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Polydopamine-Coated Poly(l-lactide) Nanofibers with Managed Release of VEGF and BMP-2 as a Restorative Periosteum.
Linear regression analysis revealed that total self-reported physical activity [β = -0.100 (95%CI -0.180 to -0.019)] and leisure-time exercise [β = -0.311 (95%CI -0.468 to -0.155)] were negatively associated with depressive symptoms, but only leisure-time exercise remained significant after adjustment for confounding factors [β = -0.243 (95%CI -0.409 to -0.076)]. Thus, leisure-time exercise was cross-sectionally associated with lower depressive symptoms in community-dwelling adults.HighlightsLeisure-time physical activity was the only physical activity domain associated with lower depressive symptoms.This association appears to be independent of potential confounders.Potential interventions should focus on leisure-time domain.We explored the association between cognitive reserve (CR) and Parkinson' s disease (PD) related cognitive deterioration.Forty PD patients and 12 matched healthy controls (HC) were enrolled. The PD group was balanced for the presence/absence of cognitive impairment. All participants underwent MOCA. CR was measured by the Brief Intelligence Test, and a new comprehensive tool, named Cognitive Reserve Test (CoRe-T), including sections on leisure activities and creativity.Participants with higher CR obtained a better MOCA score irrespective of the group they belonged to. Ertugliflozin At the same time, irrespective of the CR level, the performance of the HC group was always better in comparison to the PD group. Within the PD group, a higher frequency of leisure activities was associated to be cognitively unimpaired, independently by the severity of motor symptoms and age.CR could help to cope with PD-related cognitive decline. Its multidimensional nature could have important applications in prevention and rehabilitation interventions.The current study examined the effects of an 11-week exercise intervention on brain activity during a working memory (WM) task and resting-state functional network connectivity in deaf children. Twenty-six deaf children were randomly assigned to either an 11-week exercise intervention or control conditions. Before and after the exercise intervention, all participants were scanned with functional magnetic resonance imaging (fMRI) during N-back task performance and a resting state. The behavioural results showed that the exercise intervention improved WM performance. Task activation analyses showed an increase in the parietal, occipital, and temporal gyri and hippocampus and hippocampus (HIP). In addition, WM performance improvements were associated with greater activation in the left HIP region. Resting-state functional connectivity (Rs-FC) between HIP and certain other brain areas shown a significant interaction of group (exercise versus no exercise) and time (pre- and postintervention). Moreover, connectivity between the left HIP and left middle frontal gyrus was related to improved WM performance. These data extend current knowledge by indicating that an exercise intervention can improve WM in deaf children, and these enhancements may be related to the WM network plasticity changes induced by exercise.Background/Objectives To develop and evaluate a post-acute care simulation-based mastery learning (SBML) continuing medical education (CME)/maintenance of certification (MOC) procedure course.Design Pretest-posttest study of the SBML intervention.Setting A 2-day post-acute care procedures course.Participants Sixteen practicing clinicians (5 physicians,11 advanced practice providers). Participants engaged in a skills pretest on knee aspiration/injection, gastrostomy tube removal/replacement, tracheostomy tube exchange, and basic suturing using a checklist created for each procedure. Participants received a didactic on each procedure followed by deliberate practice with feedback. Using the same checklists, participants completed a skills posttest and were required to meet a minimum passing standard (MPS) to obtain CME/MOC credit.Measurements The MPS for each skills checklist was determined by a multidisciplinary panel of 11 experts. Participants completed surveys on procedure self-confidence and a course evaluation.Results There was statistically significant improvement between pre- and posttests for all four procedures (p less then .001). All participants were able to meet or exceed the MPS for each skill during the 2-day course. Participants' self-confidence regarding each procedure improved significantly (p less then .001).Conclusion An SBML training course granting CME/MOC credit for post-acute care providers significantly improves performance of knee aspiration/injection, gastrostomy tube removal/replacement, tracheostomy tube exchange, and basic suturing.Rationale Critical care clinicians have high burnout rates. Previous studies have explored individual and organizational solutions to address burnout, but existing literature has not considered how professional societies can prevent burnout and promote member well-being. Objectives The Critical Care Society Collaborative convened a task force to document professional society initiatives to address burnout, explore perspectives on the role of societies to address burnout, and develop recommendations that could guide critical care societies' efforts to promote well-being. Methods We conducted a multiphase evaluation of 17 major U.S. professional societies whose members regularly work in critical care settings. We asked representatives from each society to document their existing well-being initiatives, and we conducted semistructured interviews to explore perspectives on the role of professional societies to address burnout. The task force members then met to discuss phase one and two findings to develop recommendations that could act as a roadmap to guide future society efforts. Results All society representatives agreed that professional societies have a responsibility to address burnout, and they described various well-being initiatives that could act as examples for future efforts. We developed a roadmap with the following recommendations 1) Acknowledge the problem of burnout; 2) Commit to supporting member well-being; 3) Create collaborations to promote well-being; 4) Educate and advocate for change; 5) Foster innovation through research; and 6) Support organizational and individual solutions. Conclusions Our findings highlight a clear role for professional societies to address burnout and promote members' well-being.
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