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© 2020 John Wiley & Sons, Ltd.Imaging brain microvasculature is important in cerebrovascular diseases. However, there is still a lack of non-invasive, non-radiation, and whole-body imaging techniques to investigate them. The aim of this study is to develop an ultra-small superparamagnetic iron oxide (USPIO) enhanced susceptibility weighted imaging (SWI) method for imaging micro-vasculature in both animal (~10 μm in rat) and human brain. We hypothesized that the USPIO-SWI technique could improve the detection sensitivity of the diameter of small subpixel vessels 10-fold compared with conventional MRI methods. Computer simulations were first performed with a double-cylinder digital model to investigate the theoretical basis for this hypothesis. The theoretical results were verified using in vitro phantom studies and in vivo rat MRI studies (n = 6) with corresponding ex vivo histological examinations. Additionally, in vivo human studies (n = 3) were carried out to demonstrate the translational power of the USPIO-SWI method. By directly compaestigations. © 2020 John Wiley & Sons, Ltd.AIM To investigate the clinicopathologic characteristic and fertility results of patients with mucinous borderline ovarian tumors (MBOTs), and the effects of intraepithelial carcinoma (IECA) on them. METHODS Fifty-two patients treated for MBOTs with or without IECA were retrospectively analyzed. RESULTS Patients with IECA were more frequently observed at stage Ic (3/12 vs 1/40, P = 0.034) and accompanied by microinvasive carcinoma (3/12 vs 1/40, P = 0.034). The detected rate of IECA by intraoperative frozen section (5/12, 41.7%) was much lower than that of MBOTs (82.5%, P = 0.010). About 61.5% patients in our study underwent fertility-sparing surgery. Follow-up information was retained completely in 41 patients. And all four tumor recurrences were observed (9.8%) in conservative surgery group in 66 months, though there was no statistical association (P = 0.280). There were three patients who recurred more than once, even one occurred tumor-related death. Only one recurrent patient was in IECA group (P > 0.05). However, patients with IECA were more likely to receive adjuvant chemotherapy (3 of 12 vs 0 of 40, P = 0.010) and surgical staging (75% vs 52.5%, P = 0.200). As for fertility results, nine patients wished to be pregnant and seven of them (77.8%) were successful. CONCLUSION For young patients with MBOTs, fertility results are satisfactory after conservative surgery. But patients should be fully informed about the relative high recurrent rate. And IECA has no statistical negative effects on MBOTs till now, but a long-term follow-up is required. © 2020 Japan Society of Obstetrics and Gynecology.in English, German HINTERGRUND Eine Antibiotikaprophylaxe bei Patienten mit oberer gastrointestinaler Blutung bei Leberzirrhose reduziert das Risiko für bakterielle Infektionen sowie die Frühmortalität signifikant. Ziel der Studie ist es, den aktuellen Stand der Antibiotikaprophylaxe in gastroenterologischen Abteilungen in Deutschland zu erheben. METHODIK Evaluation zu Indikation, Dauer und Wahl des Antibiotikums bei einer Ösophagusvarizenblutung bei Leberzirrhose durch eine Befragung von gastroenterologischen Abteilungen in Deutschland. ERGEBNISSE Von 779 kontaktierten Gastroenterologien haben 326 an der Studie teilgenommen. 98,5 % der befragten Kliniken führen eine prophylaktische Antibiotikagabe bei Ösophagusvarizenblutungen bei Leberzirrhose durch (n = 321/326). Das Child-Pugh-Stadium der Leberzirrhose war nur in 7,1 % (n = 23/322) der Fälle wichtig bei der Entscheidung zur Antibiotikagabe. Eine prophylaktische Antibiotikatherapie wurde auch in 19,4 % (n = 62/320) der Fälle vor einem elektiven Ösophaguetzt den Antibiotikaverbrauch reduzieren.in English, German EINLEITUNG Therapeutisches Drugmonitoring (TDM) ist ein Bestandteil der personalisierten Therapie bei chronisch entzündlichen Darmerkrankungen (CED). Ustekinumab (UST) als monoklonaler Antikörper gegen die p40-Untereinheit der Interleukine 12 und 23 wurde 2016 in Deutschland zur Therapie des M. Crohn (MC) zugelassen. Therapeutische Konzentrationen für UST wurden bisher nicht definiert, weil kaum „Real-World-Daten“ für die UST-Therapie bei MC existieren, die Zusammenhänge zwischen UST-Serumkonzentrationen (cUST) und klinischen Ergebnissen untersuchten. Diese Pilotstudie untersuchte daher bei Patienten mit M. Crohn und einer neu begonnenen UST-Therapie den Zusammenhang zwischen cUST in Woche 8 nach Induktion (cUSTw8) und dem klinischen Ansprechen in Woche 16. METHODIK Aus Serumproben von 72 Patienten mit mittelschwerem bis schwerem MC von 4 tertiären CED-Zentren in Baden-Württemberg, die 8 Wochen zuvor eine Induktionstherapie mit ca. 6 mg/kg Körpergewicht UST als intravenöse Infusion erhaltschen Spiegeln frühzeitig identifiziert werden.Fatigue and overwork have been cited as the main cause of injury with the dance profession. Previous research has shown a difference in workload between professional dancers of different rank, but the role of sex has not been examined. The purpose of this study was to determine workload intensity, rest, and sleep profiles of professional ballet dancers. 48 professional ballet dancers (M=25, F=23) took part in an observational design over 7-14 days using triaxial accelerometer devices. Minutes in METS at different intensities, total time asleep and rest breaks were analysed. check details Significant main effects for rank (p less then 0.001) and rank by sex (p=0.003) for total PA, working day activity, post work activity and sleep. Sleep ranged between 2.4-9.6 h per night. All participants spent more time between 1.5-3 METS outside of work. Significant amounts of exercise where carried out outside of their work day, therefore when injury is reported per 1000 h dance activity, this extra-curricular activity might need to be included. When looking at potential causes of injury in dance, a global perspective of physical activity is required that includes activity outside of work and sleep patterns, all activities that influence physiological recovery. © Georg Thieme Verlag KG Stuttgart · New York.
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