Notes

To prevent tweezers beyond refractive list mismatch making use of highly doped upconversion nanoparticles.
The French colorectal cancer screening program is based on a fecal immunochemical test, followed by colonoscopy in case of positivity. The benefit of adding a concomitant upper endoscopy to detect upper digestive lesions (precancerous or others) is still debated. Our aim was to evaluate the frequency of upper digestive lesions detected by upper endoscopy performed concomitantly with colonoscopy following a positive fecal immunochemical test, and their impact on the patients' management (i.e., surveillance, medical treatment, endoscopic or surgical procedure).

Data of all the patients who consulted for a positive test between May 2016 and May 2019 in our center, and for whom concomitant upper endoscopy and colonoscopy were performed, were analyzed retrospectively. Patients with significant history of upper gastrointestinal diseases or with current gastrointestinal symptoms were excluded.

One hundred patients were included [median age (min-max) 62 (50-75), men 64%]. Macroscopic and/or microscopic upper diing in France. Further studies are necessary to confirm these results and to evaluate cost-effectiveness of this approach.
The aim of this study was to examine the effect of hand massage and foot massage on fatigue in hemodialysis patients.

This randomized, controlled and quasi-experimental study was conducted between October 19, 2018 and February 11, 2019 with patients receiving hemodialysis therapy in the dialysis unit of a public hospital in Turkey. Data were collected using a Patient Identification Form and the Visual Analogue Scale for Fatigue. The study was carried out with 82 patients in three groups a hand massage group (n=27), a foot massage group (n=27) and a control group (n=28). The patients in the control group were not administered any treatments except for standard nursing interventions in the hemodialysis unit.

In between-groups comparison the hand and foot massage groups' mean fatigue score decreased after the application compared to that of the control group (p<0.05).

Hand and foot massage were found to reduce fatigue in patients receiving hemodialysis.
Hand and foot massage were found to reduce fatigue in patients receiving hemodialysis.
Limitations of traditional medicine and rising interest in complementary medicine call for a closer look at the potential relevance of manual medicine, specifically osteopathic manipulative treatment (OMT) in children.

To conduct a retrospective observational pilot study of babies who received OMT in the newborn nursery compared to those who did not, by quantifying their outpatient health issues in the first 6 months of life, and to determine the feasibility of further definitive randomized controlled trials of a similar nature.

Retrospective chart review of the first 6 months of life from pediatric clinic records of 58 case-matched pairs of children, half of whom received OMT as part of their routine newborn care by virtue of their physician "call" assignment to the author. The sample from which the case-matched control group was chosen were babies who had received routine allopathic newborn care without OMT. Both groups received their pediatric care in the same academic ambulatory clinic and received d to GI complaints and irritability. Other studies would benefit from a variety of methodologic changes, including correlation of timing of administration of OMT with possible symptoms and changes in those symptoms over longer periods of observation, as well as correlation of anatomic osteopathic findings with specific symptoms.
Findings point to the need for further research in this area based on the suggestion that OMT given to a newborn can positively affect that baby's short-term and quite possibly long-term health, specifically related to GI complaints and irritability. Other studies would benefit from a variety of methodologic changes, including correlation of timing of administration of OMT with possible symptoms and changes in those symptoms over longer periods of observation, as well as correlation of anatomic osteopathic findings with specific symptoms.Inflammation is considered a major contributor to non-alcoholic fatty liver disease (NAFLD) and several chronic diseases such as, cardiovascular disease and type two diabetes. Green coffee bean extract (GCBE) supplementation has been suggested to enhancing antioxidant capacity in people with obesity but results across studies are mixed. We conducted a meta-analysis of randomized controlled trials of GCBE supplementation in overweight/obese with normal liver function and NAFLD adults with ALT, AST, γ-GTP, ALP, LDH, CRP, IL-6, and TNF-α as outcomes by searching PubMed and other databases. Eight studies were included, totaling 330 participants randomized to GCBE supplementation or placebo ranging from 50 mg/day to 1200 mg/day for 8-12 weeks. GCBE supplementation resulted in lower levels of TNF-α (mean difference = 1.37 pg/mL [95% CI = 0.97-1.76]; p less then 0.00001). No significant difference was found in the remaining markers. In conclusion, GCBE supplementation attenuated TNF-α, a circulating inflammatory marker mediator which may be linked with lower systemic inflammation. However, potential cellular and molecular mechanisms by which GCBE exerts this positive effect warrants further investigations in human model studies.
The ACTS-CC 02 trial demonstrated that S-1 plus oxaliplatin (SOX) was not superior to tegafur-uracil and leucovorin (UFT/LV) in terms of disease-free survival (DFS) as adjuvant chemotherapy for high-risk stage III colon cancer (any T, N2, or positive nodes around the origin of the feeding arteries). Androgen Receptor Antagonist datasheet We now report the final overall survival (OS) and subgroup analysis according to the pathological stage (TNM 7th edition) for treatment efficacy.

Patients who underwent curative resection for pathologically confirmed high-risk stage III colon cancer were randomly assigned to receive either UFT/LV (300 mg/m
of UFT and 75 mg/day of LV on days 1-28, every 35 days, five cycles) or SOX (100 mg/m
of oxaliplatin on day 1 and 80 mg/m
/day of S-1 on days 1-14, every 21 days, eight cycles). The primary endpoint was DFS and the patients' data were updated in February2020.

A total of 478 patients in the UFT/LV group and 477 patients in the SOX group were included in the final analysis. With a median follow-up time of 74.
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