Notes

The function regarding MOZ/KAT6A within hematological malignancies as well as improvements in MOZ/KAT6A inhibitors.
Perceived Benefits and Risks A survey data set towards Wolbachia-infected Aedes Mosquitoes in the Klang Valley, Malaysia. Introduction The paper presents data collected using measures of perceived benefits, perceived risks, trust in key players, attitude towards nature versus material, attitude towards technology, religiosity, and attitude towards the Wolbachia-infected Aedes mosquitoes (WiAM) technique. The validated questionnaires were used to randomly survey targeted stakeholders in the Klang Valley, Malaysia, who had been asked to voluntarily participate in face-to-face interviews. Completed questionnaires were received from 399 respondents (adults above 18 years old) and comprised two stakeholder groups scientists (n = 202), and the public (n = 197). The detailed findings serve numerous opportunities to examine the social acceptance of Wolbachia-infected Aedes mosquitoes, to ensure the development of policy and action plans, and to encourage further study by other researchers interested in the measures and data presented.This dataset corresponds to a data series produced from automated data loggers during the MESOLAC experimental project. Nine pelagic mesocosms (about 3000 L, 3 m depth) were deployed in July 2019 in Lake Geneva near the shore of Thonon les Bains (France), simulating predicted climate scenarios (i.e. intense weather events) by applying a combination of forcing. The design consisted of three treatments each replicated three times a control treatment (named C - no treatment applied) and two different treatments simulating different intensities of weather events. The high intensity treatment (named H) aimed to reproduce short and intense weather events such as violent storms. It consisted of a short-term stress applied during the first week, with high pulse of dissolved organic carbon (5x increased concentration, i.e. total DOC ∼ 6 mg L-1), transmitted light reduced to 15% and water column manual mixing. The medium intensity treatment (named M) simulated less intense and more prolonged exposures such as during flsis aiming at generalising the effect of climate change on large lakes.This data article contains data on the Emiliania huxleyi abundance, phytoplankton composition, in the Barents Sea in summer 2014-2018, and physical and hydrochemical parameters in summer 2017. The data are based on the samples collected on stations, where E. huxleyi blooms were recorded. The physical data included the water temperature, salinity, oxygen concentrations at the surface, and various depths. Data of nutrients concentrations included followed parameters silicates, phosphates, nitrates, nitrites, ammonium, and dissolved inorganic nitrogen. The nutrients ratios are also given. Data of phytoplankton composition consists of the abundance of diatoms, dinoflagellates, coccolithophores, and small flagellates. The data presented in this article are associated with the research article entitled "Interannual variability of Emiliania huxlei blooms in the Barents Sea In Situ data 2014-2018" [1]. CM272 mouse The related research article examines the influence of abiotic factors such as temperature, salinity, nutrients concentrations, and biotic factors (phytoplankton composition) on E. huxleyi abundance.Despite the prevalence in the United States of miscarriage [1], stillbirth [2], and infant mortality associated with preterm birth and low birthweight [3], their causes remain largely unknown [4], [5], [6]. To advance the use of social media data as a complementary resource for epidemiology of adverse pregnancy outcomes, we present a data set of 6487 tweets that mention miscarriage, stillbirth, preterm birth or premature labor, low birthweight, neonatal intensive care, or fetal/infant loss in general. These tweets are a subset of 22,912 tweets retrieved by applying hand-written regular expressions to a database containing more than 400 million public tweets posted by more than 100,000 women who have announced their pregnancy on Twitter [7]. Two professional annotators labeled the 6487 tweets in a binary fashion, distinguishing those potentially reporting that the user has personally experienced the outcome ("outcome" tweets) from those that merely mention the outcome ("non-outcome" tweets). Inter-annotator agto advance the use of Twitter data for digital epidemiology of adverse pregnancy outcomes" [10].The use of transcriptomics data brings new insights and works as a powerful tool to explore the molecular mode of action (MoA) of transgenerational inheritance effects of contaminants of emerging concern. Therefore, in this dataset, we present the transcriptomic data of the transgenerational effects of environmentally relevant simvastatin levels, one of the most prescribed human pharmaceuticals, in the keystone amphipod species Gammarus locusta. In summary, G. locusta juveniles were maintained under simvastatin exposure up to adulthood (exposed group - F0E) and the offspring of F0E were transferred to control water for the three subsequent generations (transgenerational group - F1T, F2T and F3T). To gain insights into the biological functions and canonical pathways transgenerationally disrupted by simvastatin, a G. locusta de novo transcriptome assembly was produced and the transcriptomic profiles of three individual G. locusta females, per group, over the four generations (F0 to F3) - solvent control groups ver. The data furnished in this article allows a better molecular understanding of the transgenerational effects produced by simvastatin in the keystone amphipod G. locusta and has major implications for hazard and risk assessment of pharmaceuticals and other emerging contaminants. This article is related to the research article entitled "Transgenerational inheritance of chemical-induced signature a case study with simvastatin [1].Primary lateral sclerosis (PLS) is an adult-onset upper motor neuron disease manifesting in progressive spasticity and gradually resulting in considerably motor disability. In the absence of early disease-specific diagnostic indicators, the majority of patients with PLS face a circuitous diagnostic journey. Until the recent publication of consensus diagnostic criteria, 4-year symptom duration was required to establish the diagnosis. The new diagnostic criteria introduced the category of 'probable PLS' for patients with a symptom duration of 2-4 years. "Evolving diagnostic criteria in primary lateral sclerosis The clinical and radiological basis of "probable PLS" [1]. This dataset provides radiological metrics in a cohort of 'probable PLS' patients, 'definite PLS' patients and age-matched healthy controls. Region-of-interest radiological data include diffusivity metrics in the corticospinal tracts and corpus callosum as well as mean cortical thickness values in the pre- and para-central gyri in each hemisphere.
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