoidable, with the most common cause being doctor error (n=32, 57.1%), followed by delayed do-not-resuscitate (DNR) placement (n=12, 21.4%) and procedural complications (n=5, 8.9%). The percentage of avoidable CPR was significantly lower in the RRS operating time group than in the RRS non-operating time group (20.7% vs. 35.5%; P=0.026). Among 44 avoidable CPR events (excluding cases related to DNR issues), the rapid response team intervened in only three cases (6.8%), and most of the avoidable CPR cases (65.9%) occurred during the non-operating time.

A significant number of avoidable CPR events occurred with a well-functioning, part-time RRS in place. However, RRS operation does appear to lower the occurrence of avoidable CPR. Thus, it is necessary to extend RRS operation time and modify RRS activation criteria. Moreover, policy and cultural changes are needed prior to implementing a full-time RRS.
A significant number of avoidable CPR events occurred with a well-functioning, part-time RRS in place. However, RRS operation does appear to lower the occurrence of avoidable CPR. Thus, it is necessary to extend RRS operation time and modify RRS activation criteria. Moreover, policy and cultural changes are needed prior to implementing a full-time RRS.The poor water stability of metal-organic frameworks (MOFs) significantly hindered their catalytic application in advanced oxidation system. A protective outer layer was an effective strategy to solve this problem. However, the commonly used coating techniques are too complicated or too difficult to accurately control, thus, the applicability was relatively low. In this study, a water stable MOF core-SiO2 shell nanomaterial (Fe-MOF-74@SiO2) was synthesized by a facile hydrothermal method, and applied to activate persulfate (PS) for dimethyl phthalate (DMP) degradation. The catalyst water stability and DMP degradation in the system were investigated, suggesting that the SiO2-coated catalyst was more stable and exhibited higher DMP degradation efficiency over the pure MOF. It was found that pH had negligible effects on Fe-MOF-74@SiO2 + PS system, while, higher temperature facilitated the degradation of DMP. The activation mechanism was studied by quenching experiments combined with electron paramagnetic resonance, indicating that SO4⋅- played a major role in the activation of PS with Fe-MOF-74@SiO2 for DMP removal, while ⋅OH also involved in the catalytic process. Finally, possible DMP degradation pathways were proposed. These findings indicated that the core-shell structured Fe-MOF-74@SiO2 showed promise for DMP degradation by PS advanced oxidation system.Frequent oil-spill accidents not only cause serious and long-term damage to marine ecosystems, but also lead to a huge loss of valuable natural resources. To lighten the environmental pollution of oil spills as quickly as possible, an efficient and environment-friendly approach for oil-water separation is highly desirable. Herein, a facile one-pot room-temperature approach was developed for large-scale fabrication of covalent organic framework-coated superhydrophobic sponges (sponges@COFs). The as-prepared sponges@COFs possessed many superior properties, including superhydrophobicity with the water contact angle of approximately 154.3°, large specific surface area (153.059 m2/g), high porosity of the network structures, as well as good mechanical and chemical stability. Taking the aformentioned advantages together, the superhydrophobic sponges showed ultra-high adsorption capacity for oil and various organic solvents. In comparision with its own weight, the adsorption amount of the sponges@COFs for silicone oil was up to 150 times and for toluene was 125 times, respectively. Furthermore, the superhydrophobic sponges also showed fast and highly efficient oil-water separation, outstanding flame retardancy and recyclability. In addition, the sponges@COFs were successfully applied to the high-efficiency removal of oil suspension from industrial waste water, firmly confirming their application prospect in industrial wastewater treatment.Due to its enriched organic matter, nutrients and growth cofactors, as well as a diverse range of microorganisms, waste activated sludge (WAS) might be an ideal additive to stimulate organohalide respiration for in situ bioremediation of organohalide-contaminated sites. In this study, we investigated the biostimulation and bioaugmentation impacts of WAS-amendment on the performance and microbiome in tetrachloroethene (PCE) and polychlorinated biphenyls (PCBs) dechlorinating microcosms. Results demonstrated that WAS-amendment increased PCE- and PCBs-dechlorination rate as much as 6.06 and 10.67 folds, respectively. The presence of WAS provided a favorable growth niche for organohalide-respiring bacteria (OHRB), including redox mediation and generation of electron donors and carbon sources. Particularly for the PCE dechlorination, indigenous Geobacter and WAS-derived Dehalococcoides were identified to play key roles in PCE-to-dichloroethene (DCE) and DCE-to-ethene dechlorination, respectively. Similar biostimulation and bioaugmentation effects of WAS-amendment were observed on both PCE- and PCBs-dechlorination in three different soils, i.e., laterite, brown loam and paddy soil. Risk assessment suggested low potential ecological risk of WAS amendment in remediation of organohalide-contaminated soil. see more Overall, this study provided an economic and efficient strategy to stimulate the organohalide respiration-based bioremediation in field applications.
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