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Background Coronavirus primarily targets the human respiratory system, COVID-19 (Coronavirus disease 2019) triggered in China in the late 2019. In March 2020, WHO announced the COVID-19 pandemic. This study aims to analyze and visualize the scientific structure of the COVID-19 publications using co-citation and co-authorship. Methods This is a scientometric study. Web of Science Core Collection (WoSCC) was searched for all documents regarding COVID-19, MERS-Cov, and SARS-Cov from the beginning to 2020. An Excel spreadsheet was applied to gather and analyze the data and the CiteSpace was used to visualize and analyze the data. Results A total of 5159 records were retrieved in WoSCC. The structure of the network indicated that the network mean silhouette was low (0.1444), implying that the network clusters' identity is not identifiable with high confidence. The network modularity was 0.7309. The cluster analysis of the co-citation network on documents from 2003 to 2020 provided 188 clusters. The largest cluster entitled, "the Middle East respiratory syndrome coronavirus" had 255 nodes. The coauthorship network illustrated that the most prolific countries, USA, China, and Saudi Arabia, have focused on a specific field and have formed separate clusters. Conclusion The present study identified the important topics of research in the field of COVID-19 based on co-citation networks as well as the analysis of clusters of countries' collaborations. Despite the similarities in the production behavior in prolific countries, their thematic focus varies so that a country like China plays a role in "Quantitative Detection" cluster, while USA is the leading country in the "Biological Evaluation" cluster.Background The pathogenesis of Alzheimer's disease (AD) is believed to be occurred by the production of neurotic plaques of the beta-amyloid peptide (Aβ) and deposition of them. Therefore, biomarkers of abnormal Aβ processing may represent before the AD clinical biomarkers, which could be benefit for a successful disease management that may prevent the AD development. The aim of this study is to investigate of plasma Aβ40,42 levels in Alzheimer's patients in Syria and thus determine whether they may have a potential role as biomarker for identifying and predicting AD. Methods In this cross-sectional study, the plasma levels of Aβ1-40 and Aβ1-42 were investigated in two groups represent Syrian population, AD group; clinically diagnosed AD patients (n=50) and CN group; cognitively normal participants (n=33). This study first determined the reference interval of plasma Aβ1-40 and Aβ1-42 for cognitively normal Syrian. Results were analyzed using SPSS, 24, depending on independent-samples t test, considering that the value of p less then 0.05 is statistically significant. Results The results showed that the plasma levels of Aβ1-40 (p less then 0.001, OR=1.031, 95%CI 1.012-1.051) and Aβ1-42 (p less then 0.001, OR=1.306, 95%CI 1.145-1.490) were significantly higher in AD patients than in cognitively normal participants, and no significant association was shown between both of education and sex with plasma Aβ levels. Conclusion The plasma levels of Aβ1-40 and Aβ1-42 could be potential biomarkers for identifying and predicting AD.COVID-19 is a novel highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Immunosuppressed people are at a higher risk for unfavourable outcomes if infected with SARS-CoV-2, as cellular immunity plays a key role in determining the course and outcome in COVID-19. Kidney transplant recipients (KTRs) are thus a distinct subset of the population. We describe our early experience with 2 KTRs requiring hospital admission due to COVID-19 and who recovered well. We conclude that timely intervention in the form of modifying immunosuppression and close monitoring and institution of further measures based on clinical severity is needed in KTRs with COVID-19.Background Determining the factors affecting survival and appropriate treatment methods leads to improving the survival rate and quality of life in cancer patients; therefore this study was aimed to determine the effective factors on the survival rate of patients with Laryngeal cancer in Kerman city, Iran. Methods This retrospective cohort study included 370 patients with Laryngeal cancer who referred to the hospitals of Kerman city, Iran during 2008 to 2018. Data were analyzed using Cox Proportional Hazards and Lin-Ying's Additive Hazards models. Data analysis was done using SAS software version 9.4. The P-value of less than 0.05 was considered as statistically significant. Results The mean age at the time of diagnosis was 58.16±10.60 years. About 92% of the patients were men. The patient's 1, 3, 5, 7 and 10-years of overall survival rates were equal to 82.38%, 60.68%, 55.98%, 49.83%, and 30.91%, respectively. selleckchem Age at the diagnosis (p=0.001), radiotherapy (p=0.001), chemotherapy (p=0.015), surgery (p=0.031), and smoking (p=0.001) were found to have significant effect on the patient's survival rate in the Cox model. These variables were significant in the Lin-Ying model too. Conclusion Treatment is an important factor in controlling the disease and survival of cancer patients, and choosing the best treatment depends on the condition of the patient and the disease level.COVID-19 was first discovered in Wuhan, China, and has spread rapidly around the world. The most important manifestation of COVID-19 was ARDS-like lung injury at first, but the involvement of other organs, such as kidney, heart, liver, and skin, was gradually reported. It is important to report and share all atypical manifestations of this disease to help other physicians to gain more knowledge about this new viral disease. As mentioned, there are also studies that show different types of cutaneous involvement in these patients, but due to the lack of more detailed studies in this field, and on the other hand, the possible usefulness of skin lesions as a diagnostic or alarming sign in the COVID-19 era, in this study we report a COVID-19 patient with a large hemorrhagic blister similar to sepsis-induced skin lesion. Despite the lack of common symptoms of the disease, the lung scan of the patient was positive for COVID-19.
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