Notes

Aspects Impacting on the quality of Incapacity within Individuals With Multiple Sclerosis.
This paper offers an informed commentary on the actual and potential impacts of the pandemic on financial markets, sector and centres, grounded in literature on financial centres, the state-finance nexus, and trends affecting the landscape of finance since the global financial crisis. We expect a slowdown in new financial regulation, continued firm-level consolidation, and a continued rise of business services related to finance. The application of new financial technologies is likely to accelerate, affecting retail banking in particular, but will not necessarily be led by FinTech firms. Local and regional financial centres are likely to face larger challenges than leading international centres. As the panic and partial recovery in financial markets in March and April 2020 highlighted the significance of the international monetary hierarchy, with the US$ in the lead, a radical shift of financial power to Asia seems unlikely.This paper looks at the particular geographies associated with the COVID-19 outbreak through the lens of cities that are products of relational urbanisation. This includes small but highly globalised cities, such as financial centres or hot spots of politics and diplomacy, which are usually situated between different political, economic or cultural systems and their boundaries. These cities experienced strong growth due to internationalisation and a dedicated politics of extraversion. Our argument is that such places are unusually affected by the current lock-down, illustrated by two empirical cases, the cities of Dublin, Ireland, and Luxembourg City, Luxembourg. Both have experienced striking growth rates recently, but now suffer from disruption. Their development trajectories remain unclear, since a return to the 'old normal' seems unlikely, and the emergent 'new normal' calls for adaptation towards more state involvement in areas hitherto governed by the market. The paper addresses possible alternative geographies for both cases.This paper offers an insight into the role of young people in shifting risk perception of the current global pandemic, COVID-19, via social distancing narratives on social media. Young people are creatively and affectively supporting the social distancing initiatives in Brunei Darussalam through the use of social media platforms such as Instagram, Twitter, and Tik Tok. Using qualitative content analysis (QCA) data of social media content by Bruneian youth, this paper reveals the localised and contextualised creative production of five 'social distancing' narratives as a response to the national and global concerns in times of a global pandemic narrative of fear; narrative of responsibility; narrative of annoyance; narrative of fun; and narrative of resistance. This paper reflects on three key socio-cultural reconfigurations that have broader implications beyond the COVID-19 crisis new youth spatialities and social engagements; youth leadership in development; and consideration of social participation and reach in risk communication.This critical commentary reflects on a rapidly mobilised international podcast project, in which 25 urban scholars from around the world provided audio recordings about their cities during COVID-19. New digital tools are increasing the speeds, formats and breadth of the research and communication mediums available to researchers. Voice recorders on mobile phones and digital audio editing on laptops allows researchers to collaborate in new ways, and this podcast project pushed at the boundaries of what a research method and community might be. Many of those who provided short audio 'reports from the field' recorded on their mobile phones were struggling to make sense of their experience in their city during COVID-19. The substantive sections of this commentary discuss the digital methodology opportunities that podcasting affords geographical scholarship. In this case the methodology includes the curated production of the podcast and critical reflection on the podcast process through collaborative writing. Then putting this methodology into action some limited reflections on cities under COVID-19 lockdown and social distancing initiatives around the world are provided to demonstrate the utility and limitations of this method.The term 'crisis' is omnipresent. The current corona virus pandemic is perceived as the most recent example. However, the notion of crisis is increasingly deployed as a signifier of relevance, rather than as an analytical concept. Moreover, human geography has so far little contributed to the interdisciplinary crisis research field which is fixated on the temporal aspects of crisis but neglects its spatiality. Against this background, the first aim of the paper is to demonstrate the value of thinking about crisis analytically. Therefore, we introduce theoretical knowledge developed within a recently emerging literature on crisis management. Second, we demonstrate the relevance of including geographical thinking into crisis research more systematically. Based on the TPSN-framework by Jessop et al., we illustrate spatial dimensions of the 'corona crisis', its perception and handling in Germany. The empirical references are based on media reports.The Michael addition step and the following C5 isomerization in Hayashi's synthesis of Oseltamivir was studied by means of a DFT mechanistic study. These steps are crucial for the viability of the process where the formation of a single stereoisomer is required. The results indicate that the addition reaction is under thermodynamic and not kinetic control and that the key factor determining the reaction stereoselectivity are the stereochemical constraints imposed by all substituents in the cyclohexane ring. selleckchem The DFT results indicate that cyclohexylthiol should behave similarly to p-toluylthiol, the one actually employed, and tert-butylthiol should increase the ratio between isomers favoring the desired S configuration of the C5 atom. This work shows that DFT studies can be useful in the selection of a reactant to improve stereoselectivity of a chemical step.We employ multifractal detrended fluctuation analysis (MF-DFA) to provide a first look at the efficiency of forex markets during the initial period of the ongoing coronavirus disease 2019 (COVID-19), which has disrupted the global financial markets. We use high-frequency (5-min interval) data of six major currencies traded in forex markets during the period October 1, 2019 to 31 March 31, 2020. Before applying MF-DFA, we examine the inner dynamics of multifractality through seasonal and trend decompositions using loess. Overall, the results confirm the presence of multifractality in forex markets, which demonstrates, in particular, (i) a decline in the efficiency of forex markets during the COVID-19 outbreak and (ii) heterogeneous effects on the strength of multifractality of exchange rate returns under investigation. The largest effect is observed for the Australian dollar, which shows the highest (lowest) efficiency before (during) the COVID-19 pandemic, assessed in terms of low (high) multifractality. The Canadian dollar and the Swiss Franc exhibit the highest efficiency during the COVID-19 outbreak.
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