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5±2.9 vs. 38.4±1.0, p=0.005; THR 1.70±0.16 vs. 0.98±0.07, p<0.001). On the contrary, none of the non-invasive indices of hepatic fibrosis was different between groups. HSI (p=0.038), but not THR, remained inversely independently associated with serum testosterone, after adjustment for potential confounders, including sex hormone-binding globulin.
Men with low testosterone concentrations have higher non-invasive indices of NAFLD (HSI and THR), but not of hepatic fibrosis (APRI, FIB-4, NFS), compared with counterparts of high testosterone concentrations. HSI was inversely and independently associated with testosterone concentrations.
Men with low testosterone concentrations have higher non-invasive indices of NAFLD (HSI and THR), but not of hepatic fibrosis (APRI, FIB-4, NFS), compared with counterparts of high testosterone concentrations. HSI was inversely and independently associated with testosterone concentrations.
Majority of Muslims with type 2 diabetes mellitus (T2DM) fasted during Ramadan regardless of possible risk of complication. This systematic review aims to assess the impact of Ramadan fasting on metabolic profile and hypoglycemia event among T2DM patients.
Literature searching was conducted on December 2019at PUBMED, Medline (EBSCOhost), and ProQuest databases using the following keywords Ramadan fasting, type 2 diabetes mellitus, glycemic and lipid profile, anthropometry measurements, and hypoglycemia. Observational studies in adults and published in English which analyze the glucose parameters, lipid profile, and hypoglycemia among T2DM patients during Ramadan were included in the analysis. All studies were assessed for its risk of bias using New-Castle Ottawa Scale. The heterogeneity of the studies was analyzed using I
(square) test and the overall mean difference between studied parameters before and after Ramadan fasting was calculated using Weighted Mean Difference (WMD) test using Stata 13.
A total of 28 observational studies that were conducted in Middle Eastern, African, and Asian countries were included. This review found decrease in FPG level by-15.28 (95% CI -17.22,-13.34) mg/dl, HbA1c by-0.27 (95% CI -0.32,-0.22)%, total cholesterol by-12.88 (95% CI -14.68,-11.09) mg/dL, LDL-C by-4.42 (95% CI -6.17,-2.66)mg/dl, HDL-C by-1.09 (95% CI -1.71 - 0.47) mg/dL, triglyceride by-2.47 (95% CI -3.69 - 1.24) mg/dL and decreased anthropometry measurement. No studies reported fatal hypoglycemia event.
Ramadan fasting resulted in slight improvement of overall metabolic profile and anthropometry among T2DM patients with relatively low incidence of hypoglycemia.
Ramadan fasting resulted in slight improvement of overall metabolic profile and anthropometry among T2DM patients with relatively low incidence of hypoglycemia.
There is a growing concern about metabolic syndrome among HIV-infected patients. Therefore, this study aims to determine the burden of metabolic syndrome among patients living with HIV/AIDS at referral hospitals of Northwest Ethiopia.
a hospital-based cross-sectional study was conducted at referral hospitals of Northwest Ethiopia between February 2019 and April 2019. Using the WHO stepwise approach, sociodemographic, behavioral, and clinical data were collected from 407 adult patients. Lipid profiles, fasting blood sugar, as well as anthropometric indicators, were also measured. In addition, multivariate binary logistic regression analysis was performed.
The prevalence of metabolic syndrome was found to be 24.6% (95 CI 20.42,28.78). Multivariate logistic regression analysis revealed that age [AOR (95% CI) 1.04 (1.003,1.074), p<0.05]; female gender [AOR (95% CI) 9.66 (4.40, 21.22), p<0.05]; marital status, single referent, separated [AOR (95% CI) 4.77 (1.83, 12.41), p<0.05] and widowed [AOR (95% CI) 3.868(1.375, 10.883), p<0.05]; monthly income (<2000 Ethiopian Birr referent)>5000 ETB [AOR (95% CI) 3.543 (1.299, 9.664), p<0.05]; and urban residence [AOR (95% CI) 2.118 (1.089, 4.119), p<0.05] have shown statistically significant association with odds of metabolic syndrome.
The burden of metabolic syndrome was notably higher. Age, gender, marital status, monthly income, residence, waist circumference, and hypertension of patients were significantly associated with metabolic syndrome.
The burden of metabolic syndrome was notably higher. Age, gender, marital status, monthly income, residence, waist circumference, and hypertension of patients were significantly associated with metabolic syndrome.
Diabetic nephropathy are one of the most important causes of renal failure and dysfunction in diabetic patients and imposes high costs for the healthcare system. Studies conducted in Iran show different prevalence. This study aims to determine the overall prevalence of nephropathy in patients with type 2 diabetes in Iran with a systematic review and meta-analysis.
The present study was carried out by meta-analysis from January 2000 to May 2020. Related articles were obtained through searching in Scopus, Cochrane, Library, ScienceDirect, Embase, SID, Magiran, Barakatkns, Medline (PubMed), and Google Scholar. Heterogeneity of studies was studied using I
index and data were analyzed using Comprehensive Meta-Analysis and Arc map (ArcGIS 10.6) software.
In a review of 18 articles and 6190 subjects aged 20-83 years, the overall prevalence of nephropathy in patients with type 2 diabetes in Iran was 30.6% (95%CI 24.3-37.7) based on a meta-analysis. The highest prevalence of nephropathy in patients with type 2 diabetes was obtained in Tehran province with 57.3% (95%CI 51.5-62.9) in 2008 and the lowest prevalence of nephropathy in patients with type 2 diabetes was obtained in Hamedan province with 14.4% (95%CI 11.3-18.8) in 2016. read more An increase in sample size and research year reduces the prevalence of nephropathy in patients with type 2 diabetes in Iran, and differences were statistically significant (P<0.05).
Considering the high prevalence of nephropathy in patients with type 2 diabetes in Iran, it is essential that health policymakers take effective measures to reduce this disease in diabetic patients.
Considering the high prevalence of nephropathy in patients with type 2 diabetes in Iran, it is essential that health policymakers take effective measures to reduce this disease in diabetic patients.
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