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Huatan Dingji Decoction intervening within atrial fibrillation: process for the randomized double-blind single-simulated placebo-controlled medical trial.
In general, these models consider the forces that act on the system (both internally generated, or externally imposed) and the mechanical properties of the cell that resist these forces. Moving forward, making these techniques more accessible to the non-expert will help improve interdisciplinary research thereby providing new insight into important biological processes that affect human health. This article is categorized under Cancer > Cancer>Computational Models Cancer > Cancer>Molecular and Cellular Physiology.This review aims to compare the stability of sagittal skeletal and overjet anteroposterior correction of skeletal class III malocclusion in single-jaw and two-jaw orthognathic procedures. An unrestricted comprehensive electronic search was undertaken on Embase, Cochrane's CENTRAL, Web of Science, Medline, Scopus and LILACs databases up to October 2020. The bibliographies of relevant studies, ongoing, unpublished and grey literature were screened. Two independent reviewers performed study selection, bias assessment and data extraction; a third reviewer mediated inconsistencies. Randomized clinical trials, prospective cohort, retrospective cohort and series with a minimum of 1 year follow-up were eligible for inclusion. Additional subgroup analyses were undertaken. The generated effects were scored using the GRADE approach. Nine articles met the inclusion criteria and eight studies were subsequently analysed quantitatively. No significant difference in sagittal stability at the ANB angle, A-point or B-point on a short-term was detected. However, a statistically significant difference, indicating a greater short-term relapse in overjet with mandibular setbacks alone, was found (MD -0.40 mm; 95% CI -0.77 to -0.04; I2 0%; P = .03). Long-term follow-up (≥5 years) revealed a statistically non-significant difference in stability of sagittal skeletal and overjet corrections. Within the limitations of this review, both procedures seem to offer comparable skeletal and overjet stability outcomes; however, further high-quality research is required to confirm these findings.
People with intellectual disabilities are reported to have low self-esteem and to experience high rates of adverse interpersonal experiences (AIEs). This study aimed to investigate whether shame and self-compassion mediate the relationship between AIEs and self-esteem for people with intellectual disabilities and whether perceived social support moderates this relationship.

This study employed a cross-sectional design, involving between-group comparisons. Forty-seven people with intellectual disabilities and 50 people without intellectual disabilities completed self-report questionnaires measuring shame, self-compassion, self-esteem, early AIEs and social support.

Shame and self-compassion were found to mediate the relationship between AIEs and self-esteem for people with intellectual disabilities. There was no evidence for a moderating effect of social support and no difference between groups in shame or self-compassion.

The findings suggest shame and self-compassion are important concepts for people with intellectual disabilities. Clinical and research implications are discussed.
The findings suggest shame and self-compassion are important concepts for people with intellectual disabilities. Clinical and research implications are discussed.Acute appendicitis during pregnancy may lead to increased maternal and fetal risks. Laparoscopic appendectomy is commonly performed during pregnancy. Compared with open appendectomy in pregnant women, laparoscopic appendectomy has shown non-inferior safety for pregnancy outcomes and superior safety for surgical outcomes. Over the last few decades, the occurrence of twin pregnancy has been increasing. Performing an operation on a patient with a twin pregnancy is more difficult than with a singleton pregnancy. Only a few operations of this kind have been reported. Here, we present a case of a 20-week twin pregnant woman who presented with acute appendicitis. Laparoscopic appendectomy was performed, and no maternal complications occurred. This report contributes to discussions on the safety of the laparoscopic approach for appendicitis during twin pregnancies.Excessive absorption of migrating substances from food contact materials can affect human health. Thus, it is essential to analyze the migration of contaminant from food contact materials. However, comprehensive analysis has been challenged by low concentration of migrating substances, manifold and complex matrix interference of food contact materials. Therefore, appropriate sample pretreatment methods should be applied before instrumental detection, which is essential to improve the analytical efficiency, sensitivity, and reliability. This paper systematically reviews the development of sample pretreatment methods for analysis of migrating substances from food contact materials in the past decade. To extract volatile and semi-volatile substances, headspace extraction, headspace solid phase microextraction, and purge and trap technique are discussed. For non-volatile substances, solid-liquid extraction and field-assisted extraction are usually used to extract them from food contact materials, while liquid-liquid extraction, solid phase extraction, and their corresponding microextraction techniques play important roles on enrichment process. In addition, new progress in developments of sample pretreatment methods of food contact materials is summarized, covering new devices, specific adsorbents, and sample preparation methods for rapid detection. An outlook of future prospect of sample pretreatment, especially for non-targeted analysis of non-intentionally added substances is briefly discussed.
This study aimed to assess the correlation between regular statin therapy and postoperative mortality following surgical resection for rectal cancer.

This retrospective cohort study included all adult patients undergoing abdominal rectal cancer surgery in Sweden between January 2007 and September 2016. Data were gathered from the Swedish Colorectal Cancer Registry, a large population-based prospectively collected registry. Statin users were defined as patients with one or more collected prescriptions of a statin within 12months before the date of surgery. The statin-positive and statin-negative cohorts were matched by propensity scores based on baseline demographics.

A total of 11966 patients underwent surgical resection for rectal cancer, of whom 3019 (25%) were identified as statin users. After applying propensity score matching (11), 3017 pairs were available for comparison. In the matched groups, statin users demonstrated reduced 90-day all-cause mortality (0.7% vs. GSK2606414 research buy 5.5%, p<0.001) and also showed significantly reduced cause-specific mortality due to cardiovascular and respiratory events, as well as sepsis and multiorgan failure.
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