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Voluntary human movements are stereotyped. When modeled in the framework of classical mechanics they are expected to minimize cost functions that may include energy, a natural candidate from a physiological point of view also. In time-changing environments, however, energy is no longer conserved-regardless of frictional energy dissipation-and it is therefore not the preferred candidate for any cost function able to describe the subsequent changes in motor strategies. Adiabatic invariants are known to be relevant observables in such systems, although they still need to be investigated in human motor control. We fill this gap and show that the theory of adiabatic invariants provides an accurate description of how human participants modify a voluntary, rhythmic, one-dimensional motion of the forearm in response to variable gravity (from 1 to 3g). Our findings suggest that adiabatic invariants may reveal generic hidden constraints ruling human motion in time-changing gravity.Many biological systems can be described by finite Markov models. A general method for simplifying master equations is presented that is based on merging adjacent states. Taselisib The approach preserves the steady-state probability distribution and all steady-state fluxes except the one between the merged states. Different levels of coarse graining of the underlying microscopic dynamics can be obtained by iteration, with the result being independent of the order in which states are merged. A criterion for the optimal level of coarse graining or resolution of the process is proposed via a tradeoff between the simplicity of the coarse-grained model and the information loss relative to the original model. As a case study, the method is applied to the cycle kinetics of the molecular motor kinesin.We provide a theoretical analysis by means of the nonperturbative functional renormalization group (NP-FRG) of the corrections to scaling in the critical behavior of the random-field Ising model (RFIM) near the dimension d_DR≈5.1 that separates a region where the renormalized theory at the fixed point is supersymmetric and critical scaling satisfies the d→d-2 dimensional reduction property (d>d_DR) from a region where both supersymmetry and dimensional reduction break down at criticality (d less then d_DR). We show that the NP-FRG results are in very good agreement with recent large-scale lattice simulations of the RFIM in d=5 and we detail the consequences for the leading correction-to-scaling exponent of the peculiar boundary-layer mechanism by which the dimensional-reduction fixed point disappears and the dimensional-reduction-broken fixed point emerges in d_DR.Random walks process on networks plays a fundamental role in understanding the importance of nodes and the similarity of them, which has been widely applied in PageRank, information retrieval, and community detection, etc. An individual's memory has been proved to be crucial to affect network evolution and dynamical processes unfolding on the network. In this work, we study the random-walk process on an extended activity-driven network model by taking account of an individual's memory. We analyze how an individual's memory affects random-walk process unfolding on the network when the timescales of the processes of the random walk and the network evolution are comparable. Under the constraints of long-time evolution, we derive analytical solutions for the distribution of walkers at the stationary state and the mean first-passage time of the random-walk process. We find that, compared with the memoryless activity-driven model, an individual's memory enhances the activity fluctuation and leads to the formation of small clusters of mutual contacts with high activity nodes, which reduces a node's capability of gathering walkers, especially for the nodes with large activity, and memory also delays the mean first-passage time. The results on real networks also support the theoretical analysis and numerical results with artificial networks.We consider the network constraints on the bounds of the assortativity coefficient, which aims to quantify the tendency of nodes with the same attribute values to be connected. The assortativity coefficient can be considered as the Pearson's correlation coefficient of node metadata values across network edges and lies in the interval [-1,1]. However, properties of the network, such as degree distribution and the distribution of node metadata values, place constraints upon the attainable values of the assortativity coefficient. This is important as a particular value of assortativity may say as much about the network topology as about how the metadata are distributed over the network-a fact often overlooked in literature where the interpretation tends to focus simply on the propensity of similar nodes to link to each other, without any regard on the constraints posed by the topology. In this paper we quantify the effect that the topology has on the assortativity coefficient in the case of binary node metadata. Specifically, we look at the effect that the degree distribution, or the full topology, and the proportion of each metadata value has on the extremal values of the assortativity coefficient. We provide the means for obtaining bounds on the extremal values of assortativity for different settings and demonstrate that under certain conditions the maximum and minimum values of assortativity are severely limited, which may present issues in interpretation when these bounds are not considered.Geometric confinement strongly influences the behavior of microparticles in liquid environments. However, to date, nonspherical particle behaviors close to confining boundaries, even as simple as planar walls, remain largely unexplored. Here, we measure the height distribution and orientation of colloidal dumbbells above walls by means of digital in-line holographic microscopy. We find that while larger dumbbells are oriented almost parallel to the wall, smaller dumbbells of the same material are surprisingly oriented at preferred angles. We determine the total height-dependent force acting on the dumbbells by considering gravitational effects and electrostatic particle-wall interactions. Our modeling reveals that at specific heights both net forces and torques on the dumbbells are simultaneously below the thermal force and energy, respectively, which makes the observed orientations possible. Our results highlight the rich near-wall dynamics of nonspherical particles and can further contribute to the development of quantitative frameworks for arbitrarily shaped microparticle dynamics in confinement.
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