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Transferrin Biosynthesized within the Brain Is a Novel Biomarker pertaining to Alzheimer's Disease.
ve respectively equal to 0.77 and 0.76. This study proves the transferability of a SuStaIn model for AD from research data to less-structured clinical cohorts, and indicates transferability to the clinical setting.[This corrects the article DOI 10.3389/frai.2020.565682.].Many language change studies aim for a partial revisitation, i.e., selecting survey sites from previous dialect studies. The central issue of survey site reduction, however, has often been addressed only qualitatively. Cluster analysis offers an innovative means of identifying the most representative survey sites among a set of original survey sites. In this paper, we present a general methodology for finding representative sites for an intended study, potentially applicable to any collection of data about dialects or linguistic variation. We elaborate the quantitative steps of the proposed methodology in the context of the "Linguistic Atlas of Japan" (LAJ). Next, we demonstrate the full application of the methodology on the "Linguistic Atlas of German-speaking Switzerland" (Germ. "Sprachatlas der Deutschen Schweiz"-SDS), with the explicit aim of selecting survey sites corresponding to the aims of the current project "Swiss German Dialects Across Time and Space" (SDATS), which revisits SDS 70 years later. We find that depending on the circumstances and requirements of a study, the proposed methodology, introducing cluster analysis into the survey site reduction process, allows for a greater objectivity in comparison to traditional approaches. We suggest, however, that the suitability of any set of candidate survey sites resulting from the proposed methodology be rigorously revised by experts due to potential incongruences, such as the overlap of objectives and variables across the original and intended studies and ongoing dialect change.Epilepsy is a complex brain disorder characterized by repetitive seizure events. Epilepsy patients often suffer from various and severe physical and psychological comorbidities (e.g., anxiety, migraine, and stroke). While general comorbidity prevalences and incidences can be estimated from epidemiological data, such an approach does not take into account that actual patient-specific risks can depend on various individual factors, including medication. This motivates to develop a machine learning approach for predicting risks of future comorbidities for individual epilepsy patients. In this work, we use inpatient and outpatient administrative health claims data of around 19,500 U.S. epilepsy patients. We suggest a dedicated multimodal neural network architecture (Deep personalized LOngitudinal convolutional RIsk model-DeepLORI) to predict the time-dependent risk of six common comorbidities of epilepsy patients. We demonstrate superior performance of DeepLORI in a comparison with several existing methods. Moreover, we show that DeepLORI-based predictions can be interpreted on the level of individual patients. Using a game theoretic approach, we identify relevant features in DeepLORI models and demonstrate that model predictions are explainable in light of existing knowledge about the disease. Finally, we validate the model on independent data from around 97,000 patients, showing good generalization and stable prediction performance over time.Research into Explainable Artificial Intelligence (XAI) has been increasing in recent years as a response to the need for increased transparency and trust in AI. This is particularly important as AI is used in sensitive domains with societal, ethical, and safety implications. Work in XAI has primarily focused on Machine Learning (ML) for classification, decision, or action, with detailed systematic reviews already undertaken. This review looks to explore current approaches and limitations for XAI in the area of Reinforcement Learning (RL). From 520 search results, 25 studies (including 5 snowball sampled) are reviewed, highlighting visualization, query-based explanations, policy summarization, human-in-the-loop collaboration, and verification as trends in this area. Limitations in the studies are presented, particularly a lack of user studies, and the prevalence of toy-examples and difficulties providing understandable explanations. Areas for future study are identified, including immersive visualization, and symbolic representation.Routine blood pressure (BP) measurement in pregnancy is commonly performed using automated oscillometric devices. Since no wireless oscillometric BP device has been validated in preeclamptic populations, a simple approach for capturing readings from such devices is needed, especially in low-resource settings where transmission of BP data from the field to central locations is an important mechanism for triage. To this end, a total of 8192 BP readings were captured from the Liquid Crystal Display (LCD) screen of a standard Omron M7 self-inflating BP cuff using a cellphone camera. A cohort of 49 lay midwives captured these data from 1697 pregnant women carrying singletons between 6 weeks and 40 weeks gestational age in rural Guatemala during routine screening. Images exhibited a wide variability in their appearance due to variations in orientation and parallax; environmental factors such as lighting, shadows; and image acquisition factors such as motion blur and problems with focus. MLN8054 Images were independently labeled for readability and quality by three annotators (BP range 34-203 mm Hg) and disagreements were resolved. Methods to preprocess and automatically segment the LCD images into diastolic BP, systolic BP and heart rate using a contour-based technique were developed. A deep convolutional neural network was then trained to convert the LCD images into numerical values using a multi-digit recognition approach. On readable low- and high-quality images, this proposed approach achieved a 91% classification accuracy and mean absolute error of 3.19 mm Hg for systolic BP and 91% accuracy and mean absolute error of 0.94 mm Hg for diastolic BP. These error values are within the FDA guidelines for BP monitoring when poor quality images are excluded. The performance of the proposed approach was shown to be greatly superior to state-of-the-art open-source tools (Tesseract and the Google Vision API). The algorithm was developed such that it could be deployed on a phone and work without connectivity to a network.
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