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Lithium-Induced Hyperparathyroidism: A good Ill-defined Territory.
The objectives of this study are to experimentally investigate the effects of the dielectric material and the package stiffness on the durability and the efficiency of a previously developed triboelectric-based instrumented knee implant prototype. Navitoclax in vivo The proposed smart knee implant may provide useful information about prosthesis health and its functionality after a total knee replacement (TKR) by routine monitoring of tibiofemoral load transfer without the need for any external power source. The triboelectric powered load sensing by the proposed TKR system needs to be functional throughout the entire life of a knee replacement. The power output of the triboelectric system depends on the surface charge generations and accumulations on its dielectric material, and the force that transmits through its housing into the tribo-materials. The properties of the dielectric material and the package stiffness can significantly influence the reliability of the proposed device. For such a TKR system, a compliant mechanism with the ideal material selection can improve its state of the art. We investigated the performance of three vertical contact mode triboelectric generators made with three different dielectric materials polydimethylsiloxane (PDMS), fluorinated ethylene propylene (FEP), and polytetrafluoroethylene (PTFE). To investigate the effect of package stiffness, we tested two Ti-PDMS-Ti harvesters inside a polyethylene and a Ti6Al4V package. At 1500 N of sinusoidal loads, the harvesters could generate 67.73 μW and 19.81 μW of mean apparent power in parallel and single connections in the polyethylene package, which was 32 and 17 times greater than the power recorded in the Ti assembly, respectively.The increasing prevalence of pulmonary ailments including asthma, chronic obstructive pulmonary disorder, lung tuberculosis, and lung cancer, coupled with the success of pulmonary therapy, has led to a plethora of scientific research focusing on improving the efficacy of pulmonary drug delivery systems. Recent advances in nanoscience and nano-engineering help achieve this by developing stable, potent, inhalable nanosize drug formulations that potentially increase dosages at target sites with significant therapeutic effects. In this study, we numerically analyze a novel methodology of incorporating helical air-nanoparticle streams for pulmonary nanotherapeutics, using a customized version of the open-source computational fluid dynamics (CFD) toolbox openfoam. As nanoparticles predominantly follow streamlines, helical airflow transports them in a centralized core along the human upper respiratory tract, thereby minimizing deposition and hence waste on the oropharyngeal walls, potentially also reducing the risk of drug-induced toxicity in healthy tissues. Advancing our previous study on micron-particle dynamics, helical streams are shown to improve the delivery of nanodrugs, to deeper lung regions when compared to a purely axial fluid-particle jet. For example, an optimal helical stream featuring a volumetric flow rate of 30 L/min, increased the delivery of 300-nm particles to regions beyond generation 3 by 5%, in comparison to a conventional axial jet. Results from regional deposition studies are presented to demonstrate the robustness of helical flows in pulmonary drug delivery, thus paving the way toward successful implementation of the novel methodology in nanotherapeutics.Improving diet and physical activity (PA) can reduce the risk of developing type 2 diabetes (T2D); however, long-term diet and PA adherence is poor. To impact population-level T2D risk, scalable interventions facilitating behavior change adherence are needed. Text messaging interventions supplementing behavior change interventions can positively influence health behaviors including diet and PA. The Behavior Change Wheel (BCW) provides structure to intervention design and has been used extensively in health behavior change interventions. Describe the development process of a bank of text messages targeting dietary and PA adherence following a diabetes prevention program using the BCW. The BCW was used to select the target behavior, barriers and facilitators to engaging in the behavior, and associated behavior change techniques (BCTs). Messages were written to map onto BCTs and were subsequently coded for BCT fidelity. The target behaviors were adherence to diet and PA recommendations. A total of 16 barriers/facilitators and 28 BCTs were selected for inclusion in the messages. One hundred and twenty-four messages were written based on selected BCTs. Following the fidelity check a total of 43 unique BCTs were present in the final bank of messages. This study demonstrates the application of the BCW to guide the development of a bank of text messages for individuals with prediabetes. Results underscore the potential utility of having independent coders for an unbiased expert evaluation of what active components are in use. Future research is needed to demonstrate the feasibility and effectiveness of resulting bank of messages.In recent years, the use of methods to investigate muscle-tendon unit function that combine motion capture with ultrasound (MoCapUS) has increased. Although several limitations and individual errors of these methods have been reported, the total error from all the potential sources together has not been estimated. The aim of this study was to establish the total error in the Achilles tendon (AT) measurements, specifically its length (ATL), strain (ATS), and moment arm (ATMA) acquired with MoCapUS during running. The total error from digitizing, marker movement, ultrasound calibration, and probe rotation errors caused mean ATL error of 4.2 ± 0.6 mm, mean ATMA error of 0.1 ± 0.1 mm, and could potentially alter measured ATS by a mean 2.9 ± 0.2%. Correcting both the calcaneus insertion position (CIP) and properly synchronizing ultrasound and motion capture data caused changes of up to 5.4 ± 1.7 mm in ATL and 11.6 ± 1.3 mm in ATMA. CIP correction and synchronization caused a similar amount of change in ATL, as well as ATS. However, the ATMA change was almost exclusively due to the CIP correction. Finally, if all sources of error were combined, the total ATL error could reach 13.1 mm, the total ATMA error could reach 14.4 mm, and ATS differences could reach up to  ± 6.7%. The magnitude of such errors emphasizes the fact that MoCapUS-based AT measurements must be interpreted within the scope of their corresponding errors.
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