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Ultrasound-Guided Side-line Iv Catheter Insertion Instruction Reduces Utilization of Midline Catheters in In the hospital Patients Along with Tough Intravenous Entry.
Lower extremity procedures were associated with a significantly higher rate of VTE than expected. Over 90% of respondents reported using a patient risk stratification assessment tool. Although at least half of respondents reported that the surgical facility in which they operate maintains some form of VTE prophylaxis protocol, 39% self-reported non-adherence with these protocols. CONCLUSIONS There is considerable variability in VTE prophylaxis practices among the ASAPS responders. Future efforts should simplify guidelines and tailor prophylaxis recommendations to the aesthetic surgery population. Furthermore, education of plastic surgeons performing aesthetic surgery and more diligent surgical venue supervision is needed to narrow the gap between current recommendations and actual practices. © 2020 The Aesthetic Society. Reprints and permission [email protected] is a progressive vascular disease with increasing morbidity and mortality year by year in modern society. Human cytomegalovirus (HCMV) infection is closely associated with the development of atherosclerosis. HCMV infection may accelerate graft atherosclerosis and the development of transplant vasculopathy in organ transplantation. However, our current understanding of HCMV-associated atherosclerosis remains limited and is mainly based on clinical observations. The underlying mechanism of the involvement of HCMV infection in atherogenesis remains unclear. Here, we summarized current knowledge regarding the multiple influences of HCMV on a diverse range of infected cells, including vascular endothelial cells, vascular smooth muscle cells, monocytes, macrophages, and T cells. In addition, we described potential HCMV-induced molecular mechanisms, such as oxidative stress, endoplasmic reticulum stress, autophagy, lipid metabolism, and miRNA regulation, which are involved in the development of HCMV-associated atherogenesis. Gaining an improved understanding of these mechanisms will facilitate the development of novel and effective therapeutic strategies for the treatment of HCMV-related cardiovascular disease. © The Author(s) 2020. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail [email protected] thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder caused by neutralizing anti-ADAMTS13 autoantibodies. In Caucasians, human leukocyte antigen (HLA) allele DRB1*11 was a predisposing factor for iTTP, while DRB1*04 was a protective factor. However, the role of HLA in Asians is unclear. In this study, we analyzed 10 HLA loci using next-generation sequencing (NGS) in 52 Japanese patients with iTTP, and the allele frequency in the iTTP group was compared to that in a Japanese control group. We identified the following HLA alleles as predisposing factors for iTTP in the Japanese population DRB1*0803 (odds ratio [OR] 3.06, corrected P-values [Pc]=0.005), DRB3/4/5*blank (OR 2.3, Pc=0.007), DQA1*0103 (OR 2.25, Pc=0.006), and DQB1*0601 (OR 2.41, Pc=0.003). The estimated haplotype consisting of these 4 alleles was significantly more frequent in the iTTP group than in the control group (30.8% vs. 6.0%, Pc less then 0.001). DRB1*1501 and DRB5*0101 were weak protective factors for iTTP (OR 0.23, Pc=0.076; and OR 0.23, Pc=0.034, respectively). On the other hand, DRB1*11 and DRB1*04 were not associated with iTTP in Japanese. These findings indicated that predisposing and protective factors for iTTP differ between Japanese and Caucasians. HLA-DR molecules encoded by DRB1*0803 and DRB1*1101 have different peptide-binding motifs, but interestingly, were capable of binding to the shared ADAMTS13 peptide in an in silico prediction model. Copyright © 2020 American Society of Hematology.Maximal Strength Training (MST) results in robust improvements in skeletal muscle force production, efficiency, and mass. However, the effects of MST on muscle mitochondria is still unknown. selleck Accordingly, the purpose of this study was to examine, from the molecular level to whole-muscle, mitochondrial adaptations induced by 8 weeks of knee-extension MST in the quadriceps of 10 older adults using immunoblotting, spectrophotometry, high-resolution respirometry in permeabilized muscle fibers, in vivo31P magnetic resonance spectroscopy (31P-MRS) and gas exchange. As anticipated, MST resulted in an increased isometric knee-extensor force from 133±36 to 147±49 Nm (P less then 0.05) and quadriceps muscle volume from 1410±103 to 1555±455 cm3 (P less then 0.05). Mitochondrial complex (I-V) protein abundance and citrate synthase activity were not significantly altered by MST. Assessed ex vivo, maximal ADP-stimulated respiration (state 3CI+CII, PRE 23±6 and POST 14±5 ρM·mg-1·s-1, P less then 0.05), was decreased by MST, predominantly, as a result of a decline in complex I linked respiration (P less then 0.05). Additionally, state 3 free-fatty acid linked respiration was decreased following MST (PRE 19±5 and POST 14±3 ρM·mg-1·s-1, P less then 0.05). Assessed in vivo, MST slowed the PCr recovery time constant (PRE 49±13 and POST 57±16 s, P less then 0.05) and lowered, by ~20% (P=0.055), the quadriceps peak rate of oxidative ATP synthesis, but did not significantly alter the oxidation of lipid. Although these, likely qualitative, mitochondrial adaptations are potentially negative in terms of skeletal muscle energetic capacity, they need to be considered in light of the many improvements in muscle function that MST affords older adults. © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail [email protected] Bladder cancers invading the muscularis mucosae (MM) are treated differently from those invading the muscularis propria (MP). However, it may be difficult to determine the type of smooth muscle in transurethral resection (TUR) or biopsy specimens. We aimed to investigate the clinicopathologic features of bladder cancers involving smooth muscle of indeterminate type (SMIT) in TUR specimens in comparison with those invading the MM. METHODS We identified 103 patients with bladder cancer involving SMIT (n = 27) or the MM (n = 76) in TUR specimens. All patients underwent subsequent restaging TUR or cystectomy. RESULTS Bladder cancer with SMIT invasion showed a significantly higher rate of MP invasion in the subsequent specimens than those invading the MM (52% vs 29%). Lack of MP in the TUR specimens had a significantly higher risk of MP invasion in the subsequent specimens than those with the MP (61% vs 40%). The overall survival time for patients with SMIT invasion was significantly shorter than those with MM invasion.
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