Notes

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Morvan's syndrome (MoS) is a rare autoimmune disorder characterized by central nervous system involvement, autonomic dysfunction and peripheral nerve hyperexcitability. MoS is believed to be caused by autoantibodies targeting contactin-associated protein 2 (Caspr2), a subunit of the neuronal voltage-gated potassium channel (VGKC) complex, usually in association with thymoma, less commonly with other malignancies. This case highlights an exceptional case of severe sleep disturbances and behavioural changes due to MoS, in a patient who would present with and be treated successfully for a second relapse of thymoma 30 months later. Originally he suffered from ocular myasthenia, another autoimmune disorder, which led to diagnosis of his original thymoma and first relapse.Staphylococcus pettenkoferi (S.pettenkoferi), originally described in Germany in 2002 by Trülzsch et al, is a coagulase negative staphylococcus whose clinical relevance is yet to be determined. With about 10 case reports in the literature from several parts of the world, there is no data on S. WH-4-023 in vitro pettenkoferi infection from the United States. This is a retrospective cohort study of 80 patients ≥ 18 years of age who had at least 1 S. pettenkoferi-positive blood culture, identified by matrix-assisted laser desorption/ionization time-of-flight at a tertiary academic center in Detroit, Michigan. We describe the features of S. pettenkoferi-positive blood cultures in order to identify cases of true bacteremia. The mean age of the cohort was 66 ± 16 years and 1 out of 3 had immunosuppressing conditions. No case of true S.pettenkoferi bacteremia was identified. More studies are needed to determine its role as a pathogen in the United States.The treatment of municipal wastewater is an energy-intensive process, with the delivery of oxygen as an electron acceptor accounting for a significant share of the total energy consumption. Microbial communities growing on polarized electrodes can facilitate wastewater treatment processes by exchanging electrons with the electrodes. As a new approach, we combined the use of polarized electrodes with microbial fuel cells (MFCs) to develop a switchable dual-mode bioelectrochemical wastewater treatment system. In this system, we first enriched microbial communities on polarized anodes and cathodes. After enrichment, the system was switched to either a self-powered MFC (SP-MFC) mode or a potentiostatically controlled (PC) mode. The system was evaluated at the laboratory scale (260 L, 4 anode and cathode pairs) and the pilot scale (1200 L, 16 anode and cathode pairs). PC and SP-MFC systems showed improved COD removal relative to control (41.6 ± 3.5 and 38.4 ± 3.1 vs 28.8 ± 2.1 mg L-1 d-1, respectively). The laboratory-scale system was operated without biological or electrical interruption for one year. Finally, specific enrichment of active microbial communities was observed on PC anodes in comparison to mixed-operation and non-polarized control anodes. The combined PC and SP-MFC systems allowed us to develop a sustainable and failure-free bioelectrochemical wastewater treatment system.
The High Mobility Group Box 1 (HMGB1) is a nuclear protein that is frequently overexpressed in hematologic diseases and might be of relevance in immunogenic cancer control thus correlating with patients' (pts.) prognosis in diseases such as acute myeloid, acute lymphatic and chronic lymphocytic leukemia.

Expression profiles of blasts from AML (n=21), ALL (n=16) and of B-lymphocytes of CLL (n=9) pts. were analyzed for surface expression of HMGB1 using flow cytometry. Expression was quantified and correlated with clinically and prognostically relevant markers.

Expression profiling of HMGB1 in blasts of AML and ALL subtypes did not show differences between primary vs. secondary disease development and gender related differences. In ALL pts. however, age groups at initial diagnosis between ≥20 vs. <20years were compared and showed significant differences (≥20 vs. <20years; 89% vs. 49%, p<0.05) with higher expression in higher age. In AML and CLL these differences were not visible. To evaluate the pt and treatment planning.
HMGB1 is frequently expressed in hematologic malignancies. In this study it was shown that HMGB1 surface expression on AML blasts can be used as predictors for treatment response. In CLL it may be a marker for advanced disease. In order to implement this marker in FACS routine it could be a useful and practical tool for prognostic assessment and treatment planning.The purpose of this work was to study the biodegradation of crude oil under alkaline condition by defined co-culture of Acinetobacter baumannii and Talaromyces sp. The n-alkanes in crude oil could be completely degraded by bacteria and fungi with the ratio of 11 at pH 9 in 14 d water simulation experiment. Meanwhile, the total degradation rate of crude oil could reach 80%. Fungi had stronger ability to degrade n-alkanes, while bacteria could better degrade other components such as aromatics and branched alkanes. The two strains were both capable of producing a small amount of biosurfactant. High cell viability was the main factor for strains to exert high degradation ability in alkaline environment. It was preliminarily verified that bacteria and fungi rely on the differences of enzyme systems to achieve synergy in the degradation process. These results indicated that the defined co-culture had great potential for bioremediation in alkaline soils.The coexistence of F-, Ca2+, nitrates, and other pollutants in water body has aroused widespread concern. In this research, a novel quartz sand biofilm reactor was established, aiming to study the key factors of different carbon to nitrogen (C/N) ratios (51, 41, and 31), initial Ca2+ concentration (180 mg L-1, 144 mg L-1, and 108 mg L-1), and hydraulic retention time (HRT) (4 h, 6 h, and 8 h) on simultaneous Ca2+ precipitation, F- removal, and denitrification. Results showed that the removal efficiencies of Ca2+, F-, and nitrate were 55.04%, 82.64%, and 97.69% under the low C/N ratio of 31, initial Ca2+ concentration of 180 mg L-1, and HRT of 8 h. 3-D Excitation-Emission Fluorescence Spectroscopy (3-D EEM) demonstrates that extracellular polymeric substances (EPS) was generated during the growth metabolism. Scanning Electron Microscopy (SEM) and X-ray diffractometer images showed that Ca2+, F- removed in the form of CaCO3, Ca5(PO4)3F and CaF2 under Acinetobacter sp. H12 induction. Moreover, high-throughput sequencing results display that the biomineralized bacteria Acinetobacter sp.
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