Notes

miRNAs within the Period of Tailored Medicine: Through Biomarkers for you to Therapeutics.
To investigate the efficacy of ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis and their impact on quality of life, and to analyze the cost-effectiveness.

A retrospective study was conducted on 215 patients with senile osteoporosis, who were admitted to our hospital from January 2017 to June 2019. Among them, 115 cases treated with ibandronate sodium were set to group A and 100 cases treated with zoledronate sodium were set to group B. The clinical efficacy, bone mineral density (BMD) before and after treatment, bone metabolic markers (alkaline phosphatase (ALP), blood phosphorus (P), blood calcium ion (Ca
)), quality of life, adverse reactions, cost-effectiveness indicators (length of hospitalization, cost) and complications were compared between the two groups.

Total therapeutic response rate in group A was 96.52% (111/115), which was not statistically different from that of 93.00% (93/100) in group B (P=0.242). After treatment, the BMD, ALP, BGP and Ca
levels of tum are similar, both of them can effectively improve the quality of life. However, the cost-effectiveness of ibandronate sodium is better than that of zoledronate sodium.
To explore the effect of care bundles and analyze the influence of different angles of turning over on the sputum excretion of mechanically ventilated patients with severe pneumonia.

120 patients with severe pneumonia in our hospital from October 2016 to October 2019 were equally randomized into four groups, each with 30, according to the date of admission. The control group was given conventional nursing and placed in a position of left 30°-half lying-right 30°; the group A was given comprehensive care bundles and placed in a position of left 30°-half lying-right 30°; the group B was given comprehensive care bundles and placed in a position of left 45°-half lying-right 45°, and the group C was given comprehensive care bundles and placed in a position of 60° left-half lying-60° right. Thiazovivin nmr The respiratory rates and oxygenation indexes of patients in the three groups (group A, B, C) in lateral position at 2 h and 6 h respectively before and after mechanical ventilation were compared. And we compared the nursing efficiency and satisfaction.

The control group showed lower nursing efficiency and satisfaction compared with the group A (P<0.05). The group B and C showed higher oxygenation index after six hours of ventilation compared with group A (P<0.05). After two hours of mechanical ventilation, the group B and C showed lower respiratory rate and higher oxygenation index compared with the group A, and the respiratory rate and oxygenation index of the group B were closest to the normal range (P<0.05).

The sputum excretion effect of mechanically ventilated patients with severe pneumonia was the best if they were placed in a position of left 45°-half lying-right 45° and given comprehensive care bundles.
The sputum excretion effect of mechanically ventilated patients with severe pneumonia was the best if they were placed in a position of left 45°-half lying-right 45° and given comprehensive care bundles.
To investigate the effects of vitamin D drops on immune function in children with recurrent respiratory tract infections (RRTI).

The clinical data of 119 children with RRTI in our hospital were retrospectively retrieved, and they were divided into group A (n=59, receiving routine treatment) and group B (n=60, receiving vitamin D drops) based on their treatment modality. The clinical efficacy, symptom disappearance time, immune function index, insulin-like growth factor (IGF-1), 25-hydroxyvitamin D
[25-(OH)D
], serum y-interferon (INF-y), and the number of episodes of respiratory tract infections were compared between the two groups.

The total effective rate of treatment in group B was 96.67%, which was significantly higher than 71.19% in group A (
<0.05). Children in group B had shorter time to disappearance of lung rales, cough, and fever than group A (
<0.05). Group B had higher IgA, IgG, and IgM levels, higher CD4
, CD3
levels and lower CD8
levels as well as higher IGF-1, 25-(OH)D
, INF-y levels, and fewer respiratory infections after treatment than group A (
<0.05).

Vitamin D drops are effective in the treatment of children with RRTI, which is beneficial to the improvement of clinical symptoms and immune function.
Vitamin D drops are effective in the treatment of children with RRTI, which is beneficial to the improvement of clinical symptoms and immune function.
To explore the effects of off-pump coronary artery bypass grafting (OPC) on clinical efficacy, cardiac function and the occurrence of major adverse cardiovascular events (MACE) in patients with coronary heart disease.

According to different surgical methods, 93 patients with coronary heart disease who were hospitalized and treated in our hospital were collapsed into the off-pump coronary artery bypass grafting group (OPC group) and the extracorporeal circulation coronary artery bypass grafting group (PC group). The perioperative indexes, cardiac function indexes, postoperative recovery, quality of life, the incidence of MACE and adverse reactions and the survival rate of patients in PC group and OPC group were analyzed and compared.

Compared with the PC group, the operation time and blood transfusion volume of OPC group were both largely decreased (P<0.05), but the number of bypass grafts was similar (P>0.05). The cardiac function index of OPC group was much higher than that of PC group (P<0.05). The postoperative recovery after operation of OPC group was better than that of PC group (P<0.05). The scores of quality of life scale in OPC group were markedly higher than those in PC group (P<0.05). The incidence of MACE in OPC group was obviously lower than that in PC group (P<0.05). Patients in in the OPC group had slightly lower incidence of adverse reactions, and slightly higher survival rate than the PC group, but there was no statistical difference (P>0.05).

Compared with PC, OPC has a significantly better therapeutic effect on patients with coronary heart disease, which can significantly improve the perioperative indices and cardiac function, and enhance the quality of life of patients.
Compared with PC, OPC has a significantly better therapeutic effect on patients with coronary heart disease, which can significantly improve the perioperative indices and cardiac function, and enhance the quality of life of patients.
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