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Underwater soundscape description from cyclostationarity perspective.
These findings indicate that honeycomb-like gelatin scaffolds can promote the survival and chondrogenic differentiation of HUCMSCs to form hyaline-like cartilage. © 2020 Wiley Periodicals, Inc.To clarify the clinicopathological features of colorectal cancer in older people, systematic studies considering age, sex, and the tumor locus is needed. We focused on colon cancer in postmenopausal women ( less then 70 years, n = 68 vs. ≥70 years, n = 85), and examined the effect of age on clinicopathological features. Rates of medullary carcinoma /mucinous carcinoma were higher and pathological stages at diagnosis were less advanced in patients ≥70 years compared with less then 70 years. Matching pathological stages, no significant difference in disease-free interval was observed according to age; however, disease-specific survival (DSS) was poorer in patients ≥70 years than less then 70 years, being significantly different in stage IV cases. Regarding post-metastasis/recurrence (met/rec) cases, chemotherapy and surgery for metastasis were less frequent in those aged ≥70 years than less then 70 years. Post-met/rec DSS was poorer in ≥70 years, those with microsatellite instability, and those without surgery for met/rec than in each counterpart; however, post-met/rec chemotherapy exhibited no effect. Multivariate analyses revealed that an older age and no surgery for metastasis were independent predictors of disease-specific death. These findings remained after excluding stage IV cases. Older age was a potent risk factor of rapid disease-specific death after met/rec. © 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.A FLUENT software able to predict and assess the electrooxidation of ammonia from the simulation of ammonia concentration and flow field distribution was developed in this study. The flow field-based models of ammonia removal were simulated and modified through the experimental results. The parameter of reaction constant k is corrected to 0.00195, and the modified model fitted well with experimental values, with the error less than 4%. The electrode depth of 4 cm was assessed to be optimal for ammonia removal based on the comparison of the simulation results on ammonia concentration and flow field distribution. The prediction result applied in the industrial wastewater treatment indicated that complete ammonia could be achieved at 0.27 Ah/L, and about 50% of total nitrogen was removed at 0.8 Ah/L. About 7% of chloride ions are converted into inorganic by-products, indicating low biological toxicity and risk on environment. The energy consumption increased with the promotion of removal efficiency of total nitrogen, requiring 5.4 kWh/m3 to remove 50% total nitrogen at 0.8Ah/L. The results show the practicability and feasibility of this FLUENT software tool on the simulation and prediction of electrooxidation process, which can provide the simulation parameter settings for the subsequent application. This article is protected by copyright. All rights reserved.AIMS β-cell function declines over time in type 2 diabetes (T2D), thus efficacy of iGlarLixi by C-peptide levels and duration of diabetes was evaluated in an exploratory analysis of the LixiLan-G study. METHODS LixiLan-G was a 26-week, randomized, open-label study in adults with T2D inadequately controlled while on glucagon-like peptide 1 receptor agonist (GLP-1 RA), with metformin, with/without pioglitazone and/or a sodium-glucose cotransporter 2 inhibitor. This analysis investigated the efficacy of switching to iGlarLixi by fasting baseline quartile C-peptide levels and baseline quartile of duration of T2D compared with continued GLP-1 RA use. RESULTS Change in glycated hemoglobin (HbA1c) from baseline to week 26 was significantly greater with iGlarLixi compared with continued GLP-1 RAs across all fasting C-peptide quartiles (-1.00% to -1.06% range vs. -0.23% to -0.54% range, respectively) and irrespective of all T2D duration quartiles (-0.94% to -1.07% vs. -0.25% to -0.50% range). A significantly greater proportion of participants in the iGlarLixi arm achieved an HbA1c of less then 7% across all C-peptide quartiles (51%-73% range) than in the GLP-1 RA arm (19%-32% range). The greatest reductions in HbA1c in participants receiving iGlarLixi were observed in those with the shortest duration of disease, though consistently greater than reductions observed with continued GLP-1 RAs. Reductions in HbA1c were comparable across C-peptide quartiles within the iGlarLixi arm. CONCLUSIONS The results of this study suggest that iGlarLixi is an effective treatment option, irrespective of C-peptide levels or duration of diabetes, in adults with insufficiently controlled T2D receiving GLP-1 RAs. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.BACKGROUND Beard and mustache are important components of body image. Beard transplantation is the procedure to restore congenital absence or inefficient growth of beard and mustache. OBJECTIVES The aim of the study is to report our results and experience in beard transplantation. METHODS Patients with a demand for beard restoration who were treated with follicular unit extraction (FUE) hair transplantation method were included in this retrospective, case series study. https://www.selleckchem.com/products/cbr-470-1.html Patients' birth date, race, presence of eunuchoidism, hair color, type and shaft thickness, and treatment details were retrieved from medical records. Patients were evaluated at least one year after the operation, and defect closure rates were calculated. At the follow-up examination, patients were asked to evaluate their satisfaction from the procedure. RESULTS Ten patients were consecutively treated between May 2007 and June 2016. The mean age of the patients was 29.6 years. Three of our patients were eunuchoid and the others wanted beard transplantation to have a more masculine look. Follow-up period was median of 39 months. Four patients were satisfied and four patients were very satisfied with the procedure with a mean 53% closure rate. Better closure rates were associated with brown and red hair color, medium and fine hair thickness, and absence of eunuchoidism. Patients with straight hair were satisfied with the procedure significantly. CONCLUSION Beard reconstruction by using the FUE method is a safe and effective method with high patient satisfaction rates. © 2020 Wiley Periodicals, Inc.
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