Notes

Contrasting responses to water-deficit amongst Encelia canescens communities dispersed coupled a great aridity incline.
During a pandemic, narrowing ethics into silos such as clinical and public health does not help the cause of ethics, which often gets neglected in desperate times. Our response to a recently published article in this journal, tries to take this discussion forward. Keeping medical ethics at the centre of our response to the Covid-19 pandemic would benefit healthcare systems at all levels. this website This would also help us be prepared for future pandemics. Strengthening healthcare systems would also provide an opportunity to improve non-Covid care..In India, the Covid-19 pandemic has thrown open challenges on multiple fronts (a) the reconfiguration of care in hospitals, in response to Covid-19, has led to many patients suffering non-Covid conditions having to delay their treatment, and (b) the lockdown which though necessary has affected people unequally, some being much worse-off than others. This article unpacks the impact of Covid-19 on healthcare systems in India by raising moral and ethical questions about the plight of patients with other medical conditions while accessing care. This article also proposes a set of actions by which healthcare systems can address Covid and non-Covid related healthcare needs..In 2018, the Division of Health and Humanities at St John's Research Institute introduced the "Citizen Doctor" course for first year medical students at St. John's Medical College. The focus was to expose future doctors to the wider framework of health and invoke a sense of citizenship, responsiveness, and critical thinking. Classes in Environmental sciences and the Constitution of India, advocated as beneficial for all undergraduate students in India, were used as the basis to design the Citizen Doctor Course. This paper is an evaluation of this innovative course. A structured feedback questionnaire was administered to students at the end of the course; an overwhelming majority found that these classes helped them identify and understand contemporary social and environmental issues. It evoked a sense of wider responsibility and responsiveness, thus laying the foundation for a "citizen doctor". The evidence suggests that this course should continue and expand to other years and other medical colleges Keywords citizen, humanities, environmental science, constitution of India, social determinants of health, medical education.Background The COVID-19 epidemic has affected every area of life. The greatest challenge has been to adapt the functioning of the health service to prevent the spread of the epidemic and to help infected patients. This has required the involvement of not only doctors and nurses, but also pharmacists. In the face of this pandemic, governments in many countries have granted pharmacists greater authority. Objectives The purpose of this paper is to review the legal extension of the role of pharmacists in light of the COVID-19 pandemic. The review considers recent changes in European countries, Canada, and the United States. Methods A literature review was performed to summarise knowledge about the extension of the role of pharmacists during the pandemic period. Key articles were retrieved mainly from PubMed and Google Scholar, using the terms "COVID-19", "2019-nCoV", "coronavirus", and "pandemic" in combination with "pharmacist" as keywords for our search. We included scientific publications from February 1, 2019ding the limited resources of overloaded healthcare systems.Municipal solid waste generation is becoming a prominent issue in the environmental arena. The aim of this paper is to investigate the relationship among municipal waste generation, greenhouse gas emissions, and GDP in Switzerland over the period 1990-2017. We apply both time series procedures (stationarity and causality tests) and a Machine Learning approach. Empirical findings underline a bidirectional causal relationship between municipal solid waste generation and GDP, indicating that the Environmental Kuznets Curve hypothesis holds for Switzerland. Moreover, we found that waste recovery (recycling and composting) is a key driver in mitigating greenhouse gas emissions. In fact, in the Tree Model, the probability that a change in the waste recovery variable could lead to a reduction in the greenhouse gas emissions registered a value of 87%.Since the beginning of the COVID-19 pandemic, researchers have focused on repurposing of existing antibiotics, antivirals and anti-inflammatory drugs to find an effective therapy. Fluoroquinolones are broad spectrum synthetic antimicrobial agents, being chemical derivatives of quinoline, the prodrome of chloroquine. Interestingly, fluoroquinolones may exert antiviral actions against vaccinia virus, papovavirus, CMV, VZV, HSV-1, HSV-2, HCV and HIV. A recent in silico study has shown that the fluoroquinolones, ciprofloxacin and moxifloxacin, may inhibit SARS-CoV-2 replication by exhibiting stronger capacity for binding to its main protease than chloroquine and nelfinavir, a protease inhibitor antiretroviral drug. Remarkably, fluoroquinolones have shown multiple immunomodulatory actions leading to an attenuation of the inflammatory response through the inhibition of pro-inflammatory cytokines. Noteworthy, respiratory fluoroquinolones, levofloxacin and moxifloxacin, constitute fist line therapeutic agents for the management of severe community-acquired pneumonia. They are characterized by advantageous pharmacokinetic properties; higher concentrations in the lungs; and an excellent safety profile comparable to other antibiotics used to treat respiratory infections, such as macrolides and b-lactams. Based on their potential antiviral activity and immunomodulatory properties, the favorable pharmacokinetics and safety profile, we propose the use of respiratory fluoroquinolones as adjuncts in the treatment of SARS-CoV-2 associated pneumonia.Background Cervical Cancer (CC) is a worldwide public health concern associated with genetic alterations, among these the gain of the 19q chromosome harboring the Pregnancy Specific Glycoproteins (PSG) gene family. These proteins play a critical role in pregnancy, with participation in immunotolerance, angiogenesis, and invasion processes, which are also observed in carcinogenesis. The aim of this study was to determine the molecular alterations of PSG1 and its relationship with CC. Methods PSG1 Copy Number Variation (CNV) was evaluated in 31 CC and eight normal cervical tissues by qPCR. PSG1 expression was correlated with HPV detection and IL-10 and TGF-β expression in CC samples. Finally, PSG1 protein expression was evaluated by immunofluorescence in CC cell lines, by immunohistochemistry in a tissue microarray, and by immunoblotting in the sera of women with normal cervix, pre-invasive lesions, and CC. Results PSG1 showed a gain of 25.6% in CNV and gene expression in CC. There was a lack of PSG1 expression in normal cervical epithelium and positive immunostaining in 57% of CC tissues, while all CC cell lines expressed PSG1.
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