Notes

DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer's Disease inside a Oriental Human population.
405, 95% confidence interval (CI) 1.702-269.233, P=0.018].

Obesity or overweight and FSH/LH had association with GLM recurrence, and the difference of PRL level before and after treatment is the independent risk factor of recurrence. Clinical examination of hormone levels especially the PRL level should not be ignored during and even after the treatment of GLM.
Obesity or overweight and FSH/LH had association with GLM recurrence, and the difference of PRL level before and after treatment is the independent risk factor of recurrence. Clinical examination of hormone levels especially the PRL level should not be ignored during and even after the treatment of GLM.
Whether challenging video-assisted thoracoscopic surgery (VATS) is a minimal invasive surgery remains controversial. This study aimed to analyze causes of challenging conventional multiple-port VATS (CVATS) and conversion to thoracotomy and postoperative pain to provide indications for VATS.

This was a two-center retrospective study. Challenging VATS was defined as CVATS with operation time ≥5 hours and it was converted to thoracotomy. This study included patients who were admitted to Joetsu General Hospital (Joetsu, Niigata, Japan) and Toyama University Hospital (Toyama, Japan) for elective CVATS between April 2013 and March 2019. The exclusion criteria were as follows a planned thoracotomy, uniportal VATS, robot-assisted thoracoscopic surgery, and simultaneous resection of extrathoracic organs.

A total of 911 (91.6%) patients underwent CVATS. Of these cases, 876 (96.2%) were suitable VATS cases. On the contrary, 35 cases (3.8%) were recognized as challenging VATS. In 21 (2.3%) cases, VATS took ≥5 hourostoperative neuropathic pain. In case of bronchoplasty, angioplasty, and large tumor with minimum diameter ≥5 cm, a thoracotomy approach would be appropriate depending on the skill and experience of the surgeon. In cases of local or vascular sheath adhesion, if operation progress is delayed, it may be necessary to set a time limit and decide to convert to thoracotomy, considering patient's safety first.
New evidence from retrospective cohort studies on risk of death from COVID-19 infection became available. We aimed to systematically review the clinical risk factors for fatal outcome of COVID-19.

We performed meta-analysis, using PubMed, EMBASE and Cochrane databases from December 1 2019 to June 10 2020. The meta-analysis summarized clinical, laboratory, radiological features, and complications of non-survivors with confirmed COVID-19. In addition, a fixed- or random-effects model was adopted based on the heterogeneity among studies. We also used funnel-plot with Egger's tests to screen potential publication bias.

In total, twenty studies with 15,408 COVID-19 cases were included in our meta-analysis. Male, current smoking, and older age were associated with in-hospital death. Patients aged 60 years or over had the highest pooled ORs [OR 4.94 (2.89, 8.44)]. Non-survivors were more likely to have diabetes, hypertension, cardiovascular disease (CVD), respiratory disease, or chronic kidney disease (CKD). Rh as diabetes, hypertension, CVD, respiratory disease, and CKD could also influence the prognosis of the COVID-19. Clinical feature such as dyspnea and fatigue could imply the exacerbation and even death. Our findings highlighted early markers of mortality which were beneficial to identify fatal COVID-19.
Due to the advancements in medicine coupled with the aging population, palliative care has become widely needed. In many countries, medical students are trained in palliative care in their postgraduate courses. However, palliative care education is not available as an independent course or standardized training for residents in China.

This parallel randomized controlled trial was conducted in the Department of Internal Medicine, Beijing Chao-yang Hospital, Capital Medical University, between June 2016 and August 2017. The aim of the study was to explore the impact of the palliative care education and training program on 72 residents who were trained in standardization and were randomly divided into experimental and control groups at the ratio 11. The experimental group received resident physician standardized training and palliative care training program, while the control group received only standardized training. Standardized training included training in humanistic medical skills. PF-06826647 purchase The two groups were t relieve patients of terminal discomfort. The educational promotion of palliative care is of great value in China.
Exercise therapy is an important component of non-drug treatment for Parkinson's disease (PD). However, the impact of moderate aerobic exercise on PD remains unclear. The purpose of this systematic review was to evaluate the efficacy and safety of moderate aerobic exercise for patients with PD.

Databases including the Cochrane Library, PubMed, Web of Science, EMBASE, Chinese Biomedical Literature (CBM) Database, Chinese National Knowledge Infrastructure (CNKI), WanFang, and the Weipu Database for Chinese Technical Periodicals (VIP) were searched electronically from the date of inception of the database to June 2020 to recruit relevant randomized controlled trials (RCTs) investigating the efficacy and safety of moderate aerobic exercise on balance and other symptoms in patients with PD. Literature screening, data extraction, and quality evaluation were carried out. Revman5.1 (http// ims.cochrane.org/revman) was used for data analysis.

In total, nine RCTs with 444 patients were included in this study. Moseffectively improves balance and gait in patients with PD, but the effect on motor symptoms is not obvious. Different exercise styles have varying effects on the quality of life of PD patients. It is necessary to standardize the exercise program further and carry out indepth research in the future.
Scutellarin (Scu) shows both anti-inflammatory and antioxidant activities. The study investigates cardioprotective effects of Scu in mice with type 1 diabetes and the underlying molecular mechanism.

Streptozotocin (STZ) was used to induce diabetic cardiomyopathy (DCM) in C57BL/6 mice by intraperitoneal injection (i.p.). Normal and diabetic mice were divided into 6 groups control, diabetic model group (DM), DM + Scu (5 mg/kg), DM + Scu (10 mg/kg), DM + Scu (20 mg/kg), DM + pioglitazone (Pio) (10 mg/kg). Scu was administered to the mice intraperitoneally and Pio was administrated by oral. Mice in control and DM groups were simply treated normal saline. Four weeks later, myocardial function, myocardial fibrosis, the levels inflammatory factors and oxidative stress were detected.

Scu improved cardiac function and reduced heart injury in diabetic mice, which was indicated by increasing Left ventricular (LV) end-diastolic volume (LVVd), fractional shortening (FS), and ejection fraction (EF) levels and decreased pathological changes of heart.
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