Notes

Age-associated changes in microglia and astrocytes improve blood-brain obstacle disorder.
They emphasize the technical difficulties to efficiently reduce all the nasal dimensions, the importance of the soft tissues quality, as they cover the nasal cartilaginous framework, and the absolute necessity of biological normalization to provide a stable and satisfactory result.Femoral neck fracture (FNF) is not common in osteogenesis imperfecta patients but may result in serious complications if not properly treated in due time. We present three types of FNF in osteogenesis imperfecta and their characteristics, treatment methods and outcomes. Cases of FNF followed for more than 2 years were selected from the osteogenesis imperfecta database. Medical records and radiographs were reviewed to obtain demographic information and to determine ambulatory status, mode of injury, location of the fracture line, presence of preexisting implants, treatment methods and complications. Outcomes were evaluated according to the radiographic results and ambulatory function. The study investigated 15 FNFs in 10 patients including 1 Sillence type I, 1 type III and 8 type IV. They were either community or household ambulators. The mean age at fracture was 11.7 years. The fractures were followed for an average of 6.3 years. Six fractures were attributed to accidental injuries and nine without noticeable trauma. The fracture pattern was categorized into undisplaced (n = 3), angulated-stable (n = 7) or displaced-unstable (n = 5) types. Five fractures were fixed in-situ using screws or Kirschner wires. Other five fractures were treated by closed reduction and screw fixation and the remaining five fractures were managed by femoral valgus osteotomy. Bony union was achieved, and prefracture ambulatory status was restored in all cases. A high index of suspicion is required in the diagnosis of undisplaced or angulated-stable fractures. Treatment is usually challenging, but a judicious approach considering the fracture pattern and patient characteristics result in successful outcomes. The angulated-stable pattern of fracture is unique in osteogenesis imperfecta patients and requires special attention.Pediatric forearm and wrist fractures are common; furthermore, some are displaced and require manipulation and reduction. The procedure is commonly performed without real-time image guidance and evaluated radiographically after reduction and casting, leading to multiple reduction attempts and malalignment. Although fluoroscopy can provide real-time assessment of fracture alignment during the procedure, it is not readily available in many emergency departments (EDs) and involves radiation exposure. Ultrasonography is an alternative real-time imaging modality that is inexpensive and readily available. The purpose of this study was to determine whether the use of real-time bedside sonography during closed reduction of distal and middle third forearm fractures can decrease the number of reduction attempts and reduce the number of patients requiring surgery. We compared the results of a conventional blind manipulation, fracture reduction, and casting to fracture reduction under real-time ultrasonographic guidance, in patients treated in our ED between 2014 and 2016. MC3 Overall, 458 patients with distal or middle third fractures were included. Of these reductions, 289 were performed without real-time imaging (group 1) and 169 under real-time ultrasound guidance (group 2). In group 1, 10% of patients required re-reduction, and 5% of patients needed surgery. In group 2, only one patient (0.6%) required re-reduction and 1% of patients required surgery due to fracture instability. In conclusion, the current study shows that real-time ultrasound-guided forearm fracture reduction is an effective and inexpensive method for correction of displaced forearm and wrist fractures in children, which does not involve any radiation exposure.
To investigate the subchondral bone surface of the distal femoral epiphysis and monitor the morphologic changes on ultrasonography (US) in growing children.

A total of 160 football players aged 9-11 years underwent ultrasonographic examination of both knees. The regularity of the subchondral bone surface of the femoral condyles was classified as grade 0 (smooth), 1 (focal semilunar depression or indentation) or 2 (broad irregularity). The relationship between age and frequency of irregularity was analyzed. Children with a grade 2 were referred for radiography and MRI to check for osteochondritis dissecans (OCD). All players underwent repeat examination 1 year later.

On initial examination, 82/320 knees (25.6%) were categorized as grade 0, 237/320 (74.1%) as grade 1 and 1 (0.3%) as grade 2. Logistic regression analysis revealed a significant association of increasing age with decreased irregularity of subchondral bone in the lateral and medial condyles (P = 0.019 and P < 0.001 for trend, respectively)distal femoral epiphysis and could be a useful screening tool for detecting OCD.
The most common treatment method for a fixed knee flexion contracture more than 10 degrees in cerebral palsy (CP) is distal femoral extension osteotomy (DFEO). However, a serious complication after a DFEO is neurological impairment. Its rates were reported as 5- 40%. Intraoperative neuromonitoring (IONM), widely used in spinal surgery and in other fields, is a valuable tool to define any neurological injury during operation. The aim of our study was to determine surgical steps with risk of neurological injury and to report if precautions would be effective in recovering signal loss.

We performed IONM during DFEO of 23 knees of 12 children with CP. IONM was performed by recording somatosensory evoked potentials, transcranial motor evoked potentials and free-run electromyography during defined steps throughout the surgery. Preoperative and postoperative popliteal angles, flexion contractures and physeal posterior distal femoral angles were evaluated.

We detected alert signals at osteotomy or manipulation steps of surgeries of all patients. We observed persistent alert signals in two cases (2 out of 23 knees; Group 2). In this group, the action potentials recovered only after 5 and 10 degrees of undercorrection at the osteotomy sites. Alert signals disappeared after a brief period of waiting in other cases. Throughout mean 37 months of follow-up, none of our patients experienced any neurological complication.

The study concludes that the surgical steps in DFEO with a higher risk for a neurological complication were the osteotomy and manipulation steps. Alert signals were detected with the help of IONM, and preventive measures were effective in recovering neuromonitoring recordings.
The study concludes that the surgical steps in DFEO with a higher risk for a neurological complication were the osteotomy and manipulation steps. Alert signals were detected with the help of IONM, and preventive measures were effective in recovering neuromonitoring recordings.
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