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Repairing peripheral nerve injury, especially long-range defects of thick nerves, is a great challenge in the clinic due to their limited regeneration capability. LM-1149 Most FDA-approved nerve guidance conduits with large hollow lumen are only suitable for short lesions, and their effects are unsatisfactory in repairing long gaps of thick nerves. Multichannel nerve guidance conduits have been shown to offer better regeneration of long nerve defects. However, existing approaches of fabricating multichannel nerve conduits are usually complicated and time-consuming. Inspired by the intelligent responsive shaping process of shape memory polymers, in this study, a self-forming multichannel nerve guidance conduit with topographical cues was constructed based on a degradable shape memory PLATMC polymer. With an initial tubular shape obtained by a high-temperature molding process, the electrospun shape memory nanofibrous mat could be temporarily formed into a planar shape for cell loading to realize the uniform distribution of cells. Then triggered by a physical temperature around 37 °C, it could automatically restore its permanent tubular shape to form the multichannel conduit. This multichannel conduit exhibits better performance in terms of cell growth and the repair of rat sciatic nerve defects. These results reveal that self-forming nerve conduits can be realized based on shape memory polymers; thus, the fabricated bioinspired multichannel nerve guidance conduit has great potential in peripheral nerve regeneration.Although ferroptosis therapy has been proven to be a promising strategy for cancer treatment, its efficacy still might be limited by insufficient H2O2 supply in tumor tissue. Herein, we designed a cancer cell membrane-cloaked cascade nanoreactor based on ferric metal-organic frameworks (MOF) and glucose oxidase (GOx) decoration for synergistic ferroptosis-starvation anticancer therapy. The GOx can catalyze glucose to generate sufficient H2O2 for ferroptosis therapy, and the glucose consumption caused by GOx can be utilized as another attractive cancer treatment strategy called starvation therapy. When the nanoreactor reached tumor sites, high concentration of GSH reduced Fe3+ to trigger structure collapse of MOF and release Fe2+ and GOx catalyzed the oxidation of glucose to generate H2O2. Then Fenton reaction happened between H2O2 and Fe2+ to produce hydroxyl radicals (•OH) and promoted ferroptosis therapy. With these cascade reactions, the synergistic ferroptosis-starvation anticancer therapy was realized. Furthermore, the cancer cell membrane endows the nanoreactor homologous targeting and immune escaping ability, which facilitated the nanoreactor to accumulate into tumor site with high efficiency. The nanoreactor exhibits high efficiency for tumor suppression with the in situ consumed and produced compounds, which can promote the development of precise cooperative cancer therapy with spatiotemporal controllability.Replacing organic porous separators with an inorganic solid-state electrolyte (SSE) is a promising strategy to suppress lithium dendrite and inhibit polysulfide dissolution in lithium-sulfur (Li-S) batteries. However, the realization of such a concept is still limited by the large interfacial resistance between SSE and lithium anode. Herein, a new electrolyte additive, copper fluoride (CuF2), is used in liquid electrolytes to construct a stable interphase between Li1.5Al0.5Ge1.5(PO4)3 (LAGP) SSE and Li metal for a quasi-solid-state Li-S battery. A Li||Li symmetric cell with ultralong life over 1500 h (at 0.1 mA cm-2) proves the excellent stability of the as-formed interphase. As a result, the assembled Li-S full cell presents high coulombic efficiency and stable cycling (750 mA h g-1 after 50 cycles) at room temperature with lean liquid electrolytes. This strategy provides an effective method for improving the electrochemical performance of Li-S batteries.A novel UV-Vis photodetector consisting of an octahedral molybdenum cluster-functionalized Zn2Al layered double hydroxide (LDH) has been successfully synthesized by co-precipitation and delamination methods under ambient conditions. The electrophoretic deposition process has been used as a low-cost, fast, and effective method to fabricate thin and transparent nanocomposite films containing a dense and regular layered structure. The study provided evidence that the presence of the Mo6 cluster units between the LDH does not affect the ionic conduction mechanism of the LDH, which linearly depends on the relative humidity and temperature. Moreover, the photocurrent response is remarkably extended to the visible domain. The reproducibility and stabilization of the photocurrent response caused by the Mo6 cluster-functionalized LDH have been verified upon light excitation at 540 nm. Additionally, it was demonstrated that the films show advantageously strong adherence properties for application requirements.Cell-penetrating peptides (CPPs) are capable of delivering membrane-impermeable cargoes (including small molecules, peptides, proteins, nucleic acids, and nanoparticles) into the cytosol of mammalian cells and have the potential to revolutionize biomedical research and drug discovery. However, the mechanism of action of CPPs has remained poorly understood, especially how they escape from the endosome into the cytosol following endocytic uptake. We show herein that CPPs exit the endosome by inducing budding and collapse of CPP-enriched vesicles from the endosomal membrane. This mechanism provides a theoretical basis for designing CPPs and other delivery vehicles of improved efficiencies.ConspectusChromophore aggregates are capable of a wide variety of excited-state dynamics that are potentially of great use in optoelectronic devices based on organic molecules. For example, singlet fission, the process by which a singlet exciton is down converted into two triplet excitons, holds promise for extending the efficiency of solar cells, while other processes, such as excimer formation, are commonly regarded as parasitic pathways or traps. Other processes, such as symmetry-breaking charge transfer, where the excited dimer charge separates into a radical ion pair, can be both a trap and potentially useful in devices, depending on the context. Thus, an understanding of the precise mechanisms of each of these processes is vital to designing tailor-made organic chromophores for molecular optoelectronics.These excited-state phenomena have each been well-studied in recent years and show tantalizing connections as the molecular systems and environments are subtly changed. These seemingly disparate phenomena can be described within the same unifying framework, where each case can be represented as one point in continuum of mixed states.
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