Notes

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The rate of exposure to methamphetamine in the US declined initially following passage of the Combat Methamphetamine Epidemic Act of 2005. However, since 2007, the rate and severity of exposures to methamphetamine have increased, primarily driven by individuals 20 years or older. Increased prevention efforts are needed, including prevention of methamphetamine initiation among adolescents and young adults, improved access to effective treatment for co-occurring mental health and substance use disorders, and prevention of unintentional exposures among children.
Population growth is an important public health problem with economic, social, cultural and political consequences. The aim of the study was to determine the reproductive behaviour and perspectives on fertility of women in Sanliurfa, the city with the highest fertility rate in Turkey.

The quantitative dimension of the study was carried out using a mixed methods approach in which 300 women were interviewed and a questionnaire was completed; the qualitative dimension was carried out through in-depth individual interviews with 14 women, using a semi-structured interview form. Analysis of the qualitative data was done using a content analysis technique.

The median number of children was three (range 0-10). Women with no or a low level of education tended to have a greater number of children. Preference for a particular sex of child was one reason behind the higher number of children. These two factors were main causes of an increased number of children. Women with no or a low level of education (odds ratio [OR] 9.1) and women who expressed a preference for a male child (OR 5.9) had more children compared with other women. VX-702 supplier Participants regarded a male child as more valuable than a female child and that having many children strengthened the family. Parents regarded their sons as insurance for their old age. Having an induced abortion was perceived as a sin.

The results showed that cultural norms and values significantly affected fertility rates.
The results showed that cultural norms and values significantly affected fertility rates.
We evaluated the feasibility of a multi-level teleaudiology patient-site facilitator training program for Community Health Workers (CHWs) at a partnering health centre in southern Arizona.

Three levels were offered Introductory, with basic information on hearing loss and teleaudiology; Intermediate, on technology, team roles, and access issues; and Facilitator, on further knowledge and hands-on skills to serve as patient-site facilitators in synchronous hearing aid service delivery. Six domains of feasibility were addressed using a mixed-methods design. Quantitative data included survey responses and observation of hands-on skills. Qualitative data included field notes from group discussion and open-ended survey questions, and were analysed using CHW core competencies.

Twelve CHWs participated in the introductory training, ten moved on to intermediate, and three continued to the facilitator.

Quantitative outcomes indicated that the trainings were feasible according to each of the six domains. CHWs in the facilitator training passed the practical hands-on skill assessment. Qualitative analyses revealed CHWs comments addressed eight of the ten possible CHW core competencies, and focussed on service coordination/navigation, and capacity building.

Teleaudiology trainings for CHWs were feasible, increasing service capacity for a potential pathway to improve access to hearing health care in low-resource areas.
Teleaudiology trainings for CHWs were feasible, increasing service capacity for a potential pathway to improve access to hearing health care in low-resource areas.We analyze the functional connectivity of the cortico-cardiac-muscular network during muscle fatigability due to exercise. For our experiments, we recruited ten volunteers who performed two cycling routines. Our volunteers were classified according to physical activity level as active or sedentary. First, we measured the electromyography (EMG) signal of the vastus lateralis muscle to find the volunteer's individualized physical workload capacity at the fatigue threshold. Two to three days later, we measured the volunteers' EMG, electrocardiography, and electroencephalography (EEG) data during the development of muscle fatigue with the individualized pedaling load previously obtained. We analyzed the EEG to identify the brain rhythm with highest power, then functional connectivity was assessed by computing the pairwise partial directed coherence of our measurements at such rhythm. Finally, we assessed significant changes in functional connectivity from start to finish of the exercise. Our results indicate that the sedentary group showed a significant decrease in connectivity, while the active group showed an increase in left-frontal connectivity. This might be explained in terms of frontal asymmetry phenomena which, for the case of active volunteers, may be a reflection of positive emotional states. Additionally, the active group showed increased self-regulatory processes in heart and muscle, while the sedentary group showed a decreased connectivity from heart to muscle together with a reduction in the muscle's self-regulation. These last results may be explained by a preference of the body in the sedentary group to attend vital requirements instead of exercise.
For many agents, the aerodynamic particle size can affect both the virulence and disease course in animal models. Botulinum neurotoxins (BoNTs), which are widely known as potential bioterrorism agents, have been shown to be toxic via multiple routes of exposure, including small particle inhalation (1-3 µm MMAD). However, the impact of larger particle sizes on the potency of BoNT has not been previously reported. In this study, we compared the potency of BoNT in small and large particle aerosols.

Outbred mice (ICR (CD-1
)) were exposed to BoNT-containing aerosols with differing mass median aerodynamic diameters (MMADs) of 1.1, 4.9, and 7.6 microns. The effects of bioaerosol sampler and inhalation exposure modality were studied.

Collecting aerosolized BoNT onto gelatin filters or into liquid impingers resulted in equivalent estimates of aerosol concentration. Nose-only and whole-body inhalation exposure resulted in nearly identical estimates of the median lethal dose (LD
). The LD
for inhaled BoNT increased approximately 50-fold when the median aerodynamic particle size was increased from 1.
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