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Story thienopyrimidine analogues because potential metabotropic glutamate receptors inhibitors as well as anticancer exercise: Activity, In-vitro, In-silico, along with SAR methods.
We propose a two-stage process to achieve successful resolution of termination ruptures (a) identification of termination ruptures and (b) addressing and resolving termination ruptures. For each stage, we propose practice-based guidelines and steps to follow. We demonstrate the proposed guidelines based on the case study of a patient with major depressive disorder. We used three sources of information from the case study verbal transcripts of the therapy sessions, questionnaires, and semistructured posttreatment interviews. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Methamphetamine (MA) is a highly addictive stimulant with recent upward trends in prevalence and associated public health problems. Drug demand, as assessed by hypothetical purchasing tasks, has been useful in addictions research and may help our understanding of the factors influencing MA use. However, no studies have assessed MA demand using current models of demand. The purpose of the current study was to assess demand for MA using a hypothetical drug purchasing task. Given high rates of cigarette smoking among MA users, it was of interest also to assess and compare demand for MA relative to cigarettes. Participants consisted of non-treatment-seeking volunteers with MA use disorder (N = 18), of whom 17 reported daily smoking. Results showed the exponentiated demand model provided a good fit to consumption data. Results from Bayesian generalized linear modeling demonstrated multiple positive relationships (posterior probability ≥75%) between self-reported drug use (days MA used in the past 30 days, cigarettes smoked per day) and indices of demand for each drug (Qo, Omax, Pmax, and break point). Comparing MA to cigarettes, results from Bayesian generalized linear mixed modeling revealed greater abuse liability for MA compared to cigarettes (posterior probability ≥99%) based on α and essential value. selleck products Overall, the findings of the current study support the feasibility and validity of the exponentiated demand model for assessing demand for drugs among individuals with MA use disorder. (PsycInfo Database Record (c) 2020 APA, all rights reserved).OBJECTIVE Familism, a cultural value that emphasizes strong family connectedness, has been associated with warm parenting behaviors among fathers and may moderate the effects of stress on parenting. However, few studies have examined familism as a protective factor against household and neighborhood risks. This study examined (a) the relations of poor living conditions and neighborhood disorder to paternal warmth and rejection and (b) familism as a moderator of relations between poor living conditions, neighborhood disorder, and paternal warmth and rejection. METHOD Low-income urban Filipino fathers (N = 84, Mage = 44.85, SD = 8.89) completed orally administered questionnaires. Hierarchical regression analyses were used to examine associations between poor living conditions, neighborhood disorder, familism, warmth, and rejection. RESULTS Poor living conditions, measured as a composite risk index of housing status, water supply, access to electricity, and food insecurity, were significantly associated with lower levels of warmth. Neighborhood disorder was also significantly associated with greater rejection. Familism was significantly associated with greater warmth, indicating its promotive role in fathers' parenting. Moderation analyses indicate that higher familism was associated with less rejection only at lower levels of risk in living conditions. At higher levels of risk, the association of familism with rejection was nonsignificant. CONCLUSIONS The protective function of familism in parenting may have limits at high levels of risk. Interventions for low-income Filipino fathers may need to address reduction of household and neighborhood stressors along with strengthening family-level protective factors. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Previous research suggests that having close relationships is a fundamental human need that, when fulfilled, is positively associated with subjective well-being. Recently, however, scholars have argued that actually interacting with one's closest partners may be psychologically taxing (e.g., because of pressures to provide support, care, and empathy). In the present research, we tested (a) how experiential affect varied as a function of which persons were currently present (e.g., romantic partners, friends, and colleagues), as well as (b) how global well-being varied as a function of total daily time invested in these individuals. Replicating previous research, participants reported the highest levels of experiential well-being in the company of their friends, followed by their romantic partners, and then children. Statistically controlling for the activities performed with others, however, suggested that individuals did not necessarily prefer the mere company of their friends per se people reported similar levels of well-being while in the presence of friends, partners, and children when adjusting estimates for activities. In contrast to the experiential findings, global well-being varied only as a function of total time spent with one's romantic partner. Our findings further support the claim that experiential and global well-being are often separable constructs that may show different patterns of association with relationship experiences (e.g., well-being may operate differently on within- vs. between-persons levels). (PsycInfo Database Record (c) 2020 APA, all rights reserved).The day reconstruction method (DRM) is an approach to measuring well-being that is designed to approximate the rich data that can be obtained from intensive repeated measures designs like those used in the experience sampling method (ESM). Although some preliminary tests of the validity of the DRM have been conducted, these typically focus on agreement between the 2 methods at very broad levels, rather than focusing on whether the 2 methods provide similar information about the exact same moments. This article reports 2 studies that use ESM and DRM to assess the same moments. Agreement between the 2 measures varied considerably depending on the focus of the analysis. For aggregate assessments of total time spent in situations and average affect in situations, agreement was high; for between-person differences in time use and experienced affect, agreement varied across situations; and for within-person differences in both situations and affect, agreement was quite low. In addition, we found preliminary evidence that the DRM may be more influenced by expectations regarding the pleasantness of situations as compared with ESM.
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