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future dissemination of similar programs.
Implementation and evaluation of an evidence-based physical activity program, in a low-resource setting, are feasible and yield relevant information about program adaptations and future dissemination of similar programs.Physical activity occurs in 4 domains (leisure, occupational, household, and transportation), but US surveillance often focuses on leisure-time only. We compared estimates of self-reported leisure-time physical activity and estimates of all-domain activity among adults in the National Health and Nutrition Examination Survey for 2011-2016. During the study period, 38.6% met the aerobic physical activity guideline in leisure-time, 58.5% in leisure-time and occupational/household activity, and 63.7% in all domains. Differences within most subgroups when using all domains were similar to differences when using leisure-time activity only, except that we observed no urban/rural differences in the multidomain assessment. Assessment of multiple domains of activity instead of leisure-time-only activity affects prevalence estimates to a greater extent than it affects subgroup differences.
Little is known about the social needs of low-income households with children during the coronavirus-2019 (COVID-19) pandemic. check details Our objective was to conduct a cross-sectional quantitative and qualitative descriptive analysis of a rapid-response survey among low-income households with children on social needs, COVID-19-related concerns, and diet-related behaviors.

We distributed an electronic survey in April 2020 to 16,435 families in 4 geographic areas, and 1,048 responded. The survey asked families enrolled in a coordinated school-based nutrition program about their social needs, COVID-19-related concerns, food insecurity, and diet-related behaviors during the pandemic. An open-ended question asked about their greatest concern. We calculated descriptive statistics stratified by location and race/ethnicity. We used thematic analysis and an inductive approach to examine the open-ended comments.

More than 80% of survey respondents were familiar with COVID-19 and were concerned about infection. Overall, 76.3% reported concerns about financial stability, 42.5% about employment, 69.4% about food availability, 31.0% about housing stability, and 35.9% about health care access. Overall, 93.5% of respondents reported being food insecure, a 22-percentage-point increase since fall 2019. Also, 41.4% reported a decrease in fruit and vegetable intake because of COVID-19. Frequency of grocery shopping decreased and food pantry usage increased. Qualitative assessment identified 4 main themes 1) fear of contracting COVID-19, 2) disruption of employment status, 3) financial hardship, and 4) exacerbated food insecurity.

Our study highlights the compounding effect of the COVID-19 pandemic on households with children across the spectrum of social needs.
Our study highlights the compounding effect of the COVID-19 pandemic on households with children across the spectrum of social needs.
Curcumin is a natural polyphenol and lead compound of the rhizomes of curcuma longa that it has been widely used for pharmacological activities.

In this study, series of novel derivatives of curcumin, which this group was linked to a 2-amino-4-phenylpyran-3-carbonitrile system, have been synthesized and tested for their antitumor activities in-vitro against a panel of three human cancer cell lines (MCF-7, A2780, and U-87MG).

The in-vitro cytotoxic activity of the synthesized compounds was tested on three cancer cell lines (MCF-7, A2780, and U87MG) using MTT colorimetric assay. Meanwhile, the ability of the active compounds to induce apoptosis in cancer cells was investigated by examination of caspase-3 and caspase-9 and mitochondrial membrane potential assay.

Under relatively mild conditions in ethanol, the reaction of a series of substrates afforded the corresponding derivatives of curcumin mostly in good yields (13 analogues, 48-94% yields). Bioassay results indicated that compounds L6 (para-Bromo), L9 (paraNitro) and L12 (meta-Methoxy) were the most active members in this study demonstrating potent activities against A2780 cancer cells and experimental results of fluorescent staining and flow cytometry analysis revealed that L6 and L9 could induce apoptosis in A2780 cells with apoptosis ratios of about 40% and 46%, respectively at 24 h of treatment at 15.35 µM and 23µM in A2780 cells. On the other hand, they could increase the caspase-3 activity slightly (10%), while had no significant impact on the activities of caspase-9.

Those two derivatives could be considered as useful templates for future development to obtain more potent antitumor agents.
Those two derivatives could be considered as useful templates for future development to obtain more potent antitumor agents.
This systematic review aims to investigate the role and responsibilities of pharmacists in prevention of medication errors. Also to evaluate pharmacist-centered strategies that has an impact in medication error reduction and prevention.

A search was conducted through the following databases PubMed Central, Scopus, Trip, Prospero, Medline and Google Scholar using terms related to "medication errors prevention" or "pharmacist-related errors". Other search terms included "pharmacis t(s)", "prevention", "medication error (s)", "dispensing error (s)", "drug incidence (s)", "medication malpractice (s)". Included studies were prospective and retrospective cohort, case-control and cross-sectional full-text studies published in the last 10 years (2010-2020). The review team screened the articles for inclusion criteria and evaluated the quality of the articles. The PRISMA Guidelines were used to report the selected articles and screening process. Then, the articles was sent to a third independent reviewer for qualiumber of medication errors and an increase in medication error identification and awareness. These findings suggest the crucial role of pharmacist in healthcare policies for the prevention of medication errors and patient safety.

This systematic review suggests multiple pharmacist-centered strategies that have been implemented in several studies showing the positive impact in the reduction and prevention of medication errors commenced by not only the pharmacist but the rest of the healthcare team.
This systematic review suggests multiple pharmacist-centered strategies that have been implemented in several studies showing the positive impact in the reduction and prevention of medication errors commenced by not only the pharmacist but the rest of the healthcare team.
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