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To review the achievements of cardiac exercise rehabilitation programs retrospectively and to identify continuing challenges to their success.
A review of files accumulated while working with the Toronto Rehabilitation Center, updated by articles identified by PUB-MED, OVID, and Google Scholar through February 2019.
After the early lead of Israeli physicians, cardiac rehabilitation began in Ontario during the 1960s and quickly attracted a large case load. Recurrence rates of the patients recruited were low relative to those receiving standard medical treatment, even after allowing for differences in risk factors at entry to programs. Controlled trials began but were individually of insufficient in size to show a significant reduction in recurrences or mortality. Subsequently, multiple meta-analyses demonstrated a 20% to 25% reduction of all-cause and cardiac mortality over the first few years of follow-up in patients who persisted with their rehabilitation. Deutenzalutamide Compliance continued a problem at many centersas established the benefits of exercise-centered cardiac rehabilitation. However, there remains a need to define the optimum timing of program onset, and the frequency, intensity, and duration of supervised training sessions. Return to blue-collar occupations also needs to be boosted, and the limited participation of eligible patients in available programs remains a continuing challenge.
Research conducted in Toronto and elsewhere has established the benefits of exercise-centered cardiac rehabilitation. However, there remains a need to define the optimum timing of program onset, and the frequency, intensity, and duration of supervised training sessions. Return to blue-collar occupations also needs to be boosted, and the limited participation of eligible patients in available programs remains a continuing challenge.
To examine the effect of age and level of competition on subtle motor performance in adolescents who have recently been medically-cleared post-concussion (MC post-concussion) and never-injured controls.
Thirty adolescents who were recently MC post-concussion (12-18 years) and 30 never-concussed, typically-developing controls were examined using the Revised Physical and Neurologic Examination of Subtle Signs (PANESS) and the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) RESULTS Older age was associated with better ImPACT scores in both groups, while only the control group showed improved motor performance on the PANESS with increasing age. Adolescents across both groups participating at a higher level of competition (school or travel level) had better motor performance on the PANESS than those participating at a lower level of competition (recreational level or no sports participation). Adolescents MC post-concussion had greater motor deficits on the PANESS than controls.
Following medical clearance, adolescents with a history of recent concussion demonstrate alterations in the relationship between motor function and age. The PANESS merits further exploration as a measure that is sensitive to factors affecting motor performance such as age and level of athletic competition as well as to persistent subtle motor deficits in adolescents MC post-concussion.
Following medical clearance, adolescents with a history of recent concussion demonstrate alterations in the relationship between motor function and age. The PANESS merits further exploration as a measure that is sensitive to factors affecting motor performance such as age and level of athletic competition as well as to persistent subtle motor deficits in adolescents MC post-concussion.
The aim of the present meta-analysis was to explore the association between FokI polymorphism of the VDR gene and lumbar spine disc degeneration.
The search was performed in PubMed, Scopus and Web of Science databases up to January 2020. We selected nine studies that comprised a total of 1549 cases and 1672 controls. The association analysis included the allelic, dominant, recessive, homozygous and heterozygous genetic models. Odds ratios with 95% confidence intervals were used to evaluate the association. The NOS scale was used to measure the quality of the studies included in the analyses; a cut-off of 6 stars was applied.
This meta-analysis indicated that FokI polymorphism is significantly associated with lumbar degenerative disc disorder and disc herniation in the homozygous (OR 1.77, CI95% 1.23-2.54, Z p value 0.002, Q p value 0.416) and recessive (OR 1.53; CI95% 1.23-1.90, Z p value <0.000, Q p value 0.224) models.
Our study indicates that the VDR gene FokI polymorphism may be correlated with the risk of developing a lumbar degenerative disc disorder and disc herniation. However, the small sample population studied and the lack of an evaluation of environmental factors must be taken as limitations in the present meta-analysis.
Our study indicates that the VDR gene FokI polymorphism may be correlated with the risk of developing a lumbar degenerative disc disorder and disc herniation. However, the small sample population studied and the lack of an evaluation of environmental factors must be taken as limitations in the present meta-analysis.
Increasing exposure to the needs of patients with chronic disability is important in fostering confidence and comfort in disability knowledge and management among medical students and residents of all disciplines. The 2013 Association of American Medical Colleges Graduation Survey of graduating medical students revealed that 33% expressed inadequate exposure to disability management and rehabilitative care. To address this, a 3- to 4-wk rehabilitation elective course was modified to include lectures, media-based reflections, and a hands-on wheelchair experience. Responses and reflections from students from November 2015 to February 2019 were analyzed to assess the impact of the intervention on medical student knowledge and clinical practice using a disability pretest and posttest design. Preintervention data revealed limited knowledge of terminology in disability health that improved greatly in the postelective assessment. Medical students also gained knowledge on disability laws, available resources, and improved identification of appropriate accommodations to limit barriers to care.
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