Notes

Predictors regarding development of palbociclib-induced neutropenia throughout breast cancer patients because determined by ordered logistic regression evaluation.
biochemical recurrence; CPT Current Procedural Terminology; EBRT external beam radiation therapy; IQR, interquartile ranges; LOS length of stay; PLND pelvic lymph node dissection; PSM positive surgical margin; (O)(RA)RP, (open) (robot-assisted) radical prostatectomy.
This is the largest RARP series from the Middle East. The surgical, oncological and functional outcomes are consistent with those published in the literature. This confirms the safety and efficacy of applying robotic technology in our region during the implementation phase.Abbreviations ADT androgen-deprivation therapy; AJCC American Joint Committee on Cancer; AUBMC American University of Beirut Medical Center; BCR biochemical recurrence; CPT Current Procedural Terminology; EBRT external beam radiation therapy; IQR, interquartile ranges; LOS length of stay; PLND pelvic lymph node dissection; PSM positive surgical margin; (O)(RA)RP, (open) (robot-assisted) radical prostatectomy.Objectives To compare the outcomes of standard- and mini-percutaneous nephrolithotomy (PCNL) for the treatment of staghorn stones. Patients and Methods The data of consecutive adult patients who underwent PCNL for the treatment of staghorn stones, between July 2015 and December 2019 from three hospitals, were retrospectively reviewed. All cases were performed in a prone position under fluoroscopic guidance. The nephrostomy tracts were dilatated to 30 F in standard-PCNL and to 18-20 F in mini-PCNL. Stones were fragmented with pneumatic lithotripsy in both groups. Fragments were removed with forceps in the standard-PCNL, while they were evacuated through the sheath using the vacuum clearance effect in mini-PCNL. A ureteric stent was inserted after mini-PCNL, while a nephrostomy tube was inserted after standard-PCNL. Results The study included 153 patients; 70 underwent standard-PCNL and 83 underwent mini-PCNL. The stone-free rates of PCNL monotherapy were comparable for both groups (83% for mini-PCNL and 88.6% for standard-PCNL, P = 0.339). The incidence (12% vs 24.3%, P = 0.048) and severity of complications were significantly lesser with mini-PCNL (P = 0.031). Standard-PCNL was associated with increased rate of blood transfusion (12.9% vs 2.4%, P = 0.013) and a significant decrease in haemoglobin (P = 0.018). Hospital stay was significantly longer for standard-PCNL than mini-PCNL (median stay of 6 vs 3 days, P less then 0.001). Conclusions The efficacy of mini-PCNL was comparable to standard-PCNL in the treatment of staghorn stones. The advantages of mini-PCNL included a lesser incidence and severity of complications, and shorter hospital stay.Objectives To study a modification to the conventional retrograde ureteroscopic approach for treating proximal ureteric stones of 1-2 cm; we intentionally push the stone from the proximal ureter into a favourable calyx then the flexible ureteroscope is used to fragment the trapped stone using laser lithotripsy ('boxing in the corner'). Patients and methods The study was conducted in a randomised prospective manner and included 100 patients who presented with a single proximal ureteric stone of 1-2 cm. We randomised the patients into two equal groups Group A (50 patients) underwent the conventional retrograde technique (CRT) and Group B (50 patients) underwent the modified retrograde technique (MRT) with the primary intention of relocating the stone into a favourable calyx. AB680 Intended relocation of the proximal ureteric stone in the MRT group was achieved in a stepwise manner. All intraoperative parameters and postoperative outcomes were recorded and compared between the two groups. Results There was no statistical significant difference in terms of the patients' demographics and stone criteria between the two groups. The stone-free rate (SFR) was significantly higher in Group B (92%) compared to Group A (78%) (P = 0.049). Fluoroscopy time was significantly longer in Group B (P less then 0.001), while operative time, lithotripsy time and hospital stay were comparable. There was no difference between the groups regarding complications. Conclusion The MRT was found to be safe and more effective than the CRT for treating proximal ureteric stones of 1-2 cm, with a significantly higher SFR. Abbreviations CONSORT Consolidated Standards of Reporting Trials; ESWL extracorporeal shockwave lithotripsy; fURS flexible ureteroscope; NCCT non-contrast CT; SFR stone-free rate; YAG yttrium-aluminium-garnet.
To compare emergency with elective ureteroscopy (URS) for the treatment of a single ureteric stone.

The files of adult patients with a single ureteric stone were retrospectively reviewed. Patients with fever or turbid urine on passage of the guidewire beside the stone underwent ureteric stenting or nephrostomy drainage. Patients who underwent URS were included and divided into two groups the emergency (EM) Group, those who presented with persistent renal colic and underwent emergency URS within 24h; and the elective (EL) Group, who underwent elective URS after ≥14days of diagnosis. Patients with ureteric stents were excluded. The technique for URS was the same in both groups. Safety was defined as absence of complications. Efficacy was defined as the stone-free rate after a single URS session.

From March 2015 to September 2018, 179 patients (107 in the EM Group and 72 in the EL Group) were included. There were significantly more hydronephrosis and smaller stones in the EM Group (
=0.002 and
=0.001, KUB plain abdominal radiograph of the kidneys, ureters and bladder; MET medical expulsive therapy; NCCT non-contrast CT; SFR stone-free rate; SWL shockwave lithotripsy; URS ureteroscopy.
To present the 12-month outcomes of 'Top-Down' holmium laser enucleation of the prostate (HoLEP).

We retrospectively reviewed the charts of prospectively collected patients who underwent Top-Down HoLEP between 2017 and 2018. All cases were operated upon by a single urologist (H.E), using a 100-W holmiumYAG laser with a 550-μm laser fibre. We recorded the enucleation time, morcellation time, intraoperative, and postoperative complications. All patients had postoperative follow-up visits at 1, 3, 6 and 12months. The evaluation included the International Prostate Symptom Score (IPSS), quality-of-life (QoL) assessment, measurement of maximum urinary flow rate (Q
) and the post-void residual urine volume (PVR).

A total of 60 consecutive patients were recruited. The median (range) prostatic volume, resected prostatic weight, and percentage of resected prostatic tissue were 124 (70-266) mL, 90 (44-242) g and 76 (46-97)%, respectively. The median (range) enucleation and morcellation times were 80 (25-200) and 14.
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