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Will non-surgical pancreaticoduodenectomy improve the probability of the publication oncologic outcome?
The aim of the study was to assess general characteristics of drug resistant tuberculosis and its association with treatment outcomes in Georgia. A retrospective cohort study was conducted among 1581 DR-TB adult (18+) patients, from 2015 - 2020 cohorts, whose anti-tuberculosis treatment outcomes was known. Adjusted analysis of the study participants data [1581 (100%)] shows significant association of a successful TB treatment outcome with the "Female gender" (adjusted OR 1.78, 95% CI 1.33 - 2.39, p less then 0.001), "New TB case" (adjusted OR 2.34, 95% CI 1.88-2.91, p less then 0.001) and with "HIV negative status" (OR 2.33; 95% CI 1.53-3.55; p less then 0.001). Based on bivariate and multivariate analysis of the study data, the significant association of a treatment outcome with other key factors, including "New drugs in the regimen" was not found. Since the programmatic using of the new effective DR-TB regimens are widely recommended only from 2019, the treatment outcomes of all patients on these regimens are still not defined. Further studies are necessary to assess complete data of the patients on new DR-TB regimens and its association with the treatment outcomes.The aim of this study was to investigate the features of bone metabolism and their influence on the arterial wall stiffness in postmenopausal women with a controlled uncomplicated arterial hypertension (AH). The study involved 44 women (main group) with the mean age of 69.04±0.72 years and a postmenopausal duration of 18.4±0.85 years, suffering from an AH grade 2, and 30 healthy patients (control group), their mean age being 69.3±1.21 years, postmenopausal duration 19.4±1.18 years (p>0.05). All patients underwent general clinical and laboratory examination with determination of lipid level in blood. Pulse wave analysis (SphygmoCor) parameters , Bone mineral density (BMD) were assessed. The levels of 25(OH) D, parathyroid hormone, propeptide procollagen of type 1 aminoterminal (P1NP), b-isomerized C-terminal telopeptides (b-CTx), ionized calcium and phosphorus in serum were assessed. The data obtained from the study of the parameters of applanation tonometry and the structural and functional state of bone tissue in patients with an uncomplicated hypertension at the age of 69±3.30 years manifest the likelihood of joint pathogenetic mechanisms of developing atherocalcinosis, increased vascular stiffness and impending osteoporosis.The recent data have shown that in addition to biological and psychosocial mechanisms, individual pain perception can be altered by satiety level as well. Some studies confirm that there is a relationship between being fed by sucrose and hyperalgesia in animals, while others show that ketogenic diet can be associated with decreased pain sensitivity to thermal stimuli. It can be argued that the effect of satiety level on pain perception is mediated by gastrointestinal hormones and endogenous opioids. Pharmacological stimulation of kappa-opioid receptors decreases stress and promotes analgesia. Accordingly, these changes can be inhibited by applying antagonists. Our study aims to assess pain perception induced by mechanical experimental irritation in women during different satiety levels in follicular phase of ovarian-menstrual cycle. The sample of the study was comprised of volunteer students aged 18-23 (women, mean age 19,5±2,9). Ovarian-menstrual cycle of the women participating in the research were evaluatethat is followed by activation of several humoral factors and duodenal afferentation. In addition, by some authors duodenal release of cholecystokinin is believed to be hypothetical cause of decreased pain sensitivity after 20-30 minutes from the last mixed meal and is thought to have antinociceptive effect on endogenous opioid system.The aim of our study was to identify the relationship between TGF-β1, arterial stiffness, and target organ damage in patients with uncontrolled arterial hypertension (UAH). The study included 140 patients with hypertension 30 people with uncontrolled hypertension (UAH), 80 people with controlled hypertension (CAH) and 30 people in the control group. check details All patients underwent determination of arterial stiffness using cardio-ankle vascular index (CAVI) and TGF-β1 level. The TGF-β1 level was 19,2 [17,2; 24,7] ng/ml in the CAH group. In the UAH group - 22,6 [20,6; 25,6] ng/ml. In the control group - 17.4 [11,8; 19,3] ng/ml. The maximum and minimum values of the CAVI indices were observed in the group UAH 9,2 [8,5; 9,9] and control group 7 [6,5; 7,5], respectively (p less then 0,05), in the CAH group there was an intermediate value of the CAVI index 7.8 [7,0; 8,5] (p less then 0,05). The correlation analysis revealed a significant relationship between the TGF-β1 level and CAVI for patients with hypertension (CAG r=0,777; NAG r=0,753; p less then 0.05). There was a significant difference in the TGF-β1 levels depending on the stage of hypertension in patients CAH (p less then 0,05). According to the results of the one-way regression analysis, it was revealed that in hypertensive patients with a TGF-β1 value, the most significant interactions are between myocardial mass (MM) (p less then 0,05), CAVI (p less then 0,05) and creatinine (p less then 0,05). An increase in the concentration of TGF-β1 and an increase of arterial stiffness were revealed in patients of the UAH group in comparison with the other groups. The relationship between TGF-β1 and arterial stiffness was also found.The aim of the study was to identify the features of coronary lesions and to determine the correlation between the main risk factors for coronary artery disease according to the SCORE quality of life scale and the calcium index in MSCT in different age and ethnic groups in men and women living in Kazakhstan. We retrospectively analyzed 935 case histories of patients undergoing MSCT to assess the condition of the coronary arteries. The patients were divided into three groups Kazakhs (66.9%), Russians (21.4%) and other (11.7%) nationalities. There were statistically significant differences between ethnic groups in BMI (p=0.03), type of chest pain (p less then 0.01), statin use (p=0.01), and blood glucose (p less then 0.01). The study showed that the prevalence of coronary atherosclerosis is higher among Russians compared to Kazakhs, even after adjusting for traditional risk factors. In multivariate analysis, the calcium index values were significantly higher in the group of the Russian population by 48% (OR=1.48; 95% CI 0.
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